Protein detail
S22A2
Solute carrier family 22 member 2 (Organic cation transporter 2) (hOCT2)
Protein symbol S22A2 | UniProt ID | EVMP score 0.38 |
Frequency | Transmembrane count 12 | Protein classification Metabolic proteinsPredicted membrane proteinsTransporters |
Basic Information
Protein Names
Solute carrier family 22 member 2 (Organic cation transporter 2) (hOCT2)
Protein Class
Metabolic proteinsPredicted membrane proteinsTransporters
Protein Function
Transporters:Electrochemical Potential-driven transporters
Transmembrane
23..43; Helical; 151..171; Helical; 178..198; Helical; 209..229; Helical; 239..259; Helical; 264..284; Helical; 349..369; Helical; 376..396; Helical; 415..435; Helical; 442..462; Helical; 465..485; Helical; 495..515; Helical
Transmembrane Count
12
Ensembl
Entrez Gene Symbol
Gene Synonym
OCT2
Gene Description
Solute carrier family 22 member 2
Chromosome
6
Position
160171061-160277638
EVMP Score
0.38
Fluorescence & Localization
Tissue SpecificbrainCell SpecificAdipocytesSingle-Nuclei Brain Specificfibroblast
Function & Pathway
Protein Function
Transporters:Electrochemical Potential-driven transporters
Cellular Component
Molecular Function
- GO:0005275 amine transmembrane transporter activity
- GO:0005277 acetylcholine transmembrane transporter activity
- GO:0005326 neurotransmitter transmembrane transporter activity
- GO:0008504 monoamine transmembrane transporter activity
- GO:0008514 organic anion transmembrane transporter activity
- GO:0015101 organic cation transmembrane transporter activity
- GO:0015132 prostaglandin transmembrane transporter activity
- GO:0015179 L-amino acid transmembrane transporter activity
- GO:0015214 pyrimidine nucleoside transmembrane transporter activity
- GO:0015220 choline transmembrane transporter activity
- GO:0015234 thiamine transmembrane transporter activity
- GO:0015489 putrescine transmembrane transporter activity
- GO:0015562 efflux transmembrane transporter activity
- GO:0015606 spermidine transmembrane transporter activity
- GO:0015651 quaternary ammonium group transmembrane transporter activity
- GO:0019534 toxin transmembrane transporter activity
- GO:0042910 xenobiotic transmembrane transporter activity
- GO:0061459 L-arginine transmembrane transporter activity
Biological Process
Reactome
- R-hsa-2161522 abacavir adme
- R-hsa-2161517 abacavir transmembrane transport
- R-hsa-9748784 drug adme
- R-hsa-112316 neuronal system
- R-hsa-112311 neurotransmitter clearance
- R-hsa-112310 neurotransmitter release cycle
- R-hsa-181430 norepinephrine neurotransmitter release cycle
- R-hsa-425407 slc mediated transmembrane transport
- R-hsa-442660 slc mediated transport of neurotransmitters
- R-hsa-549127 slc mediated transport of organic cations
- R-hsa-112315 transmission across chemical synapses
- R-hsa-382551 transport of small molecules
Canonical Pathways
- M16 Pid insulin pathway
- M67 Pid arf6 trafficking pathway
Mediation Categories
Clinical-translation mediationFusion and delivery mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
27 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane | transmembrane | UniProt_topology | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_keyword | No | No | No | No | No |
| transmembrane | transmembrane | TopDB | No | No | No | No | No |
| transmembrane | transmembrane | LOCATE | No | No | No | No | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | No | No | No |
| transmembrane | transmembrane | OmniPath | No | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| basolateral_cell_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| basal_cell_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| apical_cell_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
Regulatory Interaction Network
0 records.
Protein Complex Composition
0 records.
Sequence, Structure & Domains
Sequences
Length
555
Mass
62,581
Sequence
MPTTVDDVLEHGGEFHFFQKQMFFLLALLSATFAPIYVGIVFLGFTPDHRCRSPGVAELSLRCGWSPAEELNYTVPGPGPAGEASPRQCRRYEVDWNQSTFDCVDPLASLDTNRSRLPLGPCRDGWVYETPGSSIVTEFNLVCANSWMLDLFQSSVNVGFFIGSMSIGYIADRFGRKLCLLTTVLINAAAGVLMAISPTYTWMLIFRLIQGLVSKAGWLIGYILITEFVGRRYRRTVGIFYQVAYTVGLLVLAGVAYALPHWRWLQFTVSLPNFFFLLYYWCIPESPRWLISQNKNAEAMRIIKHIAKKNGKSLPASLQRLRLEEETGKKLNPSFLDLVRTPQIRKHTMILMYNWFTSSVLYQGLIMHMGLAGDNIYLDFFYSALVEFPAAFMIILTIDRIGRRYPWAASNMVAGAACLASVFIPGDLQWLKIIISCLGRMGITMAYEIVCLVNAELYPTFIRNLGVHICSSMCDIGGIITPFLVYRLTNIWLELPLMVFGVLGLVAGGLVLLLPETKGKALPETIEEAENMQRPRKNKEKMIYLQVQKLDIPLN
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=O15244-1; Sequence=Displayed; Name=2; Synonyms=OCT2-A; IsoId=O15244-2; Sequence=VSP_031773, VSP_031774; Name=3; IsoId=O15244-3; Sequence=VSP_031771, VSP_031772
Alternative Sequence
225..242; ITEFVGRRYRRTVGIFYQ -> SKNVCACNCENKATSLPK (in isoform 3); 243..555; Missing (in isoform 3); 427..483; DLQWLKIIISCLGRMGITMAYEIVCLVNAELYPTFIRNLGVHICSSMCDIGGIITPF -> GKFQVKLESYLQDPGERECHGPLIGKPCNLSSKSIWKDKLEGSIWDPSEQIHMASLL (in isoform 2); 484..555; Missing (in isoform 2)
3D Structural Models
3D Structure
Electron microscopy (1)
Domain & Motif Annotations
Motif
284..288; Proline-rich sequence
Domain (CC)
Contains one proline-rich sequence (Pro-Glu-Ser-Pro-Arg) that may be involved in tyrosine-protein kinase YES1 binding and is required for the activation of substrate transport.
Protein Families
- Major facilitator (TC 2.A.1) superfamily
- Organic cation transporter (TC 2.A.1.19) family
Sequence Similarities
Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
Clinical Relevance
Interaction Protein
ENSG00000151348
Interaction Count
1
Interaction Dataset
intact_biogrid