EV MemProt Atlas

Basic Information

Protein Names

Polyunsaturated fatty acid lipoxygenase ALOX15B (15-lipoxygenase 2) (15-LOX-2) (Arachidonate 15-lipoxygenase B) (15-LOX-B) (EC 1.13.11.33) (Arachidonate 15-lipoxygenase type II) (Linoleate 13-lipoxygenase 15-LOb) (EC 1.13.11.-)

Protein Class

EnzymesMetabolic proteinsPredicted intracellular proteins

Protein Function

Enzymes
ENZYME proteins:Oxidoreductases
Predicted intracellular proteins

Ensembl

ENSG00000179593

Entrez Gene Symbol

ALOX15B

Gene Synonym

15-LOX-2

Gene Description

Arachidonate 15-lipoxygenase type B

Chromosome

17

Position

8039034-8049134

Frequency

2

EVMP Score

0.50

Fluorescence & Localization

Tissue SpecificbrainCell SpecificAstrocytes

Function & Pathway

Protein Function

Enzymes
ENZYME proteins:Oxidoreductases
Predicted intracellular proteins

Cellular Component

Molecular Function

Biological Process

KEGG

Reactome

Canonical Pathways

M16 Pid insulin pathway
M67 Pid arf6 trafficking pathway
M81 Pid cdc42 pathway

Mediation Categories

Adhesion and uptake mediationFusion and delivery mediationMetabolism mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

7 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	OmniPath	No	Yes	No	No	No
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
receptor	receptor	scConnect	No	Yes	No	No	No

Regulatory Interaction Network

0 records.

Protein Complex Composition

2 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	ALOX15B	O15296	2	PDB	PDB:7laf
	ALOX15B KBTBD2	O15296 Q8IY47	0:0	hu.MAP2

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Western BlottingMass SpectrometryFlow Cytometry	1	38207106

Sequence, Structure & Domains

Sequences

Length

676

Mass

75,857

Sequence

MAEFRVRVSTGEAFGAGTWDKVSVSIVGTRGESPPLPLDNLGKEFTAGAEEDFQVTLPEDVGRVLLLRVHKAPPVLPLLGPLAPDAWFCRWFQLTPPRGGHLLFPCYQWLEGAGTLVLQEGTAKVSWADHHPVLQQQRQEELQARQEMYQWKAYNPGWPHCLDEKTVEDLELNIKYSTAKNANFYLQAGSAFAEMKIKGLLDRKGLWRSLNEMKRIFNFRRTPAAEHAFEHWQEDAFFASQFLNGLNPVLIRRCHYLPKNFPVTDAMVASVLGPGTSLQAELEKGSLFLVDHGILSGIQTNVINGKPQFSAAPMTLLYQSPGCGPLLPLAIQLSQTPGPNSPIFLPTDDKWDWLLAKTWVRNAEFSFHEALTHLLHSHLLPEVFTLATLRQLPHCHPLFKLLIPHTRYTLHINTLARELLIVPGQVVDRSTGIGIEGFSELIQRNMKQLNYSLLCLPEDIRTRGVEDIPGYYYRDDGMQIWGAVERFVSEIIGIYYPSDESVQDDRELQAWVREIFSKGFLNQESSGIPSSLETREALVQYVTMVIFTCSAKHAAVSAGQFDSCAWMPNLPPSMQLPPPTSKGLATCEGFIATLPPVNATCDVILALWLLSKEPGDQRPLGTYPDEHFTEEAPRRSIATFQSRLAQISRGIQERNQGLVLPYTYLDPPLIENSVSI

Alternative Products

Event=Alternative splicing; Named isoforms=4; Name=A; Synonyms=15-LOb1; IsoId=O15296-1; Sequence=Displayed; Name=B; Synonyms=15-LOX2sv-b; IsoId=O15296-2; Sequence=VSP_003142, VSP_003143; Name=C; Synonyms=15-LOX2sv-c; IsoId=O15296-3; Sequence=VSP_003144, VSP_003145; Name=D; Synonyms=15-LOX2sv-a, 15-LOb2; IsoId=O15296-4; Sequence=VSP_003142

