Protein detail
SI1L1
Signal-induced proliferation-associated 1-like protein 1 (SIPA1-like protein 1) (High-risk human papilloma viruses E6 oncoproteins targeted protein 1) (E6-targeted protein 1)
Protein symbol SI1L1 | UniProt ID | EVMP score 0.38 |
Frequency 1 | Transmembrane count | Protein classification Predicted intracellular proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Signal-induced proliferation-associated 1-like protein 1 (SIPA1-like protein 1) (High-risk human papilloma viruses E6 oncoproteins targeted protein 1) (E6-targeted protein 1)
Protein Class
Predicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
E6TP1KIAA0440SPAR1
Gene Description
Signal induced proliferation associated 1 like 1
Chromosome
14
Position
71320449-71741229
Frequency
1
EVMP Score
0.38
Fluorescence & Localization
Cell SpecificBreast secretory cellsSingle-Nuclei Brain Specificvascular associated smooth muscle cellSecretome LocationSecreted to bloodSecretome FunctionChemokine
Function & Pathway
Protein Function
Predicted intracellular proteins
Cellular Component
Molecular Function
Reactome
Mediation Categories
Receptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
2 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| SIPA1L1 | GAK | O14976 | T | 249 | phosphorylation | REACH_ProtMapperSparser_ProtMapperProtMapper | ProtMapper:30623173 |
| SIPA1L1 | RPS6KA1 | Q15418 | S | 1,585 | phosphorylation | KEA | KEA:17570479 |
Ligand-Receptor Signaling
4 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
1 record.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| UBE3A | Q05086 | SI1L1 | O43166 | Yes | No | Yes | SIGNOR | SIGNOR:12036950 |
Protein Complex Composition
2 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| FBXL17FBXO33FHIP2AKLHL12KLHL17KLHL2KLHL3PIK3C2BSCYL1SIPA1L1TRIM47TRIM8UCK1WNK3 | O00750O43166O95198Q53G59Q5W0V3Q6TDP4Q7Z6M2Q96KG9Q96LD4Q9BYP7Q9BZR9Q9HA47Q9UF56Q9UH77 | 0:0:0:0:0:0:0:0:0:0:0:0:0:0 | hu.MAP2 | |||
| SIPA1L1SRRTSYN1TSSK2 | O43166P17600Q96PF2Q9BXP5 | 0:0:0:0 | Havugimana2012 | Havugimana2012:C_343 |
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometry | 1 | 30408591 |
Sequence, Structure & Domains
Sequences
Length
1,804
Mass
200,029
Sequence
