Protein detail
MRP4
ATP-binding cassette sub-family C member 4 (EC 7.6.2.-) (EC 7.6.2.2) (EC 7.6.2.3) (MRP/cMOAT-related ABC transporter) (Multi-specific organic anion transporter B) (MOAT-B) (Multidrug resistance-associated protein 4)
Entry name MRP4 | UniProt ID | EVMP confidence score 0.72 |
Supporting publications (n) 13 | Transmembrane count 12 | Protein classification EnzymesMetabolic proteinsPlasma proteinsPredicted membrane proteinsTransporters |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information13
Protein Names
ATP-binding cassette sub-family C member 4 (EC 7.6.2.-) (EC 7.6.2.2) (EC 7.6.2.3) (MRP/cMOAT-related ABC transporter) (Multi-specific organic anion transporter B) (MOAT-B) (Multidrug resistance-associated protein 4)
Protein Class (5)
EnzymesMetabolic proteinsPlasma proteinsPredicted membrane proteinsTransporters
Protein Function (3)
- Enzymes
- ENZYME proteins
- Transporters:Primary Active Transporters
Transmembrane
89..131; Helical; Name=1; 137..176; Helical; Name=2; 211..244; Helical; Name=3; 247..274; Helical; Name=4; 319..352; Helical; Name=5; 357..390; Helical; Name=6; 720..755; Helical; Name=7; 769..803; Helical; Name=8; 840..871; Helical; Name=9; 874..892; Helical; Name=10; 950..984; Helical; Name=11; 985..1014; Helical; Name=12
Transmembrane Count
12
Ensembl
Entrez Gene Symbol
Gene Synonym (4)
EST170205MOAT-BMOATBMRP4
Gene Description
ATP binding cassette subfamily C member 4
Chromosome
13
Position
95019835-95301475
Supporting publications (n)
13
EVMP confidence score
0.72
Fluorescence & Localization5
Tissue Specificlymphoid tissueCell SpecificInnate lymphoid cellsSingle-Nuclei Brain SpecificleukocyteBlood Cell SpecificT-regBlood Lineage SpecificT-cells
Function & Pathway8
Protein Function (3)
- Enzymes
- ENZYME proteins
- Transporters:Primary Active Transporters
Cellular Component (8)
Molecular Function (17)
- GO:0001409 guanine nucleotide transmembrane transporter activity
- GO:0005515 protein binding
- GO:0005524 ATP binding
- GO:0008559 ABC-type xenobiotic transporter activity
- GO:0015132 prostaglandin transmembrane transporter activity
- GO:0015143 urate transmembrane transporter activity
- GO:0015216 purine nucleotide transmembrane transporter activity
- GO:0015431 ABC-type glutathione S-conjugate transporter activity
- GO:0015432 ABC-type bile acid transporter activity
- GO:0015562 efflux transmembrane transporter activity
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Biological Process (3)
KEGG (5)
Reactome (8)
- R-hsa-382556 abc family proteins mediated transport
- R-hsa-9748787 azathioprine adme
- R-hsa-9748784 drug adme
- R-hsa-109582 hemostasis
- R-hsa-9753281 paracetamol adme
- R-hsa-76002 platelet activation signaling and aggregation
- R-hsa-76005 response to elevated platelet cytosolic ca2
- R-hsa-382551 transport of small molecules
Canonical Pathways (3)
- M169 Pid integrin2 pathway
- M72 Pid nectin pathway
- M53 Pid integrin3 pathway
Mediation Categories (3)
Clinical-translation mediationFusion and delivery mediationImmune mediation
Relations & Evidence30
Ligand-Receptor Signaling (27)
27 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | No | Yes | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| transporter | transporter | Surfaceome | No | Yes | No | No | No |
| abcc | transporter | HGNC | No | Yes | No | No | No |
| transporter | transporter | HGNC | No | Yes | No | No | No |
| abc | transporter | DGIdb | No | Yes | No | No | No |
| transporter | transporter | DGIdb | No | Yes | No | No | No |
| abcc | transporter | Almen2009 | No | Yes | No | No | No |
