Protein detail
SIA8E
Alpha-2,8-sialyltransferase 8E (EC 2.4.99.-) (Sialyltransferase 8E) (SIAT8-E) (Sialyltransferase St8Sia V) (ST8SiaV)
Entry name SIA8E | UniProt ID | EVMP confidence score 0.50 |
Supporting publications (n) 1 | Transmembrane count 1 | Protein classification Metabolic proteinsPredicted membrane proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information12
Protein Names
Alpha-2,8-sialyltransferase 8E (EC 2.4.99.-) (Sialyltransferase 8E) (SIAT8-E) (Sialyltransferase St8Sia V) (ST8SiaV)
Protein Class (2)
Metabolic proteinsPredicted membrane proteins
Transmembrane
18..38; Helical; Signal-anchor for type II membrane protein
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
SIAT8E
Gene Description
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5
Chromosome
18
Position
46667821-46759257
Supporting publications (n)
1
EVMP confidence score
0.50
Fluorescence & Localization5
Tissue Specificlymphoid tissueCell SpecificCardiomyocytesSingle-Nuclei Brain SpecificfibroblastBlood Cell Specificmemory B-cellBlood Lineage SpecificB-cells
Function & Pathway6
Cellular Component
Molecular Function (3)
Biological Process (3)
Reactome (9)
- R-hsa-446203 asparagine n linked glycosylation
- R-hsa-446193 biosynthesis of the n glycan precursor dolichol lipid linked oligosaccharide llo and transfer to a nascent protein
- R-hsa-9840309 glycosphingolipid biosynthesis
- R-hsa-1660662 glycosphingolipid metabolism
- R-hsa-556833 metabolism of lipids
- R-hsa-597592 post translational protein modification
- R-hsa-4085001 sialic acid metabolism
- R-hsa-428157 sphingolipid metabolism
- R-hsa-446219 synthesis of substrates in n glycan biosythesis
Mediation Categories
Metabolism mediation
Relations & Evidence17
Ligand-Receptor Signaling (16)
16 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_topology | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_keyword | No | No | No | No | No |
| transmembrane_predicted | transmembrane | OmniPath | No | No | No | No | No |
| transmembrane | transmembrane | LOCATE | No | No | No | No | No |
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Sequence, Structure & Domains7
Sequences
Length
376
Mass
43,895
Sequence
MRYADPSANRDLLGSRTLLFIFICAFALVTLLQQILYGRNYIKRYFEFYEGPFEYNSTRCLELRHEILEVKVLSMVKQSELFDRWKSLQMCKWAMNISEANQFKSTLSRCCNAPAFLFTTQKNTPLGTKLKYEVDTSGIYHINQEIFRMFPKDMPYYRSQFKKCAVVGNGGILKNSRCGREINSADFVFRCNLPPISEKYTMDVGVKTDVVTVNPSIITERFHKLEKWRRPFYRVLQVYENASVLLPAFYNTRNTDVSIRVKYVLDDFESPQAVYYFHPQYLVNVSRYWLSLGVRAKRISTGLILVTAALELCEEVHLFGFWAFPMNPSGLYITHHYYDNVKPRPGFHAMPSEIFNFLHLHSRGILRVHTGTCSCC
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O15466-1; Sequence=Displayed; Name=2; IsoId=O15466-2; Sequence=VSP_056664
Alternative Sequence
43; K -> KRGLQFGWQSGDQLTNWTGLFNVTDDPAVQSGSDSSS (in isoform 2)
Domain & Motif Annotations
Protein Families
Glycosyltransferase 29 family
Sequence Similarities
Belongs to the glycosyltransferase 29 family.
Supporting Publications1
| PMID | Title | Abstract |
|---|---|---|
| 28211531 | Proteomic analysis of urinary extracellular vesicles from high Gleason score prostate cancer. | No abstract available |