Protein detail

SPTN2

Spectrin beta chain, non-erythrocytic 2 (Beta-III spectrin) (Spinocerebellar ataxia 5 protein)

Entry name SPTN2	UniProt ID O15020	EVMP confidence score 0.38
Supporting publications (n) 1	Transmembrane count	Protein classification Disease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Spectrin beta chain, non-erythrocytic 2 (Beta-III spectrin) (Spinocerebellar ataxia 5 protein)

Protein Class (4)

Disease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteins

Protein Function (3)

Human disease related genes:Nervous system diseases:Neurodegenerative diseases
Disease related genes
Predicted intracellular proteins

Ensembl

ENSG00000173898

Entrez Gene Symbol

SPTBN2

Gene Synonym

SCA5

Gene Description

Spectrin beta, non-erythrocytic 2

Chromosome

Position

66682497-66744670

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization3

Tissue Specificskeletal muscleCell SpecificAdrenal cortex cellsSingle-Nuclei Brain Specificendothelial cell

Function & Pathway6

Protein Function (3)

Human disease related genes:Nervous system diseases:Neurodegenerative diseases
Disease related genes
Predicted intracellular proteins

Cellular Component (15)

Page 1 of 2

Molecular Function (7)

KEGG (4)

Reactome (15)

Page 1 of 2

Mediation Categories (4)

Fusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation

Relations & Evidence21

Enzyme-Mediated Modification (1)

1 record.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
SPTBN2	EGF	P01133	S	2,171	phosphorylation	BEL-Large-Corpus_ProtMapperProtMapper	ProtMapper:17081983

Ligand-Receptor Signaling (9)

9 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
ecm	ecm	GO_Intercell	Yes	No	No	No	No
ecm	ecm	OmniPath	Yes	No	No	No	No
extracellular	extracellular	OmniPath	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
ligand	ligand	CellTalkDB	Yes	No	No	No	No
ligand	ligand	OmniPath	Yes	No	No	No	No

Protein Complex Composition (10)

10 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
Non-erythrocytic spectrin	SPTAN1 SPTBN2	O15020 Q13813	0:0	SIGNOR	SIGNOR:SIGNOR-C385
	LSM1 LSM2 LSM3 LSM4 LSM5 SPTBN2	O15020 O15116 P62310 Q9Y333 Q9Y4Y9 Q9Y4Z0	0:0:0:0:0:0	hu.MAP
	LSM4 LSM5 LSM8 SLU7 SPTB SPTBN2	O15020 O95391 O95777 P11277 Q9Y4Y9 Q9Y4Z0	0:0:0:0:0:0	hu.MAP
	CRELD2 LSM4 LSM8 MAGOH SLU7 SPTBN2	O15020 O95391 O95777 P61326 Q6UXH1 Q9Y4Z0	0:0:0:0:0:0	hu.MAP
	KDM5C PBK SPTBN2 THTPA UBA5 USP5 ZFP91	O15020 P41229 P45974 Q96JP5 Q96KB5 Q9BU02 Q9GZZ9	0:0:0:0:0:0:0	Havugimana2012	Havugimana2012:C_533
	LSM7 RAD23A SPTBN2	O15020 P54725 Q9UK45	0:0:0	hu.MAP
	ACTB SPTBN2	O15020 P60709	6:6	PDB	PDB:6anu
	MAGOH SPTBN2	O15020 P61326	0:0	hu.MAP
	SPTAN1 SPTBN1 SPTBN2	O15020 Q01082 Q13813	0:0:0	hu.MAP2
	SPTBN2 TCEA2	O15020 Q15560	0:0	hu.MAP2

