Protein detail
PLS1
Phospholipid scramblase 1 (PL scramblase 1) (Ca(2+)-dependent phospholipid scramblase 1) (Erythrocyte phospholipid scramblase) (Mg(2+)-dependent nuclease) (EC 3.1.-.-) (MmTRA1b)
Entry name PLS1 | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count 1 | Protein classification Predicted intracellular proteinsTransporters |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Phospholipid scramblase 1 (PL scramblase 1) (Ca(2+)-dependent phospholipid scramblase 1) (Erythrocyte phospholipid scramblase) (Mg(2+)-dependent nuclease) (EC 3.1.-.-) (MmTRA1b)
Protein Class
Predicted intracellular proteinsTransporters
Protein Function
- Transporters
- Predicted intracellular proteins
Transmembrane
289..305; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
MMTRA1B
Gene Description
Phospholipid scramblase 1
Chromosome
3
Position
146515180-146544856
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Tissue Specificstomach 1Brain Regional SpecificcerebellumCell SpecificParietal cellsSingle-Nuclei Brain Specificcerebellar inhibitory
Function & Pathway
Protein Function
- Transporters
- Predicted intracellular proteins
Cellular Component
- GO:0005634 nucleus
- GO:0005654 nucleoplasm
- GO:0005730 nucleolus
- GO:0005737 cytoplasm
- GO:0005794 Golgi apparatus
- GO:0005829 cytosol
- GO:0005886 plasma membrane
- GO:0016020 membrane
- GO:0045121 membrane raft
- GO:0048471 perinuclear region of cytoplasm
- GO:0062023 collagen-containing extracellular matrix
- GO:0070062 extracellular exosome
Molecular Function
- GO:0000287 magnesium ion binding
- GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
- GO:0001618 virus receptor activity
- GO:0003677 DNA binding
- GO:0004518 nuclease activity
- GO:0005154 epidermal growth factor receptor binding
- GO:0005509 calcium ion binding
- GO:0005515 protein binding
- GO:0008270 zinc ion binding
- GO:0017124 SH3 domain binding
- GO:0017128 phospholipid scramblase activity
- GO:0019899 enzyme binding
- GO:0032791 lead ion binding
- GO:0042609 CD4 receptor binding
- GO:0045340 mercury ion binding
Biological Process
Mediation Categories
Fusion and delivery mediationImmune mediationMetabolism mediation
Relations & Evidence
Enzyme-Mediated Modification
6 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| PLSCR1 | ABL1 | P00519 | Y | 74 | phosphorylation | BEL-Large-Corpus_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperdbPTMKEAphosphoELMLi2012SIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | KEA:11390389ProtMapper:15212693phosphoELM:11390389ProtMapper:11390389KEA:12871937dbPTM:11390389SIGNOR:11390389 |
| PLSCR1 | ABL1 | P00519 | Y | 69 | phosphorylation | BEL-Large-Corpus_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperdbPTMKEAphosphoELMLi2012SIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | KEA:11390389ProtMapper:15212693phosphoELM:11390389ProtMapper:11390389KEA:12871937dbPTM:11390389SIGNOR:11390389 |
| PLSCR1 | SRC | P12931 | Y | 74 | phosphorylation | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperKEAphosphoELMLi2012SIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | KEA:11390389ProtMapper:12871937SIGNOR:12871937KEA:12871937phosphoELM:12871937 |
| PLSCR1 | SRC | P12931 | Y | 69 | phosphorylation | BEL-Large-Corpus_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperKEAphosphoELMLi2012SIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | KEA:11390389ProtMapper:15212693SIGNOR:12871937KEA:12871937ProtMapper:12871937phosphoELM:12871937 |