MTSLKRSQTERPLATDRASVVGTDGTPKVHTDDFYMRRFRSQNGSLGSSVMAPVGPPRSEGSHHITSTPGVPKMGVRARIADWPPRKENIKESSRSSQEIETSSCLDSLSSKSSPVSQGSSVSLNSNDSAMLKSIQNTLKNKTRPSENMDSRFLMPEAYPSSPRKALRRIRQRSNSDITISELDVDSFDECISPTYKTGPSLHREYGSTSSIDKQGTSGESFFDLLKGYKDDKSDRGPTPTKLSDFLITGGGKGSGFSLDVIDGPISQRENLRLFKEREKPLKRRSKSETGDSSIFRKLRNAKGEELGKSSDLEDNRSEDSVRPWTCPKCFAHYDVQSILFDLNEAIMNRHNVIKRRNTTTGASAAAVASLVSGPLSHSASFSSPMGSTEDLNSKGSLSMDQGDDKSNELVMSCPYFRNEIGGEGERKISLSKSNSGSFSGCESASFESTLSSHCTNAGVAVLEVPKENLVLHLDRVKRYIVEHVDLGAYYYRKFFYQKEHWNYFGADENLGPVAVSIRREKPDEMKENGSPYNYRIIFRTSELMTLRGSVLEDAIPSTAKHSTARGLPLKEVLEHVVPELNVQCLRLAFNTPKVTEQLMKLDEQGLNYQQKVGIMYCKAGQSTEEEMYNNESAGPAFEEFLQLLGERVRLKGFEKYRAQLDTKTDSTGTHSLYTTYKDYEIMFHVSTMLPYTPNNKQQLLRKRHIGNDIVTIVFQEPGAQPFSPKNIRSHFQHVFVIVRVHNPCSDSVCYSVAVTRSRDVPSFGPPIPKGVTFPKSNVFRDFLLAKVINAENAAHKSEKFRAMATRTRQEYLKDLAEKNVTNTPIDPSGKFPFISLASKKKEKSKPYPGAELSSMGAIVWAVRAEDYNKAMELDCLLGISNEFIVLIEQETKSVVFNCSCRDVIGWTSTDTSLKIFYERGECVSVGSFINIEEIKEIVKRLQFVSKGCESVEMTLRRNGLGQLGFHVNYEGIVADVEPYGYAWQAGLRQGSRLVEICKVAVATLSHEQMIDLLRTSVTVKVVIIPPHDDCTPRRSCSETYRMPVMEYKMNEGVSYEFKFPFRNNNKWQRNASKGPHSPQVPSQVQSPMTSRLNAGKGDGKMPPPERAANIPRSISSDGRPLERRLSPGSDIYVTVSSMALARSQCRNSPSNLSSSSDTGSVGGTYRQKSMPEGFGVSRRSPASIDRQNTQSDIGGSGKSTPSWQRSEDSIADQMAYSYRGPQDFNSFVLEQHEYTEPTCHLPAVSKVLPAFRESPSGRLMRQDPVVHLSPNKQGHSDSHYSSHSSSNTLSSNASSAHSDEKWYDGDRTESELNSYNYLQGTSADSGIDTTSYGPSHGSTASLGAATSSPRSGPGKEKVAPLWHSSSEVISMADRTLETESHGLDRKTESSLSLDIHSKSQAGSTPLTRENSTFSINDAASHTSTMSSRHSASPVVFTSARSSPKEELHPAAPSQLAPSFSSSSSSSSGPRSFYPRQGATSKYLIGWKKPEGTINSVGFMDTRKRHQSDGNEIAHTRLRASTRDLRASPKPTSKSTIEEDLKKLIDLESPTPESQKSFKFHALSSPQSPFPSTPTSRRALHRTLSDESIYNSQREHFFTSRASLLDQALPNDVLFSSTYPSLPKSLPLRRPSYTLGMKSLHGEFSASDSSLTDIQETRRQPMPDPGLMPLPDTAADLDWSNLVDAAKAYEVQRASFFAASDENHRPLSAASNSDQLEDQALAQMKPYSSSKDSSPTLASKVDQLEGMLKMLREDLKKEKEDKAHLQAEVQHLREDNLRLQEESQNASDKLKKFTEWVFNTIDMS
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=E6TP1 beta; IsoId=O43166-1; Sequence=Displayed; Name=2; Synonyms=E6TP1 alpha; IsoId=O43166-2; Sequence=VSP_010917; Name=3; IsoId=O43166-3; Sequence=VSP_010917, VSP_054774
Alternative Sequence
1216..1236; Missing (in isoform 2 and isoform 3); 1728; Missing (in isoform 3)
3D Structural Models
Domain & Motif Annotations
Compositional Bias
27..36; Basic and acidic residues; 84..94; Basic and acidic residues; 95..129; Low complexity; 380..400; Polar residues; 1080..1093; Polar residues; 1144..1160; Low complexity; 1186..1205; Polar residues; 1282..1297; Low complexity; 1336..1349; Low complexity; 1379..1389; Basic and acidic residues; 1399..1431; Polar residues; 1450..1472; Low complexity; 1507..1527; Basic and acidic residues
Coiled Coil
1735..1795
Domain (FT)
613..830; Rap-GAP; 967..1045; PDZ
Region
1..157; Disordered; 277..297; Disordered; 380..401; Disordered; 1067..1128; Disordered; 1144..1207; Disordered; 1268..1306; Disordered; 1327..1366; Disordered; 1379..1475; Disordered; 1505..1536; Disordered