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Regulatory Interaction Network (1)
1 record.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| MRP4 | O15439 | COMPLEX:O95295_P78537_Q6QNY0_Q6QNY1_Q8TDH9_Q96EV8_Q9NUP1_Q9UL45 | Yes | Yes | No | SIGNOR | SIGNOR:23805129 |
Protein Complex Composition (1)
Sequence, Structure & Domains16
Sequences
Length
1,325
Mass
149,527
Sequence
MLPVYQEVKPNPLQDANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGEELQGFWDKEVLRAENDAQKPSLTRAIIKCYWKSYLVLGIFTLIEESAKVIQPIFLGKIINYFENYDPMDSVALNTAYAYATVLTFCTLILAILHHLYFYHVQCAGMRLRVAMCHMIYRKALRLSNMAMGKTTTGQIVNLLSNDVNKFDQVTVFLHFLWAGPLQAIAVTALLWMEIGISCLAGMAVLIILLPLQSCFGKLFSSLRSKTATFTDARIRTMNEVITGIRIIKMYAWEKSFSNLITNLRKKEISKILRSSCLRGMNLASFFSASKIIVFVTFTTYVLLGSVITASRVFVAVTLYGAVRLTVTLFFPSAIERVSEAIVSIRRIQTFLLLDEISQRNRQLPSDGKKMVHVQDFTAFWDKASETPTLQGLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHGRIAYVSQQPWVFSGTLRSNILFGKKYEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELCICQILHEKITILVTHQLQYLKAASQILILKDGKMVQKGTYTEFLKSGIDFGSLLKKDNEESEQPPVPGTPTLRNRTFSESSVWSQQSSRPSLKDGALESQDTENVPVTLSEENRSEGKVGFQAYKNYFRAGAHWIVFIFLILLNTAAQVAYVLQDWWLSYWANKQSMLNVTVNGGGNVTEKLDLNWYLGIYSGLTVATVLFGIARSLLVFYVLVNSSQTLHNKMFESILKAPVLFFDRNPIGRILNRFSKDIGHLDDLLPLTFLDFIQTLLQVVGVVSVAVAVIPWIAIPLVPLGIIFIFLRRYFLETSRDVKRLESTTRSPVFSHLSSSLQGLWTIRAYKAEERCQELFDAHQDLHSEAWFLFLTTSRWFAVRLDAICAMFVIIVAFGSLILAKTLDAGQVGLALSYALTLMGMFQWCVRQSAEVENMMISVERVIEYTDLEKEAPWEYQKRPPPAWPHEGVIIFDNVNFMYSPGGPLVLKHLTALIKSQEKVGIVGRTGAGKSSLISALFRLSEPEGKIWIDKILTTEIGLHDLRKKMSIIPQEPVLFTGTMRKNLDPFNEHTDEELWNALQEVQLKETIEDLPGKMDTELAESGSNFSVGQRQLVCLARAILRKNQILIIDEATANVDPRTDELIQKKIREKFAHCTVLTIAHRLNTIIDSDKIMVLDSGRLKEYDEPYVLLQNKESLFYKMVQQLGKAEAAALTETAKQVYFKRNYPHIGHTDHMVTNTSNGQPSTLTIFETAL
Alternative Products
Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=O15439-1; Sequence=Displayed; Name=2; IsoId=O15439-2; Sequence=VSP_035426; Name=3; IsoId=O15439-3; Sequence=VSP_043283, VSP_043284; Name=4; IsoId=O15439-4; Sequence=VSP_057413, VSP_043283, VSP_043284
Alternative Sequence
103..177; Missing (in isoform 4); 679..725; Missing (in isoform 2); 846..859; TLLQVVGVVSVAVA -> RWDLAVLSWLVSNS (in isoform 3 and isoform 4); 860..1325; Missing (in isoform 3 and isoform 4)
3D Structural Models
Turn
12..15; 457..459; 561..564; 577..580; 622..624; 627..630; 751..754; 917..919; 1078..1080; 1298..1300
Helix
18..23; 25..27; 28..36; 41..43; 49..51; 53..74; 80..121; 128..150; 152..178; 183..188; 191..199; 202..204; 205..211; 214..233; 236..281; 283..289; 292..341; 348..390; 446..448; 451..456; 489..494; 501..510; 514..519; 523..525; 530..532; 537..550; 567..576; 581..583; 595..599; 617..619; 698..706; 711..750; 761..806; 810..815; 818..860; 862..864; 865..895; 898..909; 911..916; 920..969; 971..973; 976..1017; 1081..1089; 1105..1107; 1110..1114; 1131..1135; 1143..1152; 1156..1160; 1165..1167; 1179..1193; 1209..1221; 1236..1239; 1258..1263; 1268..1276; 1278..1296
Beta Strand
409..417; 423..425; 427..435; 440..444; 465..473; 475..478; 486..488; 520..522; 527..529; 533..535; 554..560; 584..590; 600..609; 611..613; 693..695; 1036..1038; 1042..1047; 1059..1064; 1071..1073; 1099..1102; 1117..1120; 1128..1130; 1162..1164; 1174..1177; 1196..1202; 1204..1206; 1224..1233; 1241..1244; 1252..1256; 1265..1267
3D Structure
Electron microscopy (21)
Domain & Motif Annotations
Compositional Bias
657..667; Low complexity
Motif
1322..1325; PDZ-binding
Domain (CC)
The two ABC transmembrane type-1 domains are essential for substrates binding and transport (PubMed:38886124, PubMed:40138312). The two ABC transporter domains, also known as nucleotide-binding domains, are essential for ATP binding and hydrolysis (PubMed:38886124, PubMed:40138312).
