Protein detail
TMPS2
Transmembrane protease serine 2 (EC 3.4.21.122) (Serine protease 10) [Cleaved into: Transmembrane protease serine 2 non-catalytic chain; Transmembrane protease serine 2 catalytic chain]
Protein symbol TMPS2 | UniProt ID | EVMP score 0.50 |
Frequency 2 | Transmembrane count 1 | Protein classification Cancer-related genesEnzymesPredicted intracellular proteinsPredicted membrane proteinsPredicted secreted proteinsTransporters |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Transmembrane protease serine 2 (EC 3.4.21.122) (Serine protease 10) [Cleaved into: Transmembrane protease serine 2 non-catalytic chain; Transmembrane protease serine 2 catalytic chain]
Protein Class
Cancer-related genesEnzymesPredicted intracellular proteinsPredicted membrane proteinsPredicted secreted proteinsTransporters
Protein Function
- Predicted intracellular proteins
- Peptidases:Serine-type peptidases
- Enzymes
- Cancer-related genes:Candidate cancer biomarkers
- Predicted secreted proteins
- Transporters:Accessory Factors Involved in Transport
Transmembrane
85..105; Helical; Signal-anchor for type II membrane protein
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
PRSS10
Gene Description
Transmembrane serine protease 2
Chromosome
21
Position
41464300-41531116
Frequency
2
EVMP Score
0.50
Fluorescence & Localization
Cell SpecificRetinal horizontal cellsBlood Cell SpecificgdT-cellBlood Lineage SpecificNK-cells
Function & Pathway
Protein Function
- Predicted intracellular proteins
- Peptidases:Serine-type peptidases
- Enzymes
- Cancer-related genes:Candidate cancer biomarkers
- Predicted secreted proteins
- Transporters:Accessory Factors Involved in Transport
Cellular Component
Molecular Function
Biological Process
KEGG
Reactome
- R-hsa-9694614 attachment and entry
- R-hsa-9772572 early sars cov 2 infection events
- R-hsa-9733458 induction of cell cell fusion
- R-hsa-5663205 infectious disease
- R-hsa-9772573 late sars cov 2 infection events
- R-hsa-9678108 sars cov 1 infection
- R-hsa-9694516 sars cov 2 infection
- R-hsa-9679506 sars cov infections
- R-hsa-9824446 viral infection pathways
Canonical Pathways
M278 Pid rac1 pathway
Mediation Categories
Clinical-translation mediationMetabolism mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
29 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | No | Yes | Yes | No | No |
| extracellular | extracellular | OmniPath | No | No | Yes | No | No |
| intracellular | intracellular | LOCATE | No | No | Yes | No | No |
| intracellular | intracellular | ComPPI | No | No | Yes | No | No |
| intracellular | intracellular | GO_Intercell | No | No | Yes | No | No |
| intracellular | intracellular | OmniPath | No | No | Yes | No | No |
| scavenger_receptor_cysteine_rich | cell_surface_enzyme | OmniPath | Yes | No | Yes | No | No |
| serine_protease | cell_surface_peptidase | OmniPath | Yes | No | Yes | No | No |
| cell_surface_enzyme | cell_surface_enzyme | OmniPath | Yes | No | Yes | No | No |
| cell_surface_peptidase | cell_surface_peptidase | OmniPath | Yes | No | Yes | No | No |
Page 1 of 3Next
Regulatory Interaction Network
0 records.
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass spectrometry | 1 | 30865381 |
Sequence, Structure & Domains
Sequences
Length
492
Mass
53,859
Sequence
MALNSGSPPAIGPYYENHGYQPENPYPAQPTVVPTVYEVHPAQYYPSPVPQYAPRVLTQASNPVVCTQPKSPSGTVCTSKTKKALCITLTLGTFLVGAALAAGLLWKFMGSKCSNSGIECDSSGTCINPSNWCDGVSHCPGGEDENRCVRLYGPNFILQVYSSQRKSWHPVCQDDWNENYGRAACRDMGYKNNFYSSQGIVDDSGSTSFMKLNTSAGNVDIYKKLYHSDACSSKAVVSLRCIACGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEKPLNNPWHWTAFAGILRQSFMFYGAGYQVEKVISHPNYDSKTKNNDIALMKLQKPLTFNDLVKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEVLNAAKVLLIETQRCNSRYVYDNLITPAMICAGFLQGNVDSCQGDSGGPLVTSKNNIWWLIGDTSWGSGCAKAYRPGVYGNVMVFTDWIYRQMRADG
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O15393-1; Sequence=Displayed; Name=2; IsoId=O15393-2; Sequence=VSP_045083
Alternative Sequence
1; M -> MPPAPPGGESGCEERGAAGHIEHSRYLSLLDAVDNSKM (in isoform 2)
3D Structural Models
Turn
153..156; 163..166; 188..192; 264..266; 300..303; 322..324; 339..342; 413..418; 438..442
Helix
114..116; 129..131; 143..145; 178..187; 221..224; 295..298; 305..307; 317..319; 407..410; 477..490
Beta Strand
117..119; 122..124; 134..136; 139..141; 149..152; 157..162; 167..172; 196..200; 210..212; 214..216; 225..227; 232..234; 236..240; 256..259; 270..275; 278..293; 309..313; 325..333; 347..353; 358..360; 378..384; 386..390; 398..405; 424..428; 430..432; 433..435; 444..449; 452..461; 463..466; 472..476
3D Structure
Electron microscopy (14); X-ray crystallography (16)
Domain & Motif Annotations
Domain (FT)
118..148; LDL-receptor class A; 149..242; SRCR; 256..492; Peptidase S1
Region
340..470; HKU1-CoV S protein-binding
Protein Families
Peptidase S1 family
Sequence Similarities
Belongs to the peptidase S1 family.
Clinical Relevance
Disease Involvement
Cancer-related genes
Biomarker
Phase 2; Investigative
Drug Targets
Literature-reported target
Interaction Protein
ENSG00000130234
Interaction Count
1
Interaction Dataset
intact_biogrid