Protein detail

PPE1

Serine/threonine-protein phosphatase with EF-hands 1 (PPEF-1) (EC 3.1.3.16) (Protein phosphatase with EF calcium-binding domain) (PPEF) (Serine/threonine-protein phosphatase 7) (PP7)

Entry name
PPE1
UniProt ID
O14829
EVMP confidence score
0.40
Supporting publications (n)
2
Transmembrane count
Protein classification
Basic Information
Protein Names
Serine/threonine-protein phosphatase with EF-hands 1 (PPEF-1) (EC 3.1.3.16) (Protein phosphatase with EF calcium-binding domain) (PPEF) (Serine/threonine-protein phosphatase 7) (PP7)
Protein Function (3)
  • Enzymes
  • Predicted intracellular proteins
  • ENZYME proteins:Hydrolases
Ensembl
ENSG00000086717
Entrez Gene Symbol
PPEF1
Supporting publications (n)
2
EVMP confidence score
0.40
Fluorescence & Localization
Tissue Specificchoroid plexusBrain Regional Specificchoroid plexusCell SpecificAdrenal cortex cellsBlood Cell Specificnaive CD4 T-cellBlood Lineage SpecificT-cells
Function & Pathway
Protein Function (3)
  • Enzymes
  • Predicted intracellular proteins
  • ENZYME proteins:Hydrolases
Cellular Component (2)
Molecular Function (6)
Biological Process (3)
Reactome (3)
Canonical Pathways (2)
  • M37 Pid nfkappab canonical pathway
  • M110 Pid il1 pathway
Mediation Categories
Metabolism mediation
Relations & Evidence5

Ligand-Receptor Signaling (3)

3 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
intracellularintracellularComPPI
intracellularintracellularGO_Intercell
intracellularintracellularOmniPath

Regulatory Interaction Network (1)

1 record.

Source Protein SymbolSource UniProt IDTarget Protein SymbolTarget UniProt IDIs DirectedIs StimulationIs InhibitionDatabaseReferences
PPE1O14829PDCD5O14737YesYesSIGNORSIGNOR:28051100

Isolation & Detection Technology (1)

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Differential UltracentrifugationDensity Gradient CentrifugationSize Exclusion ChromatographyImmunoaffinity CaptureAntibody array3245051144009834631588238
Sequence, Structure & Domains

Sequences

Length
653
Mass
75,792
Sequence
MGCSSSSTKTRRSDTSLRAALIIQNWYRGYKARLKARQHYALTIFQSIEYADEQGQMQLSTFFSFMLENYTHIHKEELELRNQSLESEQDMRDRWDYVDSIDVPDSYNGPRLQFPLTCTDIDLLLEAFKEQQILHAHYVLEVLFETKKVLKQMPNFTHIQTSPSKEVTICGDLHGKLDDLFLIFYKNGLPSERNPYVFNGDFVDRGKNSIEILMILCVSFLVYPNDLHLNRGNHEDFMMNLRYGFTKEILHKYKLHGKRILQILEEFYAWLPIGTIVDNEILVIHGGISETTDLNLLHRVERNKMKSVLIPPTETNRDHDTDSKHNKVGVTFNAHGRIKTNGSPTEHLTEHEWEQIIDILWSDPRGKNGCFPNTCRGGGCYFGPDVTSKILNKYQLKMLIRSHECKPEGYEICHDGKVVTIFSASNYYEEGSNRGAYIKLCSGTTPRFFQYQVTKATCFQPLRQRVDTMENSAIKILRERVISRKSDLTRAFQLQDHRKSGKLSVSQWAFCMENILGLNLPWRSLSSNLVNIDQNGNVEYMSSFQNIRIEKPVQEAHSTLVETLYRYRSDLEIIFNAIDTDHSGLISVEEFRAMWKLFSSHYNVHIDDSQVNKLANIMDLNKDGSIDFNEFLKAFYVVHRYEDLMKPDVTNLG
Alternative Products
Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=O14829-1; Sequence=Displayed; Name=1A; IsoId=O14829-2; Sequence=VSP_005098; Name=1B; IsoId=O14829-3; Sequence=VSP_005099; Name=2; IsoId=O14829-4; Sequence=VSP_005100, VSP_005101; Name=3; IsoId=O14829-5; Sequence=VSP_005102
Alternative Sequence
79..132; Missing (in isoform 1A); 328..355; Missing (in isoform 1B); 356..417; Missing (in isoform 3); 356..376; IIDILWSDPRGKNGCFPNTCR -> SGYYGKQRHQDIKRESDFTKK (in isoform 2); 377..653; Missing (in isoform 2)

Domain & Motif Annotations

Domain (FT)
16..45; IQ; 483..518; EF-hand 1; 566..601; EF-hand 2; 606..641; EF-hand 3
Region
121..455; Catalytic
Protein Families
PPP phosphatase family
Sequence Similarities
Belongs to the PPP phosphatase family.
Supporting Publications2
PMIDTitleRelated sentences
30608700Quantitative Proteomic Analysis of Small and Large Extracellular Vesicles (EVs) Reveals Enrichment of Adhesion Proteins in Small EVs.No related sentences available
38731868The Deep Proteomics Approach Identified Extracellular Vesicular Proteins Correlated to Extracellular Matrix in Type One and Two Endometrial Cancer.No related sentences available