Protein detail

PLXB2

Plexin-B2 (MM1)

Entry name PLXB2	UniProt ID O15031	EVMP confidence score 0.25
Supporting publications (n) 1	Transmembrane count 1	Protein classification Plasma proteinsPredicted intracellular proteinsPredicted membrane proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Plexin-B2 (MM1)

Protein Class (3)

Plasma proteinsPredicted intracellular proteinsPredicted membrane proteins

Protein Function

Predicted intracellular proteins

Transmembrane

1198..1218; Helical

Transmembrane Count

Ensembl

ENSG00000196576

Entrez Gene Symbol

PLXNB2

Gene Synonym (3)

KIAA0315MM1PLEXB2

Gene Description

Plexin B2

Chromosome

Position

50274979-50307646

Supporting publications (n)

EVMP confidence score

0.25

Fluorescence & Localization4

Tissue SpecificintestineCell SpecificColonocytesSingle-Nuclei Brain SpecificfibroblastBlood Cell Specificbasophil

Function & Pathway6

Protein Function

Predicted intracellular proteins

Cellular Component (4)

Molecular Function (3)

Biological Process (3)

KEGG

hsa04360 Axon guidance

Mediation Categories (2)

Adhesion and uptake mediationReceptor-signaling mediation

Relations & Evidence62

Ligand-Receptor Signaling (58)

58 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	CellPhoneDB	No	Yes	No	Yes	No
receptor	receptor	GO_Intercell	No	Yes	No	Yes	No
receptor	receptor	HPMR	No	Yes	No	Yes	No
receptor	receptor	ICELLNET	No	Yes	No	Yes	No
receptor	receptor	CellChatDB	No	Yes	No	Yes	No
receptor	receptor	CellTalkDB	No	Yes	No	Yes	No
receptor	receptor	Surfaceome	No	Yes	No	Yes	No
receptor	receptor	Ramilowski2015	No	Yes	No	Yes	No
receptor	receptor	LRdb	No	Yes	No	Yes	No
receptor	receptor	Baccin2019	No	Yes	No	Yes	No

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Protein Complex Composition (3)

3 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
C1orf198 DAAM1 PLXNB2 RHOD	O00212 O15031 Q9H425 Q9Y4D1	0:0:0:0	hu.MAP
ACO1 C12orf57 FKBP7 NIF3L1 NT5DC1 PLXNB2 S100A11 SRM TACC1 UBE2F	O15031 O75410 P19623 P21399 P31949 Q5TFE4 Q969M7 Q99622 Q9GZT8 Q9Y680	0:0:0:0:0:0:0:0:0:0	Havugimana2012	Havugimana2012:C_592
CD320 PLXNB2 TMX1	O15031 Q9H3N1 Q9NPF0	0:0:0	hu.MAP2

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationDensity Gradient CentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion ChromatographyImmunoaffinity CaptureMicrofluidics-Based Methods	Mass spectrometryMass spectrometry [LTQ-FT Ultra]R Sequencing	114	31685984 33718342 34401050 34622320 34754007 34889606 36406491 37862381 38173217 38441169 38937789 38938674 39949490 40928027 39766158 23376485 26538482 28054239 31508500 34071777 34108659 38225453 38556629 39436214 39873726 10451508 40945317 41227296 40545963 40185859 39505756 39443544 37702715 34064456 32795414 30382917 29562735 28562335 38731868 26775013 40142159 24700864 33806028 4001484 22329422 22867456 2353145 23585444 24733759 25471207 25844599 25950383 26801919 26884841 27605433 27723984 28242843 28963552 29242380 30071318 30287549 30353492 30536821 30550287 30608700 31694344 32295833 32927759 33017416 33580265 33709510 33729255 34202855 37926697 38031074 39022990 40619995 41019078 20224111 22418980 27312428 27320496 30975894 31065972 36635400 37686366 38164498 38490958 39569406 40925068 41201090 34186243 34131392 21362503 28369848 28396511 30760538 35085587 31320591 31366407 39001700 33905554 40311616 39835386 40091455 38136601 34355211 33114768 38612515 38564289 41315767 36332889 24069378 33017416

