Protein detail
ARHGB
Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF)
Protein symbol ARHGB | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count | Protein classification Predicted intracellular proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF)
Protein Class
Predicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
GTRAP48KIAA0380PDZ-RHOGEF
Gene Description
Rho guanine nucleotide exchange factor 11
Chromosome
1
Position
156934840-157045742
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Cell SpecificEndometrial luminal cellsSingle-Nuclei Brain SpecificastrocyteBlood Lineage SpecificNK-cells
Function & Pathway
Protein Function
Predicted intracellular proteins
Cellular Component
Molecular Function
Biological Process
KEGG
Reactome
- R-hsa-9013148 cdc42 gtpase cycle
- R-hsa-204998 cell death signalling via nrage nrif and nade
- R-hsa-73887 death receptor signaling
- R-hsa-416482 g alpha 12 13 signalling events
- R-hsa-9675108 nervous system development
- R-hsa-193648 nrage signals death through jnk
- R-hsa-193704 p75 ntr receptor mediated signalling
- R-hsa-9013149 rac1 gtpase cycle
- R-hsa-8980692 rhoa gtpase cycle
- R-hsa-9013026 rhob gtpase cycle
- R-hsa-9013106 rhoc gtpase cycle
- R-hsa-9012999 rho gtpase cycle
- R-hsa-416572 sema4d induced cell migration and growth cone collapse
- R-hsa-400685 sema4d in semaphorin signaling
- R-hsa-373755 semaphorin interactions
- R-hsa-372790 signaling by gpcr
- R-hsa-9716542 signaling by rho gtpases miro gtpases and rhobtb3
Canonical Pathways
M167 Pid ap1 pathway
Mediation Categories
Receptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
5 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
3 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| ARHGB | O15085 | RHOA | P61586 | Yes | Yes | No | WangKEGG-MEDICUSSIGNORHPRDCui2007HINTIntActDIPSPIKE_LCLit-BM-17 | Lit-BM-17:20300064HPRD:10526156SPIKE_LC:17145710DIP:15530360HPRD:15530360Lit-BM-17:15530360Lit-BM-17:21988832Lit-BM-17:10526156IntAct:20300064HINT:32203420SIGNOR:32203420HINT:20300064IntAct:21988832HINT:33961781HINT:15530360HINT:20430886HINT:21816819HINT:34591642IntAct:15530360HINT:10526156 |
| GNA13 | Q14344 | ARHGB | O15085 | Yes | Yes | No | KEGG-MEDICUSHPRDSIGNORBioGRID | HPRD:10026210SIGNOR:11799111BioGRID:10026210 |
| GNA12 | Q03113 | ARHGB | O15085 | Yes | Yes | No | KEGG-MEDICUSHPRDSIGNOR | SIGNOR:11799111HPRD:10026210 |
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometry | 1 | 40326690 |
Sequence, Structure & Domains
Sequences
Length
1,522
Mass
167,704
Sequence
