Protein detail
MEFV
Pyrin (Marenostrin)
Protein symbol MEFV | UniProt ID | EVMP score 0.38 |
Frequency 1 | Transmembrane count | Protein classification |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Pyrin (Marenostrin)
Protein Function
- Human disease related genes:Immune system diseases:Allergies and autoimmune diseases
- Disease related genes
- Human disease related genes:Immune system diseases:Other immune system diseases
- Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Frequency
1
EVMP Score
0.38
Fluorescence & Localization
Tissue SpecificbrainCell SpecificPodocytes
Function & Pathway
Protein Function
- Human disease related genes:Immune system diseases:Allergies and autoimmune diseases
- Disease related genes
- Human disease related genes:Immune system diseases:Other immune system diseases
- Predicted intracellular proteins
Cellular Component
Molecular Function
Biological Process
KEGG
Reactome
- R-hsa-5663205 infectious disease
- R-hsa-622312 inflammasomes
- R-hsa-168249 innate immune system
- R-hsa-9658195 leishmania infection
- R-hsa-168643 nucleotide binding domain leucine rich repeat containing receptor nlr signaling pathways
- R-hsa-9660826 purinergic signaling in leishmaniasis infection
- R-hsa-844456 the nlrp3 inflammasome
Canonical Pathways
M138 Pid thrombin par4 pathway
Mediation Categories
Clinical-translation mediationImmune mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
5 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
2 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| PKN2 | Q16513 | MEFV | O15553 | Yes | No | Yes | Sparser_ProtMapperSIGNORProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper | ProtMapper:31177443SIGNOR:27270401ProtMapper:29178647ProtMapper:33338767ProtMapper:27270401ProtMapper:31456795PhosphoSite:15934090ProtMapper:32962268PhosphoSite:27270401PhosphoSite:27030597 |
| PKN1 | Q16512 | MEFV | O15553 | Yes | No | Yes | Sparser_ProtMapperPhosphoSite_norefSIGNORProtMapperREACH_ProtMapperPhosphoSite_ProtMapper | ProtMapper:31177443SIGNOR:27270401ProtMapper:29178647ProtMapper:33338767ProtMapper:27270401ProtMapper:31456795ProtMapper:32962268 |
Protein Complex Composition
4 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| Pyrin inflammasome | CASP1MEFVPYCARD | O15553P29466Q9ULZ3 | 1:1:1 | SIGNORComplexPortal | PDB:1sc1intact:EBI-21198929PDB:1sc3PDB:6f6rPDB:3j63PDB:2hbzPDB:3ns7PDB:1rwxPDB:1rwmPDB:1rwoPDB:5mmvPDB:3d6fPDB:1rwkPDB:1rwvPDB:3e4cPDB:2hbyPDB:6n1hPDB:1bmqPDB:2h4wPDB:3d6mPDB:2h4yPDB:5fnaPDB:2hbrPDB:2h54PDB:4cg4PDB:6bz9SIGNOR:SIGNOR-C226PDB:2hbqPDB:1rwpPDB:1icePDB:5mtkPDB:2h51PDB:1sc4PDB:3d6hPDB:1rwwPDB:2fqqPDB:1rwnPDB:2h48PDB:1ibc | 279118042914803616037825147552922971818429196474 |
| MEFV | O15553 | 6 | PDB | PDB:4cg4PDB:8sdj | ||
