Protein detail
PPE1
Serine/threonine-protein phosphatase with EF-hands 1 (PPEF-1) (EC 3.1.3.16) (Protein phosphatase with EF calcium-binding domain) (PPEF) (Serine/threonine-protein phosphatase 7) (PP7)
Entry name PPE1 | UniProt ID | EVMP confidence score 0.38 |
Supporting publications (n) 2 | Transmembrane count | Protein classification |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information6
Protein Names
Serine/threonine-protein phosphatase with EF-hands 1 (PPEF-1) (EC 3.1.3.16) (Protein phosphatase with EF calcium-binding domain) (PPEF) (Serine/threonine-protein phosphatase 7) (PP7)
Protein Function (3)
- Enzymes
- Predicted intracellular proteins
- ENZYME proteins:Hydrolases
Ensembl
Entrez Gene Symbol
Supporting publications (n)
2
EVMP confidence score
0.38
Fluorescence & Localization5
Tissue Specificchoroid plexusBrain Regional Specificchoroid plexusCell SpecificAdrenal cortex cellsBlood Cell Specificnaive CD4 T-cellBlood Lineage SpecificT-cells
Function & Pathway7
Protein Function (3)
- Enzymes
- Predicted intracellular proteins
- ENZYME proteins:Hydrolases
Cellular Component (2)
Molecular Function (6)
Biological Process (3)
Reactome (3)
Canonical Pathways (2)
- M37 Pid nfkappab canonical pathway
- M110 Pid il1 pathway
Mediation Categories
Metabolism mediation
Relations & Evidence5
Ligand-Receptor Signaling (3)
3 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Regulatory Interaction Network (1)
1 record.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| PPE1 | O14829 | PDCD5 | O14737 | Yes | No | Yes | SIGNOR | SIGNOR:28051100 |
Sequence, Structure & Domains9
Sequences
Length
653
Mass
75,792
Sequence
MGCSSSSTKTRRSDTSLRAALIIQNWYRGYKARLKARQHYALTIFQSIEYADEQGQMQLSTFFSFMLENYTHIHKEELELRNQSLESEQDMRDRWDYVDSIDVPDSYNGPRLQFPLTCTDIDLLLEAFKEQQILHAHYVLEVLFETKKVLKQMPNFTHIQTSPSKEVTICGDLHGKLDDLFLIFYKNGLPSERNPYVFNGDFVDRGKNSIEILMILCVSFLVYPNDLHLNRGNHEDFMMNLRYGFTKEILHKYKLHGKRILQILEEFYAWLPIGTIVDNEILVIHGGISETTDLNLLHRVERNKMKSVLIPPTETNRDHDTDSKHNKVGVTFNAHGRIKTNGSPTEHLTEHEWEQIIDILWSDPRGKNGCFPNTCRGGGCYFGPDVTSKILNKYQLKMLIRSHECKPEGYEICHDGKVVTIFSASNYYEEGSNRGAYIKLCSGTTPRFFQYQVTKATCFQPLRQRVDTMENSAIKILRERVISRKSDLTRAFQLQDHRKSGKLSVSQWAFCMENILGLNLPWRSLSSNLVNIDQNGNVEYMSSFQNIRIEKPVQEAHSTLVETLYRYRSDLEIIFNAIDTDHSGLISVEEFRAMWKLFSSHYNVHIDDSQVNKLANIMDLNKDGSIDFNEFLKAFYVVHRYEDLMKPDVTNLG
Alternative Products
Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=O14829-1; Sequence=Displayed; Name=1A; IsoId=O14829-2; Sequence=VSP_005098; Name=1B; IsoId=O14829-3; Sequence=VSP_005099; Name=2; IsoId=O14829-4; Sequence=VSP_005100, VSP_005101; Name=3; IsoId=O14829-5; Sequence=VSP_005102
Alternative Sequence
79..132; Missing (in isoform 1A); 328..355; Missing (in isoform 1B); 356..417; Missing (in isoform 3); 356..376; IIDILWSDPRGKNGCFPNTCR -> SGYYGKQRHQDIKRESDFTKK (in isoform 2); 377..653; Missing (in isoform 2)
Domain & Motif Annotations
Domain (FT)
16..45; IQ; 483..518; EF-hand 1; 566..601; EF-hand 2; 606..641; EF-hand 3
Region
121..455; Catalytic
Protein Families
PPP phosphatase family
Sequence Similarities
Belongs to the PPP phosphatase family.
Supporting Publications2
| PMID | Title | Abstract |
|---|---|---|
| 30608700 | Quantitative Proteomic Analysis of Small and Large Extracellular Vesicles (EVs) Reveals Enrichment of Adhesion Proteins in Small EVs. | No abstract available |
| 38731868 | The Deep Proteomics Approach Identified Extracellular Vesicular Proteins Correlated to Extracellular Matrix in Type One and Two Endometrial Cancer. | No abstract available |