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	1	30550287

Sequence, Structure & Domains15

Sequences

Length

2,390

Mass

271,325

Sequence

MSSTLSPTDFDSLEIQGQYSDINNRWDLPDSDWDNDSSSARLFERSRIKALADEREAVQKKTFTKWVNSHLARVTCRVGDLYSDLRDGRNLLRLLEVLSGEILPKPTKGRMRIHCLENVDKALQFLKEQKVHLENMGSHDIVDGNHRLTLGLVWTIILRFQIQDISVETEDNKEKKSAKDALLLWCQMKTAGYPNVNVHNFTTSWRDGLAFNAIVHKHRPDLLDFESLKKCNAHYNLQNAFNLAEKELGLTKLLDPEDVNVDQPDEKSIITYVATYYHYFSKMKALAVEGKRIGKVLDHAMEAERLVEKYESLASELLQWIEQTIVTLNDRQLANSLSGVQNQLQSFNSYRTVEKPPKFTEKGNLEVLLFTIQSKLRANNQKVYTPREGRLISDINKAWERLEKAEHERELALRTELIRQEKLEQLAARFDRKAAMRETWLSENQRLVSQDNFGLELAAVEAAVRKHEAIETDIVAYSGRVQAVDAVAAELAAERYHDIKRIAARQHNVARLWDFLRQMVAARRERLLLNLELQKVFQDLLYLMDWMEEMKGRLQSQDLGRHLAGVEDLLQLHELVEADIAVQAERVRAVSASALRFCNPGKEYRPCDPQLVSERVAKLEQSYEALCELAAARRARLEESRRLWRFLWEVGEAEAWVREQQHLLASADTGRDLTGALRLLNKHTALRGEMSGRLGPLKLTLEQGQQLVAEGHPGASQASARAAELQAQWERLEALAEERAQRLAQAASLYQFQADANDMEAWLVDALRLVSSPELGHDEFSTQALARQHRALEEEIRSHRPTLDALREQAAALPPTLSRTPEVQSRVPTLERHYEELQARAGERARALEAALALYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLEVVQQRFETLEPEMNTLAAQITAVNDIAEQLLKANPPGKDRIVNTQEQLNHRWQQFRRLADGKKAALTSALSIQNYHLECTETQAWMREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARVGELTREANALAAGHPAQAVAINARLREVQTGWEDLRATMRRREESLGEARRLQDFLRSLDDFQAWLGRTQTAVASEEGPATLPEAEALLAQHAALRGEVERAQSEYSRLRALGEEVTRDQADPQCLFLRQRLEALGTGWEELGRMWESRQGRLAQAHGFQGFLRDARQAEGVLSSQEYVLSHTEMPGTLQAADAAIKKLEDFMSTMDANGERIHGLLEAGRQLVSEGNIHADKIREKADSIERRHKKNQDAAQQFLGRLRDNREQQHFLQDCHELKLWIDEKMLTAQDVSYDEARNLHTKWQKHQAFMAELAANKDWLDKVDKEGRELTLEKPELKALVSEKLRDLHRRWDELETTTQAKARSLFDANRAELFAQSCCALESWLESLQAQLHSDDYGKDLTSVNILLKKQQMLEWEMAVREKEVEAIQAQAKALAQEDQGAGEVERTSRAVEEKFRALCQPMRERCRRLQASREQHQFHRDVEDEILWVTERLPMASSMEHGKDLPSVQLLMKKNQTLQKEIQGHEPRIADLRERQRALGAAAAGPELAELQEMWKRLGHELELRGKRLEDALRAQQFYRDAAEAEAWMGEQELHMMGQEKAKDELSAQAEVKKHQVLEQALADYAQTIHQLAASSQDMIDHEHPESTRISIRQAQVDKLYAGLKELAGERRERLQEHLRLCQLRRELDDLEQWIQEREVVAASHELGQDYEHVTMLRDKFREFSRDTSTIGQERVDSANALANGLIAGGHAARATVAEWKDSLNEAWADLLELLDTRGQVLAAAYELQRFLHGARQALARVQHKQQQLPDGTGRDLNAAEALQRRHCAYEHDIQALSPQVQQVQDDGHRLQKAYAGDKAEEIGRHMQAVAEAWAQLQGSSAARRQLLLDTTDKFRFFKAVRELMLWMDEVNLQMDAQERPRDVSSADLVIKNQQGIKAEIEARADRFSSCIDMGKELLARSHYAAEEISEKLSQLQARRQETAEKWQEKMDWLQLVLEVLVFGRDAGMAEAWLCSQEPLVRSAELGCTVDEVESLIKRHEAFQKSAVAWEERFCALEKLTALEEREKERKRKREEEERRKQPPAPEPTASVPPGDLVGGQTASDTTWDGTQPRPPPSTQAPSVNGVCTDGEPSQPLLGQQRLEHSSFPEGPGPGSGDEANGPRGERQTRTRGPAPSAMPQSRSTESAHAATLPPRGPEPSAQEQMEGMLCRKQEMEAFGKKAANRSWQNVYCVLRRGSLGFYKDAKAASAGVPYHGEVPVSLARAQGSVAFDYRKRKHVFKLGLQDGKEYLFQAKDEAEMSSWLRVVNAAIATASSASGEPEEPVVPSTTRGMTRAMTMPPVSPVGAEGPVVLRSKDGREREREKRFSFFKKNK

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O15020-1; Sequence=Displayed; Name=2; IsoId=O15020-2; Sequence=VSP_000722

Alternative Sequence

2314..2390; AEMSSWLRVVNAAIATASSASGEPEEPVVPSTTRGMTRAMTMPPVSPVGAEGPVVLRSKDGREREREKRFSFFKKNK -> VSCPSCSSLSVPFQKLPAADSPSFPVLPLFPGLVLCGKTGCVRRPHQAALPV (in isoform 2)

3D Structural Models

Turn

220..222; 225..227; 256..258; 2265..2267

Helix

180..191; 209..218; 234..246; 266..282; 2261..2264; 2313..2328

Beta Strand

193..195; 205..208; 261..263; 283..285; 2221..2233; 2244..2251; 2254..2260; 2269..2272; 2282..2285; 2293..2299; 2301..2303; 2305..2309

3D Structure

Electron microscopy (1); NMR spectroscopy (2)

Domain & Motif Annotations

Compositional Bias

2081..2096; Basic and acidic residues; 2116..2125; Polar residues; 2370..2383; Basic and acidic residues

Repeat

306..414; Spectrin 1; 427..527; Spectrin 2; 532..639; Spectrin 3; 642..744; Spectrin 4; 749..849; Spectrin 5; 855..954; Spectrin 6; 960..1063; Spectrin 7; 1066..1169; Spectrin 8; 1174..1262; Spectrin 9; 1279..1379; Spectrin 10; 1384..1485; Spectrin 11; 1489..1586; Spectrin 12; 1589..1692; Spectrin 13; 1696..1797; Spectrin 14; 1801..1904; Spectrin 15; 1910..2010; Spectrin 16; 2017..2076; Spectrin 17

Domain (FT)

57..161; Calponin-homology (CH) 1; 176..281; Calponin-homology (CH) 2; 2218..2328; PH

Region

2..278; Actin-binding; 2081..2222; Disordered; 2331..2390; Disordered

Protein Families

Spectrin family

Sequence Similarities

Belongs to the spectrin family.

Clinical Relevance2

Disease Involvement (3)

Disease variantNeurodegenerationSpinocerebellar ataxia

Antibody (3)

CAB009844 HPA039293 HPA043529

Supporting Publications1

PMID	Title	Abstract
27601599	Comprehensive Proteomic Analysis of Human Milk-derived Extracellular Vesicles Unveils a Novel Functional Proteome Distinct from Other Milk Components.	No abstract available