Protein detail
MRP3
ATP-binding cassette sub-family C member 3 (EC 7.6.2.-) (EC 7.6.2.2) (EC 7.6.2.3) (Canalicular multispecific organic anion transporter 2) (Multi-specific organic anion transporter D) (MOAT-D) (Multidrug resistance-associated protein 3)
Entry name MRP3 | UniProt ID | EVMP confidence score 0.53 |
Supporting publications (n) 1 | Transmembrane count 17 | Protein classification Cancer-related genesEnzymesMetabolic proteinsPredicted intracellular proteinsPredicted membrane proteinsTransporters |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
ATP-binding cassette sub-family C member 3 (EC 7.6.2.-) (EC 7.6.2.2) (EC 7.6.2.3) (Canalicular multispecific organic anion transporter 2) (Multi-specific organic anion transporter D) (MOAT-D) (Multidrug resistance-associated protein 3)
Protein Class (6)
Cancer-related genesEnzymesMetabolic proteinsPredicted intracellular proteinsPredicted membrane proteinsTransporters
Protein Function (5)
- Predicted intracellular proteins
- Enzymes
- Cancer-related genes:Candidate cancer biomarkers
- ENZYME proteins
- Transporters:Primary Active Transporters
Transmembrane
33..53; Helical; Name=1; 74..94; Helical; Name=2; 100..120; Helical; Name=3; 133..153; Helical; Name=4; 172..192; Helical; Name=5; 303..323; Helical; Name=6; 350..370; Helical; Name=7; 427..447; Helical; Name=8; 451..471; Helical; Name=9; 534..554; Helical; Name=10; 577..597; Helical; Name=11; 964..984; Helical; Name=12; 1022..1042; Helical; Name=13; 1086..1106; Helical; Name=14; 1108..1128; Helical; Name=15; 1200..1220; Helical; Name=16; 1223..1243; Helical; Name=17
Transmembrane Count
17
Ensembl
Entrez Gene Symbol
Gene Synonym (5)
cMOAT2EST90757MLP2MOAT-DMRP3
Gene Description
ATP binding cassette subfamily C member 3
Chromosome
17
Position
50634777-50692253
Supporting publications (n)
1
EVMP confidence score
0.53
Fluorescence & Localization
Tissue SpecificbrainCell SpecificKupffer cells
Function & Pathway
Protein Function (5)
- Predicted intracellular proteins
- Enzymes
- Cancer-related genes:Candidate cancer biomarkers
- ENZYME proteins
- Transporters:Primary Active Transporters
Cellular Component (4)
Molecular Function (11)
- GO:0005524 ATP binding
- GO:0008559 ABC-type xenobiotic transporter activity
- GO:0015164 glucuronoside transmembrane transporter activity
- GO:0015431 ABC-type glutathione S-conjugate transporter activity
- GO:0015432 ABC-type bile acid transporter activity
- GO:0016887 ATP hydrolysis activity
- GO:0042626 ATPase-coupled transmembrane transporter activity
- GO:0042910 xenobiotic transmembrane transporter activity