Sequence, Structure & Domains9

Sequences

Length

1,838

Mass

205,127

Sequence

MALQLWALTLLGLLGAGASLRPRKLDFFRSEKELNHLAVDEASGVVYLGAVNALYQLDAKLQLEQQVATGPALDNKKCTPPIEASQCHEAEMTDNVNQLLLLDPPRKRLVECGSLFKGICALRALSNISLRLFYEDGSGEKSFVASNDEGVATVGLVSSTGPGGDRVLFVGKGNGPHDNGIIVSTRLLDRTDSREAFEAYTDHATYKAGYLSTNTQQFVAAFEDGPYVFFVFNQQDKHPARNRTLLARMCREDPNYYSYLEMDLQCRDPDIHAAAFGTCLAASVAAPGSGRVLYAVFSRDSRSSGGPGAGLCLFPLDKVHAKMEANRNACYTGTREARDIFYKPFHGDIQCGGHAPGSSKSFPCGSEHLPYPLGSRDGLRGTAVLQRGGLNLTAVTVAAENNHTVAFLGTSDGRILKVYLTPDGTSSEYDSILVEINKRVKRDLVLSGDLGSLYAMTQDKVFRLPVQECLSYPTCTQCRDSQDPYCGWCVVEGRCTRKAECPRAEEASHWLWSRSKSCVAVTSAQPQNMSRRAQGEVQLTVSPLPALSEEDELLCLFGESPPHPARVEGEAVICNSPSSIPVTPPGQDHVAVTIQLLLRRGNIFLTSYQYPFYDCRQAMSLEENLPCISCVSNRWTCQWDLRYHECREASPNPEDGIVRAHMEDSCPQFLGPSPLVIPMNHETDVNFQGKNLDTVKGSSLHVGSDLLKFMEPVTMQESGTFAFRTPKLSHDANETLPLHLYVKSYGKNIDSKLHVTLYNCSFGRSDCSLCRAANPDYRCAWCGGQSRCVYEALCNTTSECPPPVITRIQPETGPLGGGIRITILGSNLGVQAGDIQRISVAGRNCSFQPERYSVSTRIVCVIEAAETPFTGGVEVDVFGKLGRSPPNVQFTFQQPKPLSVEPQQGPQAGGTTLTIHGTHLDTGSQEDVRVTLNGVPCKVTKFGAQLQCVTGPQATRGQMLLEVSYGGSPVPNPGIFFTYRENPVLRAFEPLRSFASGGRSINVTGQGFSLIQRFAMVVIAEPLQSWQPPREAESLQPMTVVGTDYVFHNDTKVVFLSPAVPEEPEAYNLTVLIEMDGHRALLRTEAGAFEYVPDPTFENFTGGVKKQVNKLIHARGTNLNKAMTLQEAEAFVGAERCTMKTLTETDLYCEPPEVQPPPKRRQKRDTTHNLPEFIVKFGSREWVLGRVEYDTRVSDVPLSLILPLVIVPMVVVIAVSVYCYWRKSQQAEREYEKIKSQLEGLEESVRDRCKKEFTDLMIEMEDQTNDVHEAGIPVLDYKTYTDRVFFLPSKDGDKDVMITGKLDIPEPRRPVVEQALYQFSNLLNSKSFLINFIHTLENQREFSARAKVYFASLLTVALHGKLEYYTDIMHTLFLELLEQYVVAKNPKLMLRRSETVVERMLSNWMSICLYQYLKDSAGEPLYKLFKAIKHQVEKGPVDAVQKKAKYTLNDTGLLGDDVEYAPLTVSVIVQDEGVDAIPVKVLNCDTISQVKEKIIDQVYRGQPCSCWPRPDSVVLEWRPGSTAQILSDLDLTSQREGRWKRVNTLMHYNVRDGATLILSKVGVSQQPEDSQQDLPGERHALLEEENRVWHLVRPTDEVDEGKSKRGSVKEKERTKAITEIYLTRLLSVKGTLQQFVDNFFQSVLAPGHAVPPAVKYFFDFLDEQAEKHNIQDEDTIHIWKTNSLPLRFWVNILKNPHFIFDVHVHEVVDASLSVIAQTFMDACTRTEHKLSRDSPSNKLLYAKEISTYKKMVEDYYKGIRQMVQVSDQDMNTHLAEISRAHTDSLNTLVALHQLYQYTQKYYDEIINALEEDPAAQKMQLAFRLQQIAAALENKVTDL

3D Structural Models

Helix

1487..1498; 1545..1548

Beta Strand

1462..1469; 1477..1482; 1512..1517; 1555..1560

3D Structure

X-ray crystallography (1)

Domain & Motif Annotations

Domain (FT)

20..466; Sema; 803..893; IPT/TIG 1; 895..980; IPT/TIG 2; 983..1092; IPT/TIG 3

Protein Families

Plexin family

Sequence Similarities

Belongs to the plexin family.

Clinical Relevance4

Antibody

HPA003100

Interaction Protein

ENSG00000173156

Interaction Count

Interaction Dataset

biogrid_bioplex

Supporting Publications1

PMID	Title	Abstract
34889606	Surface Nanosieving Polyether Sulfone Particles with Graphene Oxide Encapsulation for the Negative Isolation toward Extracellular Vesicles.	No abstract available