Protein detail

MTLR

Motilin receptor (G-protein coupled receptor 38)

Entry name MTLR	UniProt ID O43193	EVMP confidence score 0.40
Supporting publications (n) 4	Transmembrane count 7	Protein classification

Basic Information

Protein Names

Motilin receptor (G-protein coupled receptor 38)

Protein Function

G-protein coupled receptors:GPCRs excl olfactory receptors

Transmembrane

36..56; Helical; Name=1; 75..94; Helical; Name=2; 113..134; Helical; Name=3; 158..178; Helical; Name=4; 247..270; Helical; Name=5; 299..320; Helical; Name=6; 335..358; Helical; Name=7

Transmembrane Count

Ensembl

ENSG00000102539

Entrez Gene Symbol

MLNR

Supporting publications (n)

EVMP confidence score

0.40

Function & Pathway

Protein Function

G-protein coupled receptors:GPCRs excl olfactory receptors

Cellular Component (2)

Molecular Function (2)

Biological Process (3)

KEGG (2)

Reactome (5)

Mediation Categories (2)

Clinical-translation mediationReceptor-signaling mediation

Relations & Evidence57

Ligand-Receptor Signaling (50)

50 records.

Category	Parent	Database	Plasma Membrane (Transmembrane)
extracellular	extracellular	OmniPath	Yes
intracellular	intracellular	GO_Intercell	Yes
intracellular	intracellular	OmniPath	Yes
transmembrane	transmembrane	UniProt_location	Yes
transmembrane	transmembrane	UniProt_topology	Yes
transmembrane	transmembrane	UniProt_keyword	Yes
transmembrane	transmembrane	GO_Intercell	Yes
transmembrane	transmembrane	CellPhoneDB	Yes
transmembrane	transmembrane	TopDB	Yes
transmembrane	transmembrane	Ramilowski_location	Yes

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Regulatory Interaction Network (6)

6 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Database	References
MOTI	P12872	MTLR	O43193	Yes	Yes	iTALKGuide2Pharma_LRdbSIGNORHINTHPMR_talklrHPMRHPRD_LRdbtalklrscConnectHPRDGuide2Pharma_CellinkerWangRamilowski2015HPMR_LRdbCellPhoneDBGuide2Pharma_talklrHPRD_talklrCellinkerSTRING_talklrGuide2PharmaCellTalkDBFantom5_LRdbHPMR_CellinkerconnectomeDB2020LRdb	Cellinker:11781320 LRdb:11461914 connectomeDB2020:16531413 HPRD:11461914 scConnect:16531413 HPRD:11259768 Guide2Pharma:11461914 HPRD:10381885 Guide2Pharma:16531413 connectomeDB2020:12054506 SIGNOR:10381885 LRdb:15677347 Cellinker:15677347 LRdb:11781320 connectomeDB2020:11461914 LRdb:11259768 connectomeDB2020:11259768 Guide2Pharma:15677347 connectomeDB2020:15677347 scConnect:11781320 scConnect:15677347 HINT:36921049 Cellinker:11461914 LRdb:10381885 CellTalkDB:10381885 Cellinker:12054506 HPMR:10381885 LRdb:12054506 Cellinker:16531413 scConnect:11461914 connectomeDB2020:10381885 LRdb:16531413 Cellinker:11259768 Cellinker:10381885 Guide2Pharma:11781320 HPRD:12054506 connectomeDB2020:11781320
MTLR	O43193	GNAI3	P08754	Yes	Yes	SIGNOR	SIGNOR:31160049
MTLR	O43193	GNAQ	P50148	Yes	Yes	SIGNOR	SIGNOR:31160049
MTLR	O43193	GNA12	Q03113	Yes	Yes	SIGNOR	SIGNOR:31160049
MTLR	O43193	GNA14	O95837	Yes	Yes	SIGNOR	SIGNOR:31160049
MTLR	O43193	GNAI1	P63096	Yes	Yes	SIGNOR	SIGNOR:31160049

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	NA	0

Sequence, Structure & Domains

Sequences

Length

412

Mass

45,344

Sequence

MGSPWNGSDGPEGAREPPWPALPPCDERRCSPFPLGALVPVTAVCLCLFVVGVSGNVVTVMLIGRYRDMRTTTNLYLGSMAVSDLLILLGLPFDLYRLWRSRPWVFGPLLCRLSLYVGEGCTYATLLHMTALSVERYLAICRPLRARVLVTRRRVRALIAVLWAVALLSAGPFLFLVGVEQDPGISVVPGLNGTARIASSPLASSPPLWLSRAPPPSPPSGPETAEAAALFSRECRPSPAQLGALRVMLWVTTAYFFLPFLCLSILYGLIGRELWSSRRPLRGPAASGRERGHRQTVRVLLVVVLAFIICWLPFHVGRIIYINTEDSRMMYFSQYFNIVALQLFYLSASINPILYNLISKKYRAAAFKLLLARKSRPRGFHRSRDTAGEVAGDTGGDTVGYTETSANVKTMG

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=A; IsoId=O43193-1; Sequence=Displayed; Name=B; IsoId=O43193-2; Sequence=VSP_001894

Alternative Sequence

301..412; LVVVLAFIICWLPFHVGRIIYINTEDSRMMYFSQYFNIVALQLFYLSASINPILYNLISKKYRAAAFKLLLARKSRPRGFHRSRDTAGEVAGDTGGDTVGYTETSANVKTMG -> RKWSRRGSKDACLQSAPPGTAQTLGPLPLLAQLWAPLPAPFPISIPASTRRGGGSGIYNLLVALPRWQNHLHKHGRFADDVLLSVL (in isoform B)

3D Structural Models

Turn

356..358

Helix

35..65; 72..88; 91..99; 108..140; 152..169; 171..174; 226..230; 242..252; 254..274; 293..321; 327..355; 360..370

3D Structure

Electron microscopy (4)

Domain & Motif Annotations

Protein Families

G-protein coupled receptor 1 family

Sequence Similarities

Belongs to the G-protein coupled receptor 1 family.

Clinical Relevance

Related Diseases (8)

Bowel habit change Digestive system disease Dyspepsia Gastroduodenal motor/secretory disorder Gastro-oesophageal reflux disease Irritable bowel syndrome Oesophagus motility disorder Pain

Biomarker

Investigative; Phase 1; Preclinical; Phase 2; Discontinued in Phase 2

Drugs (6)

ATILMOTIN NULL CAMICINAL MOTILIN MITEMCINAL FUMARATE MITEMCINAL

Supporting Publications4

PMID	Title	Related sentences
31737616	Bone Marrow Mesenchymal Stem Cells' Secretome Exerts Neuroprotective Effects in a Parkinson's Disease Rat Model.	No related sentences available
38343172	Analysis of secreted small extracellular vesicles from activated human microglial cell lines reveals distinct pro- and anti-inflammatory proteomic profiles.	No related sentences available
39025337	Shotgun proteomics of thyroid carcinoma exosomes - Insight into the role of exosomal proteins in carcinogenesis and thyroid homeostasis.	No related sentences available
40595564	Enrichment of extracellular vesicles using Mag-Net for the analysis of the plasma proteome.	No related sentences available