Protein detail

ZN646

Zinc finger protein 646

Entry name ZN646	UniProt ID O15015	EVMP confidence score 0.38
Supporting publications (n) 1	Transmembrane count	Protein classification Predicted intracellular proteinsTranscription factors

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Zinc finger protein 646

Protein Class (2)

Predicted intracellular proteinsTranscription factors

Protein Function (2)

Predicted intracellular proteins
Transcription factors:Zinc-coordinating DNA-binding domains

Ensembl

ENSG00000167395

Entrez Gene Symbol

ZNF646

Gene Synonym

KIAA0296

Gene Description

Zinc finger protein 646

Chromosome

Position

31074422-31084196

Supporting publications (n)

EVMP confidence score

0.38

Function & Pathway5

Protein Function (2)

Predicted intracellular proteins
Transcription factors:Zinc-coordinating DNA-binding domains

Cellular Component

GO:0005634 nucleus

Molecular Function (4)

Biological Process (3)

Mediation Categories

Other mediation

Relations & Evidence8

Ligand-Receptor Signaling (4)

4 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Protein Complex Composition (3)

3 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database
BNC2 CHCHD10 RBM26 TNFRSF13B ZNF579 ZNF646	O14836 O15015 Q5T8P6 Q6ZN30 Q8NAF0 Q8WYQ3	0:0:0:0:0:0	hu.MAP2
FIZ1 TNFRSF13B ZNF579 ZNF646	O14836 O15015 Q8NAF0 Q96SL8	0:0:0:0	hu.MAP2
FIZ1 TNFRSF13B ZFP91 ZNF646	O14836 O15015 Q96JP5 Q96SL8	0:0:0:0	hu.MAP2

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion ChromatographyImmunoaffinity Capture	Western blotting	2	38731868 40098346

Sequence, Structure & Domains10

Sequences

Length

1,832

Mass

200,825

Sequence

MEDTPPSLSCSDCQRHFPSLPELSRHRELLHPSPNQDSEEADSIPRPYRCQQCGRGYRHPGSLVNHRRTHETGLFPCTTCGKDFSNPMALKSHMRTHAPEGRRRHRPPRPKEATPHLQGETVSTDSWGQRLGSSEGWENQTKHTEETPDCESVPDPRAASGTWEDLPTRQREGLASHPGPEDGADGWGPSTNSARAPPLPIPASSLLSNLEQYLAESVVNFTGGQEPTQSPPAEEERRYKCSQCGKTYKHAGSLTNHRQSHTLGIYPCAICFKEFSNLMALKNHSRLHAQYRPYHCPHCPRVFRLPRELLEHQQSHEGERQEPRWEEKGMPTTNGHTDESSQDQLPSAQMLNGSAELSTSGELEDSGLEEYRPFRCGDCGRTYRHAGSLINHRKSHQTGVYPCSLCSKQLFNAAALKNHVRAHHRPRQGVGENGQPSVPPAPLLLAETTHKEEEDPTTTLDHRPYKCSECGRAYRHRGSLVNHRHSHRTGEYQCSLCPRKYPNLMALRNHVRVHCKAARRSADIGAEGAPSHLKVELPPDPVEAEAAPHTDQDHVCKHEEEATDITPAADKTAAHICSICGLLFEDAESLERHGLTHGAGEKENSRTETTMSPPRAFACRDCGKSYRHSGSLINHRQTHQTGDFSCGACAKHFHTMAAMKNHLRRHSRRRSRRHRKRAGGASGGREAKLLAAESWTRELEDNEGLESPQDPSGESPHGAEGNLESDGDCLQAESEGDKCGLERDETHFQGDKESGGTGEGLERKDASLLDNLDIPGEEGGGTHFCDSLTGVDEDQKPATGQPNSSSHSANAVTGWQAGAAHTCSDCGHSFPHATGLLSHRPCHPPGIYQCSLCPKEFDSLPALRSHFQNHRPGEATSAQPFLCCLCGMIFPGRAGYRLHRRQAHSSSGMTEGSEEEGEEEGVAEAAPARSPPLQLSEAELLNQLQREVEALDSAGYGHICGCCGQTYDDLGSLERHHQSQSSGTTADKAPSPLGVAGDAMEMVVDSVLEDIVNSVSGEGGDAKSQEGAGTPLGDSLCIQGGESLLEAQPRPFRCNQCGKTYRHGGSLVNHRKIHQTGDFLCPVCSRCYPNLAAYRNHLRNHPRCKGSEPQVGPIPEAAGSSELQVGPIPEGGSNKPQHMAEEGPGQAEVEKLQEELKVEPLEEVARVKEEVWEETTVKGEEIEPRLETAEKGCQTEASSERPFSCEVCGRSYKHAGSLINHRQSHQTGHFGCQACSKGFSNLMSLKNHRRIHADPRRFRCSECGKAFRLRKQLASHQRVHMERRGGGGTRKATREDRPFRCGQCGRTYRHAGSLLNHRRSHETGQYSCPTCPKTYSNRMALKDHQRLHSENRRRRAGRSRRTAVRCALCGRSFPGRGSLERHLREHEETEREPANGQGGLDGTAASEANLTGSQGLETQLGGAEPVPHLEDGVPRPGERSQSPIRAASSEAPEPLSWGAGKAGGWPVGGGLGNHSGGWVPQFLTRSEEPEDSVHRSPCHAGDCQLNGPTLSHMDSWDNRDNSSQLQPGSHSSCSQCGKTYCQSGSLLNHNTNKTDRHYCLLCSKEFLNPVATKSHSHNHIDAQTFACPDCGKAFESHQELASHLQAHARGHSQVPAQMEEARDPKAGTGEDQVVLPGQGKAQEAPSETPRGPGESVERARGGQAVTSMAAEDKERPFRCTQCGRSYRHAGSLLNHQKAHTTGLYPCSLCPKLLPNLLSLKNHSRTHTDPKRHCCSICGKAFRTAARLEGHGRVHAPREGPFTCPHCPRHFRRRISFVQHQQQHQEEWTVAGSGAPVAPVTGRGDLPLPPPPTPTTPLLDPSPQWPADLSFSL

