Protein detail
MRP5
ATP-binding cassette sub-family C member 5 (EC 7.6.2.-) (EC 7.6.2.2) (Multi-specific organic anion transporter C) (MOAT-C) (Multidrug resistance-associated protein 5) (SMRP) (pABC11)
Entry name MRP5 | UniProt ID | EVMP confidence score 0.53 |
Supporting publications (n) 3 | Transmembrane count 13 | Protein classification Cancer-related genesEnzymesMetabolic proteinsPredicted intracellular proteinsPredicted membrane proteinsTransporters |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
ATP-binding cassette sub-family C member 5 (EC 7.6.2.-) (EC 7.6.2.2) (Multi-specific organic anion transporter C) (MOAT-C) (Multidrug resistance-associated protein 5) (SMRP) (pABC11)
Protein Class (6)
Cancer-related genesEnzymesMetabolic proteinsPredicted intracellular proteinsPredicted membrane proteinsTransporters
Protein Function (5)
- Predicted intracellular proteins
- Enzymes
- Cancer-related genes:Candidate cancer biomarkers
- ENZYME proteins
- Transporters:Primary Active Transporters
Transmembrane
179..199; Helical; 219..239; Helical; 296..316; Helical; 317..337; Helical; 400..420; Helical; 434..454; Helical; 608..628; Helical; 848..868; Helical; 917..937; Helical; 997..1017; Helical; 1018..1038; Helical; 1104..1124; Helical; 1127..1147; Helical
Transmembrane Count
13
Ensembl
Entrez Gene Symbol
Gene Synonym (4)
EST277145MOAT-CMRP5SMRP
Gene Description
ATP binding cassette subfamily C member 5
Chromosome
3
Position
183919934-184017939
Supporting publications (n)
3
EVMP confidence score
0.53
Function & Pathway
Protein Function (5)
- Predicted intracellular proteins
- Enzymes
- Cancer-related genes:Candidate cancer biomarkers
- ENZYME proteins
- Transporters:Primary Active Transporters
Cellular Component (6)
Molecular Function (13)
- GO:0005524 ATP binding
- GO:0008514 organic anion transmembrane transporter activity
- GO:0008559 ABC-type xenobiotic transporter activity
- GO:0015216 purine nucleotide transmembrane transporter activity
- GO:0015232 heme transmembrane transporter activity
- GO:0015562 efflux transmembrane transporter activity
- GO:0016887 ATP hydrolysis activity
- GO:0022884 macromolecule transmembrane transporter activity
- GO:0034634 glutathione transmembrane transporter activity
- GO:0042626 ATPase-coupled transmembrane transporter activity
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Biological Process (3)
KEGG (3)
Reactome (8)
- R-hsa-382556 abc family proteins mediated transport
- R-hsa-9748787 azathioprine adme
- R-hsa-9748784 drug adme
- R-hsa-1630316 glycosaminoglycan metabolism
- R-hsa-2142845 hyaluronan metabolism
- R-hsa-71387 metabolism of carbohydrates and carbohydrate derivatives
- R-hsa-9753281 paracetamol adme
- R-hsa-382551 transport of small molecules
Canonical Pathways
M238 Pid thrombin par1 pathway
Mediation Categories (3)
Clinical-translation mediationFusion and delivery mediationMetabolism mediation