- GO:0043225 ATPase-coupled inorganic anion transmembrane transporter activity
- GO:0071714 icosanoid transmembrane transporter activity
Page 1 of 2
Biological Process (3)
KEGG (4)
Reactome (14)
- R-hsa-382556 abc family proteins mediated transport
- R-hsa-9749641 aspirin adme
- R-hsa-194068 bile acid and bile salt metabolism
- R-hsa-8953897 cellular responses to stimuli
- R-hsa-9711123 cellular response to chemical stress
- R-hsa-9748784 drug adme
- R-hsa-9755511 keap1 nfe2l2 pathway
- R-hsa-556833 metabolism of lipids
- R-hsa-8957322 metabolism of steroids
- R-hsa-9818032 nfe2l2 regulating mdr associated enzymes
Page 1 of 2
Canonical Pathways (2)
- M211 Pid hedgehog 2pathway
- M219 Pid hedgehog gli pathway
Mediation Categories (3)
Clinical-translation mediationFusion and delivery mediationMetabolism mediation
Relations & Evidence31
Enzyme-Mediated Modification (1)
1 record.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| ABCC3 | EGF | P01133 | S | 911 | phosphorylation | BEL-Large-Corpus_ProtMapperProtMapper | ProtMapper:17081983 |
Ligand-Receptor Signaling (27)
27 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| active | transporter | Surfaceome | Yes | ||||
| transporter | transporter | OmniPath | Yes | ||||
| transmembrane | transmembrane | UniProt_location | |||||
| transmembrane | transmembrane | UniProt_topology | |||||
| transmembrane | transmembrane | UniProt_keyword | |||||
| transmembrane | transmembrane | TopDB | |||||
| transmembrane | transmembrane | LOCATE | |||||
| transmembrane | transmembrane | Ramilowski_location | |||||
| transmembrane | transmembrane | OmniPath | |||||
| plasma_membrane | plasma_membrane | UniProt_location |
Protein Complex Composition (2)
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometry | 1 | 25471207 |
Sequence, Structure & Domains
Sequences
Length
1,527
Mass
169,343
Sequence
MDALCGSGELGSKFWDSNLSVHTENPDLTPCFQNSLLAWVPCIYLWVALPCYLLYLRHHCRGYIILSHLSKLKMVLGVLLWCVSWADLFYSFHGLVHGRAPAPVFFVTPLVVGVTMLLATLLIQYERLQGVQSSGVLIIFWFLCVVCAIVPFRSKILLAKAEGEISDPFRFTTFYIHFALVLSALILACFREKPPFFSAKNVDPNPYPETSAGFLSRLFFWWFTKMAIYGYRHPLEEKDLWSLKEEDRSQMVVQQLLEAWRKQEKQTARHKASAAPGKNASGEDEVLLGARPRPRKPSFLKALLATFGSSFLISACFKLIQDLLSFINPQLLSILIRFISNPMAPSWWGFLVAGLMFLCSMMQSLILQHYYHYIFVTGVKFRTGIMGVIYRKALVITNSVKRASTVGEIVNLMSVDAQRFMDLAPFLNLLWSAPLQIILAIYFLWQNLGPSVLAGVAFMVLLIPLNGAVAVKMRAFQVKQMKLKDSRIKLMSEILNGIKVLKLYAWEPSFLKQVEGIRQGELQLLRTAAYLHTTTTFTWMCSPFLVTLITLWVYVYVDPNNVLDAEKAFVSVSLFNILRLPLNMLPQLISNLTQASVSLKRIQQFLSQEELDPQSVERKTISPGYAITIHSGTFTWAQDLPPTLHSLDIQVPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGKVHMKGSVAYVPQQAWIQNCTLQENVLFGKALNPKRYQQTLEACALLADLEMLPGGDQTEIGEKGINLSGGQRQRVSLARAVYSDADIFLLDDPLSAVDSHVAKHIFDHVIGPEGVLAGKTRVLVTHGISFLPQTDFIIVLADGQVSEMGPYPALLQRNGSFANFLCNYAPDEDQGHLEDSWTALEGAEDKEALLIEDTLSNHTDLTDNDPVTYVVQKQFMRQLSALSSDGEGQGRPVPRRHLGPSEKVQVTEAKADGALTQEEKAAIGTVELSVFWDYAKAVGLCTTLAICLLYVGQSAAAIGANVWLSAWTNDAMADSRQNNTSLRLGVYAALGILQGFLVMLAAMAMAAGGIQAARVLHQALLHNKIRSPQSFFDTTPSGRILNCFSKDIYVVDEVLAPVILMLLNSFFNAISTLVVIMASTPLFTVVILPLAVLYTLVQRFYAATSRQLKRLESVSRSPIYSHFSETVTGASVIRAYNRSRDFEIISDTKVDANQRSCYPYIISNRWLSIGVEFVGNCVVLFAALFAVIGRSSLNPGLVGLSVSYSLQVTFALNWMIRMMSDLESNIVAVERVKEYSKTETEAPWVVEGSRPPEGWPPRGEVEFRNYSVRYRPGLDLVLRDLSLHVHGGEKVGIVGRTGAGKSSMTLCLFRILEAAKGEIRIDGLNVADIGLHDLRSQLTIIPQDPILFSGTLRMNLDPFGSYSEEDIWWALELSHLHTFVSSQPAGLDFQCSEGGENLSVGQRQLVCLARALLRKSRILVLDEATAAIDLETDNLIQATIRTQFDTCTVLTIAHRLNTIMDYTRVLVLDKGVVAEFDSPANLIAARGIFYGMARDAGLA
Alternative Products
Event=Alternative splicing; Named isoforms=5; Comment=Additional isoforms seem to exist.; Name=1; Synonyms=MRP3; IsoId=O15438-1; Sequence=Displayed; Name=2; Synonyms=MRP3A; IsoId=O15438-2; Sequence=VSP_000042; Name=3; Synonyms=MRP3B; IsoId=O15438-3; Sequence=VSP_000040, VSP_000041; Name=4; Synonyms=MRP3S1; IsoId=O15438-4; Sequence=VSP_043864; Name=5; IsoId=O15438-5; Sequence=VSP_039041, VSP_039042
Alternative Sequence
1; M -> MPACTVKESPNCKRNFCKADHIVNTSGGSNLERVGKQKTIQKGQFSQRSVCT (in isoform 4); 226..510; MAIYGYRHPLEEKDLWSLKEEDRSQMVVQQLLEAWRKQEKQTARHKASAAPGKNASGEDEVLLGARPRPRKPSFLKALLATFGSSFLISACFKLIQDLLSFINPQLLSILIRFISNPMAPSWWGFLVAGLMFLCSMMQSLILQHYYHYIFVTGVKFRTGIMGVIYRKALVITNSVKRASTVGEIVNLMSVDAQRFMDLAPFLNLLWSAPLQIILAIYFLWQNLGPSVLAGVAFMVLLIPLNGAVAVKMRAFQVKQMKLKDSRIKLMSEILNGIKVLKLYAWEPSF -> LLNPDPLRGCLPGFTSPQDGHLWLPASPGGEGPLVPKGRGQIPDGGAAAAGGMEEAGKADGTTQGFSSTWEKCLRRGRGAAGCPAQAPEALLPEGPAGHLRLQLPHQCLLQAYPGPALLHQSTAAQHPDQVYLQPHGPLLVGLPGGWADVPVLHDAVADLTTLLPLHLCDWGEVSYWDHGCHLQEGSGYHQLSQTCVHCGGNCQPHVSGCPALHGPCPLPQSAVVSTPADHPGDLLPLAEPRSLCPGWSRFHGLADSTQRSCGREDARLPGKANEIEGLAHQADE (in isoform 3); 511..1527; Missing (in isoform 3); 547..572; TLITLWVYVYVDPNNVLDAEKAFVSV -> RLGTGLGPCLQGSGCPGMARAHWTLP (in isoform 5); 573..1527; Missing (in isoform 5); 1194..1527; WLSIGVEFVGNCVVLFAALFAVIGRSSLNPGLVGLSVSYSLQVTFALNWMIRMMSDLESNIVAVERVKEYSKTETEAPWVVEGSRPPEGWPPRGEVEFRNYSVRYRPGLDLVLRDLSLHVHGGEKVGIVGRTGAGKSSMTLCLFRILEAAKGEIRIDGLNVADIGLHDLRSQLTIIPQDPILFSGTLRMNLDPFGSYSEEDIWWALELSHLHTFVSSQPAGLDFQCSEGGENLSVGQRQLVCLARALLRKSRILVLDEATAAIDLETDNLIQATIRTQFDTCTVLTIAHRLNTIMDYTRVLVLDKGVVAEFDSPANLIAARGIFYGMARDAGLA -> SEAASLAPCSSRNSQQALWCSGSLSLLSPKQKTGPALPLPHFLLI (in isoform 2)
3D Structural Models
Turn
93..97; 111..114; 128..130; 153..155; 159..162; 208..211; 237..239; 249..252; 308..310; 323..325; 359..365; 375..383; 386..389; 415..418; 420..422; 429..431; 467..469; 526..528; 533..535; 737..740; 777..780; 968..970; 1021..1026; 1095..1098; 1153..1157; 1217..1220; 1334..1338; 1380..1384; 1472..1474
