Protein detail
MTLR
Motilin receptor (G-protein coupled receptor 38)
Protein symbol MTLR | UniProt ID | EVMP score 0.50 |
Frequency 4 | Transmembrane count 7 | Protein classification |
Basic Information
Protein Names
Motilin receptor (G-protein coupled receptor 38)
Protein Function
G-protein coupled receptors:GPCRs excl olfactory receptors
Transmembrane
36..56; Helical; Name=1; 75..94; Helical; Name=2; 113..134; Helical; Name=3; 158..178; Helical; Name=4; 247..270; Helical; Name=5; 299..320; Helical; Name=6; 335..358; Helical; Name=7
Transmembrane Count
7
Ensembl
Entrez Gene Symbol
Frequency
4
EVMP Score
0.50
Fluorescence & Localization
Function & Pathway
Protein Function
G-protein coupled receptors:GPCRs excl olfactory receptors
Cellular Component
Biological Process
Reactome
Mediation Categories
Clinical-translation mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
50 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | Cellinker | No | Yes | No | Yes | No |
| receptor | receptor | scConnect | No | Yes | No | Yes | No |
| receptor | receptor | connectomeDB2020 | No | Yes | No | Yes | No |
| receptor | receptor | iTALK | No | Yes | No | Yes | No |
| receptor | receptor | Almen2009 | No | Yes | No | Yes | No |
| receptor | receptor | CellCellInteractions | No | Yes | No | Yes | No |
| gpcr | receptor | GPCRdb | No | Yes | No | Yes | No |
| peptide | receptor | HGNC | No | Yes | No | Yes | No |
| receptor | receptor | HGNC | No | Yes | No | Yes | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | No | Yes | No |
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Regulatory Interaction Network
6 records.
Protein Complex Composition
0 records.
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | NA | 0 |
Sequence, Structure & Domains
Sequences
Length
412
Mass
45,344
Sequence
MGSPWNGSDGPEGAREPPWPALPPCDERRCSPFPLGALVPVTAVCLCLFVVGVSGNVVTVMLIGRYRDMRTTTNLYLGSMAVSDLLILLGLPFDLYRLWRSRPWVFGPLLCRLSLYVGEGCTYATLLHMTALSVERYLAICRPLRARVLVTRRRVRALIAVLWAVALLSAGPFLFLVGVEQDPGISVVPGLNGTARIASSPLASSPPLWLSRAPPPSPPSGPETAEAAALFSRECRPSPAQLGALRVMLWVTTAYFFLPFLCLSILYGLIGRELWSSRRPLRGPAASGRERGHRQTVRVLLVVVLAFIICWLPFHVGRIIYINTEDSRMMYFSQYFNIVALQLFYLSASINPILYNLISKKYRAAAFKLLLARKSRPRGFHRSRDTAGEVAGDTGGDTVGYTETSANVKTMG
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=A; IsoId=O43193-1; Sequence=Displayed; Name=B; IsoId=O43193-2; Sequence=VSP_001894
Alternative Sequence
301..412; LVVVLAFIICWLPFHVGRIIYINTEDSRMMYFSQYFNIVALQLFYLSASINPILYNLISKKYRAAAFKLLLARKSRPRGFHRSRDTAGEVAGDTGGDTVGYTETSANVKTMG -> RKWSRRGSKDACLQSAPPGTAQTLGPLPLLAQLWAPLPAPFPISIPASTRRGGGSGIYNLLVALPRWQNHLHKHGRFADDVLLSVL (in isoform B)
3D Structural Models
Turn
356..358
Helix
35..65; 72..88; 91..99; 108..140; 152..169; 171..174; 226..230; 242..252; 254..274; 293..321; 327..355; 360..370
3D Structure
Electron microscopy (4)
Domain & Motif Annotations
Protein Families
G-protein coupled receptor 1 family
Sequence Similarities
Belongs to the G-protein coupled receptor 1 family.
Clinical Relevance
Related Diseases
Biomarker
Investigative; Phase 1; Preclinical; Phase 2; Discontinued in Phase 2