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=2; IsoId=O15015-2; Sequence=Displayed; Name=1; IsoId=O15015-1; Sequence=VSP_060189

Alternative Sequence

1794..1832; APVAPVTGRGDLPLPPPPTPTTPLLDPSPQWPADLSFSL -> RGHEGSQEEVGTQWRGKSSPKVGGGARSERREPRGF (in isoform 1)

Domain & Motif Annotations

Compositional Bias

94..108; Basic residues; 313..329; Basic and acidic residues; 661..678; Basic residues; 735..767; Basic and acidic residues; 798..810; Polar residues; 912..922; Acidic residues; 1378..1393; Basic and acidic residues; 1406..1417; Polar residues; 1427..1438; Basic and acidic residues; 1460..1475; Gly residues

Zinc Finger

8..31; C2H2-type 1; 48..70; C2H2-type 2; 75..97; C2H2-type 3; 239..261; C2H2-type 4; 266..288; C2H2-type 5; 294..316; C2H2-type 6; 374..396; C2H2-type 7; 401..424; C2H2-type 8; 465..487; C2H2-type 9; 492..514; C2H2-type 10; 575..597; C2H2-type 11; 617..639; C2H2-type 12; 644..666; C2H2-type 13; 821..843; C2H2-type 14; 848..870; C2H2-type 15; 881..904; C2H2-type 16; 958..980; C2H2-type 17; degenerate; 1052..1074; C2H2-type 18; 1079..1101; C2H2-type 19; 1203..1225; C2H2-type 20; 1230..1252; C2H2-type 21; 1258..1280; C2H2-type 22; 1299..1321; C2H2-type 23; 1326..1348; C2H2-type 24; 1364..1386; C2H2-type 25; 1557..1579; C2H2-type 26; 1585..1607; C2H2-type 27; 1677..1699; C2H2-type 28; 1704..1726; C2H2-type 29; 1732..1754; C2H2-type 30; 1761..1783; C2H2-type 31

Region

26..47; Disordered; 94..200; Disordered; 313..346; Disordered; 660..810; Disordered; 901..931; Disordered; 1103..1148; Disordered; 1274..1294; Disordered; 1377..1481; Disordered; 1509..1529; Disordered; 1606..1672; Disordered; 1781..1832; Disordered

Protein Families

Krueppel C2H2-type zinc-finger protein family

Sequence Similarities

Belongs to the krueppel C2H2-type zinc-finger protein family.

Clinical Relevance1

Antibody (2)

HPA042364 HPA066468

Supporting Publications1

PMID	Title	Abstract
40098346	Toward Identification of Markers for Brain-Derived Extracellular Vesicles in Cerebrospinal Fluid: A Large-Scale, Unbiased Analysis Using Proximity Extension Assays.	No abstract available