| MEFVSFN | O15553P31947 | 3:2 | PDB | PDB:8c30PDB:8c28PDB:8c2y | ||
| MEFVPYCARD | O15553Q9ULZ3 | 0:0 | KEGG-MEDICUS |
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Western BlottingMass Spectrometry | 1 | 36398564 |
Sequence, Structure & Domains
Sequences
Length
781
Mass
86,444
Sequence
MAKTPSDHLLSTLEELVPYDFEKFKFKLQNTSVQKEHSRIPRSQIQRARPVKMATLLVTYYGEEYAVQLTLQVLRAINQRLLAEELHRAAIQEYSTQENGTDDSAASSSLGENKPRSLKTPDHPEGNEGNGPRPYGGGAASLRCSQPEAGRGLSRKPLSKRREKASEGLDAQGKPRTRSPALPGGRSPGPCRALEGGQAEVRLRRNASSAGRLQGLAGGAPGQKECRPFEVYLPSGKMRPRSLEVTISTGEKAPANPEILLTLEEKTAANLDSATEPRARPTPDGGASADLKEGPGNPEHSVTGRPPDTAASPRCHAQEGDPVDGTCVRDSCSFPEAVSGHPQASGSRSPGCPRCQDSHERKSPGSLSPQPLPQCKRHLKQVQLLFCEDHDEPICLICSLSQEHQGHRVRPIEEVALEHKKKIQKQLEHLKKLRKSGEEQRSYGEEKAVSFLKQTEALKQRVQRKLEQVYYFLEQQEHFFVASLEDVGQMVGQIRKAYDTRVSQDIALLDALIGELEAKECQSEWELLQDIGDILHRAKTVPVPEKWTTPQEIKQKIQLLHQKSEFVEKSTKYFSETLRSEMEMFNVPELIGAQAHAVNVILDAETAYPNLIFSDDLKSVRLGNKWERLPDGPQRFDSCIIVLGSPSFLSGRRYWEVEVGDKTAWILGACKTSISRKGNMTLSPENGYWVVIMMKENEYQASSVPPTRLLIKEPPKRVGIFVDYRVGSISFYNVTARSHIYTFASCSFSGPLQPIFSPGTRDGGKNTAPLTICPVGGQGPD
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=FL; IsoId=O15553-2; Sequence=Displayed; Name=2; Synonyms=D2; IsoId=O15553-1; Sequence=VSP_008223; Name=3; IsoId=O15553-3; Sequence=VSP_008223, VSP_047663
Alternative Sequence
93..303; Missing (in isoform 2 and isoform 3); 587..781; VPELIGAQAHAVNVILDAETAYPNLIFSDDLKSVRLGNKWERLPDGPQRFDSCIIVLGSPSFLSGRRYWEVEVGDKTAWILGACKTSISRKGNMTLSPENGYWVVIMMKENEYQASSVPPTRLLIKEPPKRVGIFVDYRVGSISFYNVTARSHIYTFASCSFSGPLQPIFSPGTRDGGKNTAPLTICPVGGQGPD -> DHSPQHGLGSWEERDYTQHSMQGPKQGVPCLSLLSGQCNLAPLNANAQDFFPYLIFLRSSGADWRSGTCC (in isoform 3)
3D Structural Models
Turn
50..52; 604..606; 724..727; 734..737
Helix
5..15; 18..28; 42..47; 53..60; 63..76; 80..92; 414..519; 524..528; 531..539; 551..583; 584..586; 590..594; 684..686; 762..764
Beta Strand
611..613; 619..622; 637..639; 642..645; 650..658; 665..671; 676..678; 688..695; 698..701; 707..709; 716..723; 728..733; 738..743; 752..757; 770..773
3D Structure
NMR spectroscopy (1); X-ray crystallography (10)
Domain & Motif Annotations
Compositional Bias
93..111; Polar residues; 113..126; Basic and acidic residues; 153..163; Basic residues
Motif
420..437; Nuclear localization signal
Coiled Coil
413..442
Zinc Finger
370..412; B box-type
Domain (CC)
The B box-type zinc finger interacts, possibly intramolecularly, with the pyrin domain; this may be an autoinhibitory mechanism released by PSTPIP1 binding.
Domain (FT)
1..92; Pyrin; 580..775; B30.2/SPRY
Region
93..226; Disordered; 266..280; Interaction with RELA; 270..322; Disordered; 336..373; Disordered; 420..582; Required for homotrimerization and induction of pyroptosomes
Clinical Relevance
Interaction Protein
ENSG00000103490
Interaction Count
1
Interaction Dataset
intact_biogrid