Protein detail

FLRT2

Leucine-rich repeat transmembrane protein FLRT2 (Fibronectin-like domain-containing leucine-rich transmembrane protein 2)

Entry name FLRT2	UniProt ID O43155	EVMP confidence score 0.25
Supporting publications (n) 1	Transmembrane count 1	Protein classification

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information8

Protein Names

Leucine-rich repeat transmembrane protein FLRT2 (Fibronectin-like domain-containing leucine-rich transmembrane protein 2)

Protein Function

Predicted intracellular proteins

Transmembrane

542..562; Helical

Transmembrane Count

Ensembl

ENSG00000185070

Entrez Gene Symbol

FLRT2

Supporting publications (n)

EVMP confidence score

0.25

Fluorescence & Localization5

Cell SpecificNeutrophilsSingle-Nuclei Brain Specificendothelial cellBlood Cell SpecificneutrophilSecretome LocationSecreted to bloodSecretome FunctionReceptor

Function & Pathway5

Protein Function

Predicted intracellular proteins

Cellular Component (11)

Page 1 of 2

Molecular Function (3)

Reactome (4)

Mediation Categories (2)

Adhesion and uptake mediationReceptor-signaling mediation

Relations & Evidence46

Ligand-Receptor Signaling (44)

44 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
transmembrane	transmembrane	CellPhoneDB	No	No	Yes	Yes	No
transmembrane	transmembrane	TopDB	No	No	Yes	Yes	No
transmembrane	transmembrane	LOCATE	No	No	Yes	Yes	No
transmembrane	transmembrane	Ramilowski_location	No	No	Yes	Yes	No
transmembrane	transmembrane	OmniPath	No	No	Yes	Yes	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	Yes	Yes	No
plasma_membrane	plasma_membrane	Cellinker	No	No	Yes	Yes	No
plasma_membrane	plasma_membrane	OmniPath	No	No	Yes	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	Membranome	No	No	Yes	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	CSPA	No	No	Yes	Yes	No

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Protein Complex Composition (1)

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	FLRT2 UNC5D	O43155 Q6UXZ4	0:0	ICELLNET		27091502

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Mass spectrometry	1	27234505

Sequence, Structure & Domains7

Sequences

Length

660

Mass

74,049

Sequence

MGLQTTKWPSHGAFFLKSWLIISLGLYSQVSKLLACPSVCRCDRNFVYCNERSLTSVPLGIPEGVTVLYLHNNQINNAGFPAELHNVQSVHTVYLYGNQLDEFPMNLPKNVRVLHLQENNIQTISRAALAQLLKLEELHLDDNSISTVGVEDGAFREAISLKLLFLSKNHLSSVPVGLPVDLQELRVDENRIAVISDMAFQNLTSLERLIVDGNLLTNKGIAEGTFSHLTKLKEFSIVRNSLSHPPPDLPGTHLIRLYLQDNQINHIPLTAFSNLRKLERLDISNNQLRMLTQGVFDNLSNLKQLTARNNPWFCDCSIKWVTEWLKYIPSSLNVRGFMCQGPEQVRGMAVRELNMNLLSCPTTTPGLPLFTPAPSTASPTTQPPTLSIPNPSRSYTPPTPTTSKLPTIPDWDGRERVTPPISERIQLSIHFVNDTSIQVSWLSLFTVMAYKLTWVKMGHSLVGGIVQERIVSGEKQHLSLVNLEPRSTYRICLVPLDAFNYRAVEDTICSEATTHASYLNNGSNTASSHEQTTSHSMGSPFLLAGLIGGAVIFVLVVLLSVFCWHMHKKGRYTSQKWKYNRGRRKDDYCEAGTKKDNSILEMTETSFQIVSLNNDQLLKGDFRLQPIYTPNGGINYTDCHIPNNMRYCNSSVPDLEHCHT

Domain & Motif Annotations

Compositional Bias

373..409; Low complexity

Repeat

64..85; LRR 1; 89..109; LRR 2; 110..131; LRR 3; 134..155; LRR 4; 160..181; LRR 5; 182..202; LRR 6; 205..225; LRR 7; 231..252; LRR 8; 253..274; LRR 9; 277..298; LRR 10

Domain (FT)

36..63; LRRNT; 310..362; LRRCT; 419..517; Fibronectin type-III

Region

373..413; Disordered

Supporting Publications1

PMID	Title	Abstract
37886648	Pathological mechanisms of type 1 diabetes in children: investigation of the exosomal protein expression profile.	No abstract available