Helix
35..48; 50..53; 55..57; 68..71; 75..92; 103..105; 108..110; 115..127; 136..152; 156..158; 168..173; 176..188; 215..218; 224..232; 245..247; 253..264; 300..307; 314..322; 327..339; 346..358; 367..374; 390..393; 398..402; 411..414; 423..426; 432..448; 449..452; 453..461; 464..466; 475..496; 499..503; 507..525; 537..540; 542..556; 565..582; 585..594; 597..606; 667..675; 705..710; 717..726; 732..735; 753..767; 783..792; 835..840; 844..848; 956..966; 972..975; 978..995; 1008..1019; 1027..1052; 1057..1062; 1065..1071; 1074..1081; 1083..1094; 1099..1107; 1109..1114; 1117..1152; 1158..1163; 1167..1185; 1193..1199; 1202..1216; 1225..1231; 1234..1236; 1238..1253; 1255..1263; 1329..1333; 1354..1356; 1359..1362; 1363..1365; 1392..1401; 1405..1410; 1414..1416; 1428..1442; 1458..1471; 1484..1487; 1507..1512; 1516..1522
Beta Strand
311..313; 342..344; 470..472; 529..532; 616..619; 625..637; 643..652; 656..660; 678..682; 685..687; 691..694; 702..704; 711..713; 741..749; 770..775; 801..808; 819..825; 828..833; 1275..1277; 1289..1296; 1305..1313; 1318..1322; 1344..1351; 1366..1369; 1377..1379; 1411..1413; 1423..1426; 1445..1450; 1454..1456; 1475..1480; 1490..1497; 1500..1505
3D Structure
Electron microscopy (4)
Domain & Motif Annotations
Domain (FT)
311..594; ABC transmembrane type-1 1; 629..851; ABC transporter 1; 971..1252; ABC transmembrane type-1 2; 1291..1523; ABC transporter 2
Region
910..932; Disordered
Protein Families (3)
- ABC transporter superfamily
- ABCC family
- Conjugate transporter (TC 3.A.1.208) subfamily
Sequence Similarities
Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
Clinical Relevance
Disease Involvement
Cancer-related genes
Drugs (29)
CEFMETAZOLECEFTRIAXONENEVIRAPINECEFUROXIME AXETILNULLEMTRICITABINEPACLITAXELPAREGORICCEPHALEXIN ANHYDROUSRIMONABANTLAMIVUDINETENOFOVIRDOXORUBICIN HYDROCHLORIDEETOPOSIDECEFOXITIN SODIUMBUSULFANEFAVIRENZABACAVIRVINCRISTINECYTARABINEMONOMETHYL AURISTATIN ECEPHRADINECEFACLOR ANHYDROUSDELAVIRDINECEFOPERAZONECEFAMANDOLEMORPHINE GLUCURONIDEETRAVIRINECYCLOPHOSPHAMIDE ANHYDROUS
Supporting Publications1
| PMID | Title | Related sentences |
|---|---|---|
| 37633233 | Mechanism of M2 type macrophage-derived extracellular vesicles regulating PD-L1 expression via the MISP/IQGAP1 axis in hepatocellular carcinoma immunotherapy resistance. | Mechanism of M2 type macrophage-derived extracellular vesicles regulating PD-L1 expression via the MISP/IQGAP1 axis in hepatocellular carcinoma immunotherapy resistance. |