Protein detail

T4S5

Transmembrane 4 L6 family member 5 (Tetraspan transmembrane protein L6H)

Entry name T4S5	UniProt ID O14894	EVMP confidence score 0.50
Supporting publications (n) 1	Transmembrane count 4	Protein classification

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information8

Protein Names

Transmembrane 4 L6 family member 5 (Tetraspan transmembrane protein L6H)

Protein Function

Transporters:Accessory Factors Involved in Transport

Transmembrane

10..30; Helical; 47..67; Helical; 91..111; Helical; 158..178; Helical

Transmembrane Count

Ensembl

ENSG00000142484

Entrez Gene Symbol

TM4SF5

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization5

Tissue SpecificesophagusCell SpecificEsophageal apical cellsSingle-Nuclei Brain Specificdeep-layer intratelencephalicSecretome LocationSecreted in other tissuesSecretome FunctionEnzyme

Function & Pathway5

Protein Function

Transporters:Accessory Factors Involved in Transport

Cellular Component (3)

Molecular Function (2)

Biological Process (3)

Mediation Categories

Fusion and delivery mediation

Relations & Evidence22

Ligand-Receptor Signaling (21)

21 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	HPMR	No	Yes	No	Yes	No
tetraspanins	receptor	HPMR	No	Yes	No	Yes	No
tm4sf5	receptor	HPMR	No	Yes	No	Yes	No
receptor	receptor	OmniPath	No	Yes	No	Yes	No
extracellular	extracellular	HPMR	No	No	No	Yes	No
extracellular	extracellular	OmniPath	No	No	No	Yes	No
intracellular	intracellular	GO_Intercell	No	No	No	Yes	No
intracellular	intracellular	UniProt_location	No	No	No	Yes	No
intracellular	intracellular	OmniPath	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_location	No	No	No	Yes	No

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Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion ChromatographyImmunoaffinity Capture	Western blotting	2	38731868 40098346

Sequence, Structure & Domains6

Sequences

Length

197

Mass

20,823

Sequence

MCTGKCARCVGLSLITLCLVCIVANALLLVPNGETSWTNTNHLSLQVWLMGGFIGGGLMVLCPGIAAVRAGGKGCCGAGCCGNRCRMLRSVFSSAFGVLGAIYCLSVSGAGLRNGPRCLMNGEWGYHFEDTAGAYLLNRTLWDRCEAPPRVVPWNVTLFSLLVAASCLEIVLCGIQLVNATIGVFCGDCRKKQDTPH

Domain & Motif Annotations

Region

91..197; Interaction with MTOR and CASTOR1

Protein Families

L6 tetraspanin family

Sequence Similarities

Belongs to the L6 tetraspanin family.

Supporting Publications1

PMID	Title	Abstract
39408670	Proteomic Characterization of Corneal Epithelial and Stromal Cell-Derived Extracellular Vesicles.	No abstract available