Protein detail
COPT2
Protein SLC31A2 (Copper transporter 2) (hCTR2) (Solute carrier family 31 member 2)
Protein symbol COPT2 | UniProt ID | EVMP score 0.50 |
Frequency 4 | Transmembrane count 3 | Protein classification Predicted membrane proteinsTransporters |
Basic Information
Protein Names
Protein SLC31A2 (Copper transporter 2) (hCTR2) (Solute carrier family 31 member 2)
Protein Class
Predicted membrane proteinsTransporters
Protein Function
Transporters:Transporter channels and pores
Transmembrane
23..43; Helical; 94..114; Helical; 120..140; Helical
Transmembrane Count
3
Ensembl
Entrez Gene Symbol
Gene Synonym
COPT2CTR2hCTR2
Gene Description
Solute carrier family 31 member 2
Chromosome
9
Position
113150976-113164140
Frequency
4
EVMP Score
0.50
Fluorescence & Localization
Tissue SpecificintestineCell SpecificMyonucleiSingle-Nuclei Brain Specificcentral nervous system macrophageBlood Cell SpecificbasophilBlood Lineage Specificgranulocytes
Function & Pathway
Protein Function
Transporters:Transporter channels and pores
Cellular Component
Molecular Function
Biological Process
Canonical Pathways
- M240 Pid syndecan 2 pathway
- M94 Pid fas pathway
- M12 Pid rhoa pathway
Mediation Categories
Fusion and delivery mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
13 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | No | Yes | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_topology | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_keyword | No | No | No | No | No |
| transmembrane | transmembrane | LOCATE | No | No | No | No | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | No | No | No |
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Regulatory Interaction Network
0 records.
Protein Complex Composition
0 records.
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Western BlottingMass SpectrometryFlow Cytometry | 1 | 38207106 |
Sequence, Structure & Domains
Sequences
Length
143
Mass
15,681
Sequence
MAMHFIFSDTAVLLFDFWSVHSPAGMALSVLVLLLLAVLYEGIKVGKAKLLNQVLVNLPTSISQQTIAETDGDSAGSDSFPVGRTHHRWYLCHFGQSLIHVIQVVIGYFIMLAVMSYNTWIFLGVVLGSAVGYYLAYPLLSTA
3D Structural Models
Domain & Motif Annotations
Domain (CC)
The N-terminal domain may be involved in Cu(2+) acquisition from potential degradation products of proteins in the lysosome.
Protein Families
- Copper transporter (Ctr) (TC 1.A.56) family
- SLC31A subfamily
Sequence Similarities
Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.