Alternative Sequence

401..429; Missing (in isoform B and isoform D); 483..527; Missing (in isoform B); 561..617; FDSCAWMPNLPPSMQLPPPTSKGLATCEGFIATLPPVNATCDVILALWLLSKEPGDQ -> VRKGQRPRWQAGGDPAPQPHSALSAFSLTPVLGCPTCHPACSCHHPPPKAWQHARAS (in isoform C); 618..676; Missing (in isoform C)

3D Structural Models

Turn

77..79; 126..128; 172..174; 199..202; 231..233; 321..323; 519..522; 567..569

Helix

132..148; 167..169; 178..198; 212..215; 216..219; 223..230; 235..244; 265..272; 278..283; 293..295; 350..370; 371..378; 379..391; 397..402; 403..406; 409..419; 426..430; 434..448; 451..453; 456..462; 472..495; 499..504; 506..518; 524..526; 535..549; 551..557; 560..564; 587..593; 597..610; 631..655; 667..669

Beta Strand

2..10; 22..28; 50..59; 63..71; 86..95; 97..99; 102..113; 115..119; 161..163; 287..291; 314..319; 326..332; 334..336; 574..576; 580..583; 670..673

3D Structure

X-ray crystallography (3)

Domain & Motif Annotations

Domain (CC)

The PLAT domain can bind calcium ions; this promotes association with membranes.

Domain (FT)

2..124; PLAT; 125..676; Lipoxygenase

Protein Families

Lipoxygenase family

Sequence Similarities

Belongs to the lipoxygenase family.

Clinical Relevance

Drugs

HEXACHLOROPHENE EMBELIN JMR-132 N-ARACHIDONOYLGLYCINE SOMATORELIN BIM28011 CHEMBL:CHEMBL1448292 DIENESTROL HINOKITIOL EBSELEN SANGUINARINE SULFATE HEXESTROL METAMIZOLE SODIUM SANGUINARIUM FENTICLOR CHEMBL:CHEMBL238624 JUGLONE ASPIRIN TYRPHOSTIN 47 HYPERICIN PHENYLMERCURIC ACETATE CHEMBL:CHEMBL122701 CHEMBL:CHEMBL154580 4-CHLOROMERCURIBENZOIC ACID RABEPRAZOLE CHEMBL:CHEMBL242171 CHEMBL:CHEMBL1091971 CHEMBL:CHEMBL601616 THIMEROSAL CHEMBL:CHEMBL1367933 TROGLITAZONE AHPN CHEMBL:CHEMBL457504 MERCURIC CHLORIDE CAPSAZEPINE TESAMORELIN JI-38 GOSSYPOL LUTEOLIN CHEMBL:CHEMBL220845 LINOLENIC ACID CHEMBL:CHEMBL595227 PHENOTHIAZINE PICEATANNOL DIHYDROXIDINE PROTOPORPHYRIN CHEMBL:CHEMBL601952 PSEUDOEPHEDRINE SERMORELIN ETHOPROPAZINE HYDROCHLORIDE N,N'-DIPHENYL-P-PHENYLENEDIAMINE PYRITHIONE ZINC QUERCETIN AURINTRICARBOXYLIC ACID CHEMBL:CHEMBL602807 CONGO RED CHEMBL:CHEMBL581044 BITHIONOL BITHIONOLATE SODIUM TYRPHOSTIN 23 CAFFEIC ACID PHENETHYL ESTER E324 RHODOMYRTOXIN B CHELERYTHRINE TRICETIN MASOPROCOL 2-APB TYRPHOSTIN AG 879 4-METHOXYDALBERGIONE

Antibody

HPA010562

Protein symbol LX15B	UniProt ID O15296	EVMP score 0.50
Frequency 2	Transmembrane count	Protein classification EnzymesMetabolic proteinsPredicted intracellular proteins

LX15B