Protein detail
SERA
D-3-phosphoglycerate dehydrogenase (3-PGDH) (EC 1.1.1.95) (2-oxoglutarate reductase) (EC 1.1.1.399) (Malate dehydrogenase) (EC 1.1.1.37)
Protein symbol SERA | UniProt ID | EVMP score 0.38 |
Frequency 1 | Transmembrane count | Protein classification Disease related genesEnzymesHuman disease related genesMetabolic proteinsPlasma proteinsPotential drug targetsPredicted intracellular proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
D-3-phosphoglycerate dehydrogenase (3-PGDH) (EC 1.1.1.95) (2-oxoglutarate reductase) (EC 1.1.1.399) (Malate dehydrogenase) (EC 1.1.1.37)
Protein Class
Disease related genesEnzymesHuman disease related genesMetabolic proteinsPlasma proteinsPotential drug targetsPredicted intracellular proteins
Protein Function
- ENZYME proteins:Oxidoreductases
- Predicted intracellular proteins
- Potential drug targets
- Enzymes
- Disease related genes
- Human disease related genes:Congenital disorders of metabolism:Congenital disorders of amino acid metabolism
Ensembl
Entrez Gene Symbol
Gene Synonym
PDGPGDHSERA
Gene Description
Phosphoglycerate dehydrogenase
Chromosome
1
Position
119648411-119744218
Frequency
1
EVMP Score
0.38
Fluorescence & Localization
Cell SpecificCardiomyocytes
Function & Pathway
Protein Function
- ENZYME proteins:Oxidoreductases
- Predicted intracellular proteins
- Potential drug targets
- Enzymes
- Disease related genes
- Human disease related genes:Congenital disorders of metabolism:Congenital disorders of amino acid metabolism
Cellular Component
Molecular Function
Biological Process
KEGG
Mediation Categories
Clinical-translation mediationMetabolism mediation
Relations & Evidence
Enzyme-Mediated Modification
4 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| PHGDH | PRKN | O60260 | K | 330 | ubiquitination | SIGNOR | SIGNOR:32478681 |
| PHGDH | PRKCZ | Q05513 | T | 57 | phosphorylation | PhosphoSitePhosphoSite_ProtMapperProtMapper | |
| PHGDH | PRKCZ | Q05513 | T | 78 | phosphorylation | PhosphoSitePhosphoSite_ProtMapperProtMapper | |
| PHGDH | PRKCZ | Q05513 | S | 55 | phosphorylation | PhosphoSitePhosphoSite_ProtMapperProtMapper |
Ligand-Receptor Signaling
3 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
2 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| PRKN | O60260 | SERA | O43175 | Yes | No | Yes | SIGNOR | SIGNOR:32478681 |
| KPCZ | Q05513 | SERA | O43175 | Yes | No | No | iPTMnetPhosphoSite_norefProtMapperPhosphoSitePhosphoSite_ProtMapper | PhosphoSite:23374352 |
Protein Complex Composition
5 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| HT_SC_Cluster332 | CTBP2PHGDH | O43175P56545 | 1:1 | Compleat | Compleat:HC1116 | |
| PHGDH | O43175 | 2 | PDB | PDB:2g76PDB:7ewhPDB:5n6cPDB:7dkmPDB:7cvpPDB:6plgPDB:5ofmPDB:6cwaPDB:7va1PDB:5nzoPDB:6plfPDB:5nzqPDB:6rj2PDB:6rj5PDB:6rj3PDB:6rihPDB:5ofvPDB:5ofwPDB:6rj6PDB:5n53PDB:5nzp | ||
| CNN1EPN2EPN3PHGDH | O43175O95208P51911Q9H201 | 0:0:0:0 | hu.MAP2 | |||
| PHGDHRAD23BUBQLN1UBQLN4 | O43175P54727Q9NRR5Q9UMX0 | 0:0:0:0 | hu.MAP | |||
| EPN3PHGDH | O43175Q9H201 | 0:0 | hu.MAP2 |
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometry | 1 | 31718609 |
Sequence, Structure & Domains
Sequences
Length
533
Mass
56,651
Sequence
MAFANLRKVLISDSLDPCCRKILQDGGLQVVEKQNLSKEELIAELQDCEGLIVRSATKVTADVINAAEKLQVVGRAGTGVDNVDLEAATRKGILVMNTPNGNSLSAAELTCGMIMCLARQIPQATASMKDGKWERKKFMGTELNGKTLGILGLGRIGREVATRMQSFGMKTIGYDPIISPEVSASFGVQQLPLEEIWPLCDFITVHTPLLPSTTGLLNDNTFAQCKKGVRVVNCARGGIVDEGALLRALQSGQCAGAALDVFTEEPPRDRALVDHENVISCPHLGASTKEAQSRCGEEIAVQFVDMVKGKSLTGVVNAQALTSAFSPHTKPWIGLAEALGTLMRAWAGSPKGTIQVITQGTSLKNAGNCLSPAVIVGLLKEASKQADVNLVNAKLLVKEAGLNVTTSHSPAAPGEQGFGECLLAVALAGAPYQAVGLVQGTTPVLQGLNGAVFRPEVPLRRDLPLLLFRTQTSDPAMLPTMIGLLAEAGVRLLSYQTSLVSDGETWHVMGISSLLPSLEAWKQHVTEAFQFHF
3D Structural Models
Turn
135..138; 166..168; 304..306
Helix
18..25; 38..45; 61..66; 85..90; 99..102; 103..119; 121..129; 155..165; 180..185; 193..196; 197..199; 211..213; 219..222; 242..251; 271..274; 289..292
Beta Strand
8..11; 29..32; 49..53; 55..57; 72..78; 81..83; 94..96; 147..151; 170..174; 176..178; 188..190; 201..205; 216..218; 229..233; 252..260; 263..266; 278..280
3D Structure
X-ray crystallography (21)
Domain & Motif Annotations
Protein Families
D-isomer specific 2-hydroxyacid dehydrogenase family
Sequence Similarities
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.