Relations & Evidence32
Ligand-Receptor Signaling (30)
30 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | Yes | ||||
| extracellular | extracellular | OmniPath | |||||
| intracellular | intracellular | LOCATE | |||||
| intracellular | intracellular | ComPPI | |||||
| intracellular | intracellular | GO_Intercell | |||||
| intracellular | intracellular | UniProt_location | |||||
| intracellular | intracellular | OmniPath | |||||
| transporter | transporter | Surfaceome | Yes | ||||
| abcc | transporter | HGNC | Yes | ||||
| transporter | transporter | HGNC | Yes |
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Protein Complex Composition (1)
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion Chromatography | Mass spectrometry [LTQ-FT Ultra]Mass spectrometry | 26 | 3168598438937789399494903150850038225453398737263279541426775013258445992680191926884841282428433055028730608700337095104061999527312428309758943768636638490958341862432839651130760538313205914031161636332889 |
Sequence, Structure & Domains
Sequences
Length
1,437
Mass
160,660
Sequence
MKDIDIGKEYIIPSPGYRSVRERTSTSGTHRDREDSKFRRTRPLECQDALETAARAEGLSLDASMHSQLRILDEEHPKGKYHHGLSALKPIRTTSKHQHPVDNAGLFSCMTFSWLSSLARVAHKKGELSMEDVWSLSKHESSDVNCRRLERLWQEELNEVGPDAASLRRVVWIFCRTRLILSIVCLMITQLAGFSGPAFMVKHLLEYTQATESNLQYSLLLVLGLLLTEIVRSWSLALTWALNYRTGVRLRGAILTMAFKKILKLKNIKEKSLGELINICSNDGQRMFEAAAVGSLLAGGPVVAILGMIYNVIILGPTGFLGSAVFILFYPAMMFASRLTAYFRRKCVAATDERVQKMNEVLTYIKFIKMYAWVKAFSQSVQKIREEERRILEKAGYFQSITVGVAPIVVVIASVVTFSVHMTLGFDLTAAQAFTVVTVFNSMTFALKVTPFSVKSLSEASVAVDRFKSLFLMEEVHMIKNKPASPHIKIEMKNATLAWDSSHSSIQNSPKLTPKMKKDKRASRGKKEKVRQLQRTEHQAVLAEQKGHLLLDSDERPSPEEEEGKHIHLGHLRLQRTLHSIDLEIQEGKLVGICGSVGSGKTSLISAILGQMTLLEGSIAISGTFAYVAQQAWILNATLRDNILFGKEYDEERYNSVLNSCCLRPDLAILPSSDLTEIGERGANLSGGQRQRISLARALYSDRSIYILDDPLSALDAHVGNHIFNSAIRKHLKSKTVLFVTHQLQYLVDCDEVIFMKEGCITERGTHEELMNLNGDYATIFNNLLLGETPPVEINSKKETSGSQKKSQDKGPKTGSVKKEKAVKPEEGQLVQLEEKGQGSVPWSVYGVYIQAAGGPLAFLVIMALFMLNVGSTAFSTWWLSYWIKQGSGNTTVTRGNETSVSDSMKDNPHMQYYASIYALSMAVMLILKAIRGVVFVKGTLRASSRLHDELFRRILRSPMKFFDTTPTGRILNRFSKDMDEVDVRLPFQAEMFIQNVILVFFCVGMIAGVFPWFLVAVGPLVILFSVLHIVSRVLIRELKRLDNITQSPFLSHITSSIQGLATIHAYNKGQEFLHRYQELLDDNQAPFFLFTCAMRWLAVRLDLISIALITTTGLMIVLMHGQIPPAYAGLAISYAVQLTGLFQFTVRLASETEARFTSVERINHYIKTLSLEAPARIKNKAPSPDWPQEGEVTFENAEMRYRENLPLVLKKVSFTIKPKEKIGIVGRTGSGKSSLGMALFRLVELSGGCIKIDGVRISDIGLADLRSKLSIIPQEPVLFSGTVRSNLDPFNQYTEDQIWDALERTHMKECIAQLPLKLESEVMENGDNFSVGERQLLCIARALLRHCKILILDEATAAMDTETDLLIQETIREAFADCTMLTIAHRLHTVLGSDRIMVLAQGQVVEFDTPSVLLSNDSSRFYAMFAAAENKVAVKG
Alternative Products
Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=O15440-1; Sequence=Displayed; Name=2; Synonyms=SV1; IsoId=O15440-2; Sequence=VSP_043397, VSP_043402; Name=3; Synonyms=SV2; IsoId=O15440-3; Sequence=VSP_043398, VSP_043401, VSP_043402; Name=4; Synonyms=SV3; IsoId=O15440-4; Sequence=VSP_043399, VSP_043400, VSP_043402; Name=5; IsoId=O15440-5; Sequence=VSP_055354