| PLSCR1 | PRKCD | Q05655 | T | 161 | phosphorylation | PhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperHPRDKEASIGNOR_ProtMapperPhosphoSite | ProtMapper:10770950HPRD:10770950KEA:10770950SIGNOR:10770950 |
| PLSCR1 | CSK | P41240 | Y | 74 | phosphorylation | Sparser_ProtMapperProtMapper | ProtMapper:23259795 |
Ligand-Receptor Signaling
14 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| ecm | ecm | CellCellInteractions | Yes | No | No | No | No |
| ecm | ecm | OmniPath | Yes | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_topology | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_keyword | No | No | No | No | No |
| transmembrane | transmembrane | OmniPath | No | No | No | No | No |
Page 1 of 2Next
Regulatory Interaction Network
3 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| SRC | P12931 | PLS1 | O15162 | Yes | Yes | No | HPRD_MIMPSIGNORProtMapperPhosphoSite_KEAphosphoELM_KEALi2012Cui2007CancerCellMapWangPhosphoSite_ProtMapperBEL-Large-Corpus_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPiPTMnetKEAphosphoELMSIGNOR_ProtMapperSparser_ProtMapperSPIKE_LCSPIKE | KEA:11390389ProtMapper:15212693CancerCellMap:12871937phosphoELM:12871937SIGNOR:12871937KEA:12871937SPIKE:12871937ProtMapper:12871937ProtMapper:23259795SPIKE_LC:12871937 |
| ABL1 | P00519 | PLS1 | O15162 | Yes | Yes | No | HPRD_MIMPSIGNORProtMapperdbPTMPhosphoSite_KEAphosphoELM_KEALi2012HPRDWangPhosphoSite_ProtMapperBEL-Large-Corpus_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPiPTMnetPhosphoPointKEAHPRD_KEAphosphoELMSIGNOR_ProtMapperPhosphoSiteSPIKE_LCSPIKE | KEA:11390389ProtMapper:15212693PhosphoSite:12871937HPRD:11390389SPIKE_LC:20841568SPIKE:11390389phosphoELM:11390389PhosphoSite:11390389SPIKE_LC:11390389ProtMapper:11390389dbPTM:11390389KEA:12871937SPIKE:20841568PhosphoSite:32292520SIGNOR:11390389 |
| KPCD | Q05655 | PLS1 | O15162 | Yes | Yes | No | Sparser_ProtMapperPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDPhosphoSite_KEAKEAHPRD_KEASIGNOR_ProtMapperHPRD-phos | HPRD:10770950ProtMapper:29748552HPRD-phos:10770950ProtMapper:10770950SIGNOR:10770950KEA:10770950 |
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Size Exclusion Chromatography | Mass spectrometry | 1 | 31414377 |
Sequence, Structure & Domains
Sequences
Length
318
Mass
35,049
Sequence
MDKQNSQMNASHPETNLPVGYPPQYPPTAFQGPPGYSGYPGPQVSYPPPPAGHSGPGPAGFPVPNQPVYNQPVYNQPVGAAGVPWMPAPQPPLNCPPGLEYLSQIDQILIHQQIELLEVLTGFETNNKYEIKNSFGQRVYFAAEDTDCCTRNCCGPSRPFTLRIIDNMGQEVITLERPLRCSSCCCPCCLQEIEIQAPPGVPIGYVIQTWHPCLPKFTIQNEKREDVLKISGPCVVCSCCGDVDFEIKSLDEQCVVGKISKHWTGILREAFTDADNFGIQFPLDLDVKMKAVMIGACFLIDFMFFESTGSQEQKSGVW
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O15162-1; Sequence=Displayed; Name=2; IsoId=O15162-2; Sequence=VSP_055237, VSP_055238
Alternative Sequence
1..23; MDKQNSQMNASHPETNLPVGYPP -> MLLTRKQTCQLGILLSIHRQHSK (in isoform 2); 24..104; Missing (in isoform 2)
3D Structural Models
3D Structure
X-ray crystallography (1)
Domain & Motif Annotations
Compositional Bias
1..14; Polar residues; 31..44; Low complexity
Motif
18..26; SH3-binding 1; 22..25; PPXY motif 1; 33..36; PPXY motif 2; 42..50; SH3-binding 2; 84..92; SH3-binding 3; 257..266; Nuclear localization signal
Domain (CC)
The N-terminal proline-rich domain (PRD) is required for phospholipid scramblase activity.; DOMAIN: The transmembrane domain is essential for membrane insertion, phospholipid scramblase activity and proper calcium-binding.
Region
1..84; Proline-rich domain (PRD); 1..64; Disordered; 99..290; Interaction with hepatitis C virus E2 glycoprotein
Protein Families
Phospholipid scramblase family
Sequence Similarities
Belongs to the phospholipid scramblase family.