MSVRLPQSIDRLSSLSSLGDSAPERKSPSHHRQPSDASETTGLVQRCVIIQKDQHGFGFTVSGDRIVLVQSVRPGGAAMKAGVKEGDRIIKVNGTMVTNSSHLEVVKLIKSGAYVALTLLGSSPSSMGISGLQQDPSPAGAPRITSVIPSPPPPPPLPPPQRITGPKPLQDPEVQKHATQILRNMLRQEEKELQDILPLYGDTSQRPSEGRLSLDSQEGDSGLDSGTERFPSLSESLMNRNSVLSDPGLDSPRTSPVIMARVAQHHRRQGSDAAVPSTGDQGVDQSPKPLIIGPEEDYDPGYFNNESDIIFQDLEKLKSRPAHLGVFLRYIFSQADPSPLLFYLCAEVYQQASPKDSRSLGKDIWNIFLEKNAPLRVKIPEMLQAEIDSRLRNSEDARGVLCEAQEAAMPEIQEQIHDYRTKRTLGLGSLYGENDLLDLDGDPLRERQVAEKQLAALGDILSKYEEDRSAPMDFALNTYMSHAGIRLREARPSNTAEKAQSAPDKDKWLPFFPKTKKSSNSKKEKDALEDKKRNPILKYIGKPKSSSQSTFHIPLSPVEVKPGNVRNIIQHFENNQQYDAPEPGTQRLSTGSFPEDLLESDSSRSEIRLGRSESLKGREEMKRSRKAENVPRSRSDVDMDAAAEATRLHQSASSSTSSLSTRSLENPTPPFTPKMGRRSIESPSLGFCTDTLLPHLLEDDLGQLSDLEPEPDAQNWQHTVGKDVVAGLTQREIDRQEVINELFVTEASHLRTLRVLDLIFYQRMKKENLMPREELARLFPNLPELIEIHNSWCEAMKKLREEGPIIKEISDLMLARFDGPAREELQQVAAQFCSYQSIALELIKTKQRKESRFQLFMQEAESHPQCRRLQLRDLIISEMQRLTKYPLLLESIIKHTEGGTSEHEKLCRARDQCREILKYVNEAVKQTENRHRLEGYQKRLDATALERASNPLAAEFKSLDLTTRKMIHEGPLTWRISKDKTLDLHVLLLEDLLVLLQKQDEKLLLKCHSKTAVGSSDSKQTFSPVLKLNAVLIRSVATDKRAFFIICTSKLGPPQIYELVALTSSDKNTWMELLEEAVRNATRHPGAAPMPVHPPPPGPREPAQQGPTPSRVELDDSDVFHGEPEPEELPGGTGSQQRVQGKHQVLLEDPEQEGSAEEEELGVLPCPSTSLDGENRGIRTRNPIHLAFPGPLFMEGLADSALEDVENLRHLILWSLLPGHTMETQAAQEPEDDLTPTPSVISVTSHPWDPGSPGQAPPGGEGDNTQLAGLEGERPEQEDMGLCSLEHLPPRTRNSGIWESPELDRNLAEDASSTEAAGGYKVVRKAEVAGSKVVPALPESGQSEPGPPEVEGGTKATGNCFYVSMPSGPPDSSTDHSEAPMSPPQPDSLPAGQTEPQPQLQGGNDDPRRPSRSPPSLALRDVGMIFHTIEQLTLKLNRLKDMELAHRELLKSLGGESSGGTTPVGSFHTEAARWTDGSLSPPAKEPLASDSRNSHELGPCPEDGSDAPLEDSTADAAASPGP
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O15085-1; Sequence=Displayed; Name=2; IsoId=O15085-2; Sequence=VSP_042003
Alternative Sequence
194; Q -> QRICEVYSRNPASLLEEQIEGARRRVTQLQLKIQQETGGSV (in isoform 2)
3D Structural Models
Turn
432..434; 944..946
Helix
77..80; 102..110; 307..312; 314..319; 321..334; 338..349; 356..368; 381..392; 398..424; 428..431; 435..438; 443..462; 466..482; 730..759; 761..766; 772..778; 782..801; 810..817; 819..833; 836..849; 851..862; 864..866; 871..874; 877..894; 901..939; 951..956; 961..963; 1028..1030; 1064..1080
Beta Strand
41..51; 53..56; 59..62; 64..66; 68..72; 74..76; 88..92; 98..100; 112..126; 716..725; 779..781; 966..975; 977..979; 981..999; 1002..1004; 1024..1027; 1031..1035; 1042..1047; 1050..1052; 1057..1060
3D Structure
NMR spectroscopy (1); X-ray crystallography (8)
Domain & Motif Annotations
Compositional Bias
149..161; Pro residues; 521..533; Basic and acidic residues; 601..637; Basic and acidic residues; 651..664; Low complexity; 1091..1100; Pro residues; 1112..1124; Basic and acidic residues; 1236..1245; Polar residues; 1338..1353; Low complexity; 1503..1513; Acidic residues
Coiled Coil
444..470
Domain (CC)
The poly-Pro region is essential for plasma membrane localization upon stimulation.
Domain (FT)
47..126; PDZ; 306..486; RGSL; 734..923; DH; 965..1079; PH
Region
1..40; Disordered; 128..175; Disordered; 200..231; Disordered; 263..286; Disordered; 490..555; Disordered; 573..680; Disordered; 1084..1141; Disordered; 1223..1320; Disordered; 1332..1423; Disordered; 1453..1522; Disordered