Alternative Sequence
198..225; AFMVKHLLEYTQATESNLQYSLLLVLGL -> PSFGDCSISAEVCGNRLHCTAILLSCFT (in isoform 2); 198..212; AFMVKHLLEYTQATE -> LAWCCQDLDLGGVSL (in isoform 3); 198..208; AFMVKHLLEYT -> NFQDGCILRSE (in isoform 4); 209..225; Missing (in isoform 4); 213..225; Missing (in isoform 3); 226..1437; Missing (in isoform 2, isoform 3 and isoform 4); 1033..1075; Missing (in isoform 5)
3D Structural Models
Turn
56..58; 116..118; 130..132; 162..164; 370..372; 422..425; 444..449; 728..730; 746..749; 1052..1054; 1139..1142; 1164..1168; 1233..1237; 1316..1319; 1342..1347; 1361..1363; 1376..1378
Helix
49..55; 100..103; 107..111; 113..115; 119..125; 142..159; 167..209; 215..263; 268..270; 273..281; 283..293; 294..298; 300..309; 319..343; 348..363; 365..369; 375..399; 400..402; 406..421; 430..443; 450..471; 601..609; 641..644; 651..661; 664..669; 673..675; 687..701; 718..727; 731..733; 767..772; 776..786; 843..853; 856..886; 905..907; 911..957; 960..965; 968..976; 978..984; 986..1010; 1014..1031; 1034..1051; 1055..1059; 1062..1067; 1070..1119; 1126..1138; 1143..1163; 1238..1241; 1263..1266; 1267..1269; 1284..1288; 1296..1305; 1309..1313; 1325..1327; 1332..1341; 1364..1375; 1411..1416; 1421..1431
Beta Strand
97..99; 138..140; 210..212; 264..266; 312..315; 488..495; 497..499; 584..588; 590..594; 612..614; 615..617; 619..621; 625..628; 636..638; 645..647; 670..672; 704..708; 713..715; 734..738; 742..745; 753..757; 760..763; 892..894; 896..901; 1122..1124; 1188..1190; 1193..1200; 1209..1216; 1224..1226; 1248..1253; 1256..1261; 1271..1273; 1281..1283; 1349..1354; 1379..1384; 1388..1391; 1398..1401; 1404..1409
3D Structure
Electron microscopy (6)
Domain & Motif Annotations
Compositional Bias
19..41; Basic and acidic residues; 501..511; Polar residues; 514..529; Basic residues; 795..827; Basic and acidic residues
Domain (FT)
179..459; ABC transmembrane type-1 1; 562..783; ABC transporter 1; 859..1155; ABC transmembrane type-1 2; 1193..1427; ABC transporter 2
Region
15..41; Disordered; 501..538; Disordered; 794..827; Disordered
Protein Families (3)
- ABC transporter superfamily
- ABCC family
- Conjugate transporter (TC 3.A.1.208) subfamily
Sequence Similarities
Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
Clinical Relevance
Disease Involvement
Cancer-related genes
Drugs (10)
Supporting Publications3
| PMID | Title | Related sentences |
|---|---|---|
| 38113368 | In-Depth Proteome Profiling of Small Extracellular Vesicles Isolated from Cancer Cell Lines and Patient Serum. | No related sentences available |
| 38207106 | Proteomic, Metabolomic, and Fatty Acid Profiling of Small Extracellular Vesicles from Glioblastoma Stem-Like Cells and Their Role in Tumor Heterogeneity. | No related sentences available |
| 41307968 | Extracellular Vesicles Define Discrete Nano-Based Niches Within the Human Haematopoietic System. | No related sentences available |