Protein detail

MTLR

Motilin receptor (G-protein coupled receptor 38)

Entry name MTLR	UniProt ID O43193	EVMP confidence score 0.50
Supporting publications (n) 4	Transmembrane count 7	Protein classification

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information8

Protein Names

Motilin receptor (G-protein coupled receptor 38)

Protein Function

G-protein coupled receptors:GPCRs excl olfactory receptors

Transmembrane

36..56; Helical; Name=1; 75..94; Helical; Name=2; 113..134; Helical; Name=3; 158..178; Helical; Name=4; 247..270; Helical; Name=5; 299..320; Helical; Name=6; 335..358; Helical; Name=7

Transmembrane Count

Ensembl

ENSG00000102539

Entrez Gene Symbol

MLNR

Supporting publications (n)

EVMP confidence score

0.50

Function & Pathway7

Protein Function

G-protein coupled receptors:GPCRs excl olfactory receptors

Cellular Component (2)

Molecular Function (2)

Biological Process (3)

KEGG (2)

Reactome (5)

Mediation Categories (2)

Clinical-translation mediationReceptor-signaling mediation

Relations & Evidence57

Ligand-Receptor Signaling (50)

50 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	Cellinker	No	Yes	No	Yes	No
receptor	receptor	scConnect	No	Yes	No	Yes	No
receptor	receptor	connectomeDB2020	No	Yes	No	Yes	No
receptor	receptor	iTALK	No	Yes	No	Yes	No
receptor	receptor	Almen2009	No	Yes	No	Yes	No
receptor	receptor	CellCellInteractions	No	Yes	No	Yes	No
gpcr	receptor	GPCRdb	No	Yes	No	Yes	No
peptide	receptor	HGNC	No	Yes	No	Yes	No
receptor	receptor	HGNC	No	Yes	No	Yes	No
transmembrane	transmembrane_predicted	Phobius	No	No	No	Yes	No

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Regulatory Interaction Network (6)

6 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
MOTI	P12872	MTLR	O43193	Yes	Yes	No	iTALKGuide2Pharma_LRdbSIGNORHINTHPMR_talklrHPMRHPRD_LRdbtalklrscConnectHPRDGuide2Pharma_CellinkerWangRamilowski2015HPMR_LRdbCellPhoneDBGuide2Pharma_talklrHPRD_talklrCellinkerSTRING_talklrGuide2PharmaCellTalkDBFantom5_LRdbHPMR_CellinkerconnectomeDB2020LRdb	Cellinker:11781320 LRdb:11461914 connectomeDB2020:16531413 HPRD:11461914 scConnect:16531413 HPRD:11259768 Guide2Pharma:11461914 HPRD:10381885 Guide2Pharma:16531413 connectomeDB2020:12054506 SIGNOR:10381885 LRdb:15677347 Cellinker:15677347 LRdb:11781320 connectomeDB2020:11461914 LRdb:11259768 connectomeDB2020:11259768 Guide2Pharma:15677347 connectomeDB2020:15677347 scConnect:11781320 scConnect:15677347 HINT:36921049 Cellinker:11461914 LRdb:10381885 CellTalkDB:10381885 Cellinker:12054506 HPMR:10381885 LRdb:12054506 Cellinker:16531413 scConnect:11461914 connectomeDB2020:10381885 LRdb:16531413 Cellinker:11259768 Cellinker:10381885 Guide2Pharma:11781320 HPRD:12054506 connectomeDB2020:11781320
MTLR	O43193	GNAI3	P08754	Yes	Yes	No	SIGNOR	SIGNOR:31160049
MTLR	O43193	GNAQ	P50148	Yes	Yes	No	SIGNOR	SIGNOR:31160049
MTLR	O43193	GNA12	Q03113	Yes	Yes	No	SIGNOR	SIGNOR:31160049
MTLR	O43193	GNA14	O95837	Yes	Yes	No	SIGNOR	SIGNOR:31160049
MTLR	O43193	GNAI1	P63096	Yes	Yes	No	SIGNOR	SIGNOR:31160049

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	NA	0

Sequence, Structure & Domains10

Sequences

Length

412

Mass

45,344

Sequence

MGSPWNGSDGPEGAREPPWPALPPCDERRCSPFPLGALVPVTAVCLCLFVVGVSGNVVTVMLIGRYRDMRTTTNLYLGSMAVSDLLILLGLPFDLYRLWRSRPWVFGPLLCRLSLYVGEGCTYATLLHMTALSVERYLAICRPLRARVLVTRRRVRALIAVLWAVALLSAGPFLFLVGVEQDPGISVVPGLNGTARIASSPLASSPPLWLSRAPPPSPPSGPETAEAAALFSRECRPSPAQLGALRVMLWVTTAYFFLPFLCLSILYGLIGRELWSSRRPLRGPAASGRERGHRQTVRVLLVVVLAFIICWLPFHVGRIIYINTEDSRMMYFSQYFNIVALQLFYLSASINPILYNLISKKYRAAAFKLLLARKSRPRGFHRSRDTAGEVAGDTGGDTVGYTETSANVKTMG

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=A; IsoId=O43193-1; Sequence=Displayed; Name=B; IsoId=O43193-2; Sequence=VSP_001894

Alternative Sequence

301..412; LVVVLAFIICWLPFHVGRIIYINTEDSRMMYFSQYFNIVALQLFYLSASINPILYNLISKKYRAAAFKLLLARKSRPRGFHRSRDTAGEVAGDTGGDTVGYTETSANVKTMG -> RKWSRRGSKDACLQSAPPGTAQTLGPLPLLAQLWAPLPAPFPISIPASTRRGGGSGIYNLLVALPRWQNHLHKHGRFADDVLLSVL (in isoform B)

3D Structural Models

Turn

356..358

Helix

35..65; 72..88; 91..99; 108..140; 152..169; 171..174; 226..230; 242..252; 254..274; 293..321; 327..355; 360..370

3D Structure

Electron microscopy (4)

Domain & Motif Annotations

Protein Families

G-protein coupled receptor 1 family

Sequence Similarities

Belongs to the G-protein coupled receptor 1 family.

Clinical Relevance3

Related Diseases (8)

Bowel habit change Digestive system disease Dyspepsia Gastroduodenal motor/secretory disorder Gastro-oesophageal reflux disease Irritable bowel syndrome Oesophagus motility disorder Pain

Biomarker

Investigative; Phase 1; Preclinical; Phase 2; Discontinued in Phase 2

Drugs (6)

ATILMOTIN NULL CAMICINAL MOTILIN MITEMCINAL FUMARATE MITEMCINAL

Supporting Publications4

PMID	Title	Abstract
31737616	Bone Marrow Mesenchymal Stem Cells' Secretome Exerts Neuroprotective Effects in a Parkinson's Disease Rat Model.	No abstract available
38343172	Analysis of secreted small extracellular vesicles from activated human microglial cell lines reveals distinct pro- and anti-inflammatory proteomic profiles.	No abstract available
39025337	Shotgun proteomics of thyroid carcinoma exosomes - Insight into the role of exosomal proteins in carcinogenesis and thyroid homeostasis.	No abstract available
40595564	Enrichment of extracellular vesicles using Mag-Net for the analysis of the plasma proteome.	No abstract available