Domain (FT)
93..377; ABC transmembrane type-1 1; 410..633; ABC transporter 1; 711..1005; ABC transmembrane type-1 2; 1041..1274; ABC transporter 2
Region
657..688; Disordered
Protein Families (3)
- ABC transporter superfamily
- ABCC family
- Conjugate transporter (TC 3.A.1.208) subfamily
Sequence Similarities
Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
Clinical Relevance6
Drug Targets
Literature-reported target
Drugs (32)
RIMONABANTIMATINIBCEFMETAZOLEFLUOROURACILCEPHALEXIN ANHYDROUSCEFUROXIME AXETILMETHOTREXATECEFTRIAXONELAMIVUDINECEFAMANDOLEZIDOVUDINEAZATHIOPRINEMISOPROSTOLTHIOGUANINEGANCICLOVIRNULLIRINOTECAN HYDROCHLORIDEINDINAVIRGLUCARPIDASEANTIVIRAL AGENTCISPLATINFUROSEMIDECEPHRADINECEFACLOR ANHYDROUSCEFOPERAZONEADEFOVIR DIPIVOXILDOXORUBICIN HYDROCHLORIDECYTARABINEEFAVIRENZCEFOXITIN SODIUMADEFOVIRLEUCOVORIN CALCIUM
Antibody
Interaction Protein
ENSG00000130830
Interaction Count
1
Interaction Dataset
intact_biogrid
Supporting Publications13
| PMID | Title | Abstract |
|---|---|---|
| 30550287 | Label-Free Proteomic Analysis of Exosomes Secreted from THP-1-Derived Macrophages Treated with IFN-α Identifies Antiviral Proteins Enriched in Exosomes. | No abstract available |
| 31508500 | Proteomic profiling of extracellular vesicles allows for human breast cancer subtyping. | No abstract available |
| 37686366 | Identification of a Non-Invasive Urinary Exosomal Biomarker for Diabetic Nephropathy Using Data-Independent Acquisition Proteomics. | No abstract available |
| 37922300 | Proteomic profiling of urinary extracellular vesicles differentiates breast cancer patients from healthy women. | No abstract available |
| 38225453 | Deep proteomic analysis of obstetric antiphospholipid syndrome by DIA-MS of extracellular vesicle enriched fractions. | No abstract available |
| 38490958 | Proteomic analysis of ascitic extracellular vesicles describes tumour microenvironment and predicts patient survival in ovarian cancer. | No abstract available |
| 39290459 | Urinary extracellular vesicles as a monitoring tool for renal damage in patients not meeting criteria for chronic kidney disease. | No abstract available |
| 39443544 | Profiling of urinary extracellular vesicle protein signatures from patients with cribriform and intraductal prostate carcinoma in a cross-sectional study. | No abstract available |
| 39835386 | Comparison of nanoLC-MALDI-MS/MS with nanoLC-TIMS-MS/MS in the proteomic analysis of extracellular vesicles of bronchoalveolar lavage fluid. | No abstract available |
| 40091455 | Potential Role of Menstrual Fluid-Derived Small Extracellular Vesicle Proteins in Endometriosis Pathogenesiss. | No abstract available |
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