Protein detail
FFAR1
Free fatty acid receptor 1 (G-protein coupled receptor 40)
Entry name FFAR1 | UniProt ID | EVMP confidence score 0.53 |
Supporting publications (n) 2 | Transmembrane count 7 | Protein classification |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Free fatty acid receptor 1 (G-protein coupled receptor 40)
Protein Function (3)
- Transporters
- FDA approved drug targets:Small molecule drugs
- G-protein coupled receptors:GPCRs excl olfactory receptors
Transmembrane
9..31; Helical; Name=1; 42..64; Helical; Name=2; 80..101; Helical; Name=3; 122..142; Helical; Name=4; 179..200; Helical; Name=5; 224..248; Helical; Name=6; 257..279; Helical; Name=7
Transmembrane Count
7
Ensembl
Entrez Gene Symbol
Supporting publications (n)
2
EVMP confidence score
0.53
Fluorescence & Localization
Function & Pathway
Protein Function (3)
- Transporters
- FDA approved drug targets:Small molecule drugs
- G-protein coupled receptors:GPCRs excl olfactory receptors
Cellular Component
Molecular Function (3)
Biological Process (3)
Reactome (13)
- R-hsa-373076 class a 1 rhodopsin like receptors
- R-hsa-434316 fatty acids bound to gpr40 ffar1 regulate insulin secretion
- R-hsa-400451 free fatty acids regulate insulin secretion
- R-hsa-444209 free fatty acid receptors
- R-hsa-500792 gpcr ligand binding
- R-hsa-416476 g alpha q signalling events
- R-hsa-400508 incretin synthesis secretion and inactivation
- R-hsa-163685 integration of energy metabolism
- R-hsa-2980736 peptide hormone metabolism
- R-hsa-422356 regulation of insulin secretion
Page 1 of 2
Mediation Categories (4)
Fusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence48
Ligand-Receptor Signaling (38)
38 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| gpcr | receptor | Surfaceome | Yes | Yes | |||
| class_a_rhodopsin | receptor | GPCRdb | Yes | Yes | |||
| class_a_rhodopsin_lipid | receptor | GPCRdb | Yes | Yes | |||
| class_a_rhodopsin_lipid_free_fatty_acid | receptor | GPCRdb | Yes | Yes | |||
| receptor | receptor | OmniPath | Yes | Yes | |||
| extracellular | extracellular | HPMR | Yes | ||||
| extracellular | extracellular | OmniPath | Yes | ||||
| transmembrane | transmembrane | UniProt_location | Yes | ||||
| transmembrane | transmembrane | UniProt_topology | Yes | ||||
| transmembrane | transmembrane | UniProt_keyword | Yes |
Regulatory Interaction Network (9)
9 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| FFAR1 | O14842 | GNAQ | P50148 | Yes | Yes | HPRDHINTSIGNOR | HINT:12629551HINT:12496284SIGNOR:31160049HPRD:12496284HPRD:12629551 | |
| FFAR1 | O14842 | GNAO | P09471 | Yes | Yes | SIGNOR | SIGNOR:31160049 | |
| FFAR1 | O14842 | GNAL | P38405 | Yes | Yes | SIGNOR | SIGNOR:31160049 | |
| FFAR1 | O14842 | GNAS3 | O95467 | Yes | Yes | SIGNOR | SIGNOR:31160049 | |
| FFAR1 | O14842 | ALEX | P84996 | Yes | Yes | SIGNOR | SIGNOR:31160049 | |
| FFAR1 | O14842 | GNAS2 | P63092 | Yes | Yes | SIGNOR | SIGNOR:31160049 | |
| FFAR1 | O14842 | GNAS1 | Q5JWF2 | Yes | Yes | SIGNOR | SIGNOR:31160049 | |
| FFAR1 | O14842 | GNAI1 | P63096 | Yes | Yes | HPRDSIGNOR | HPRD:12496284HPRD:12629551SIGNOR:31160049 | |
| FFAR1 | O14842 | GNA12 | Q03113 | Yes | Yes | SIGNOR | SIGNOR:31160049 |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Mass spectrometry | 0 |
Sequence, Structure & Domains
Sequences
Length
300
Mass
31,457
Sequence
MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK
3D Structural Models
Turn
68..70
Helix
5..36; 40..67; 76..78; 79..109; 111..117; 121..145; 176..190; 192..211; 214..235; 237..249; 256..266; 268..275
Beta Strand
149..151; 154..157; 169..171
3D Structure
Electron microscopy (5); X-ray crystallography (4)
Domain & Motif Annotations
Protein Families
G-protein coupled receptor 1 family
Sequence Similarities
Belongs to the G-protein coupled receptor 1 family.
Clinical Relevance
Supporting Publications2
| PMID | Title | Related sentences |
|---|---|---|
| 37686366 | Identification of a Non-Invasive Urinary Exosomal Biomarker for Diabetic Nephropathy Using Data-Independent Acquisition Proteomics. | No related sentences available |
| 39290459 | Urinary extracellular vesicles as a monitoring tool for renal damage in patients not meeting criteria for chronic kidney disease. | No related sentences available |