Protein detail
SPIT1
Kunitz-type protease inhibitor 1 (Hepatocyte growth factor activator inhibitor type 1) (HAI-1)
Entry name SPIT1 | UniProt ID | EVMP confidence score 0.72 |
Supporting publications (n) 11 | Transmembrane count | Protein classification Cancer-related genesEssential proteinsPlasma proteinsPredicted intracellular proteinsPredicted membrane proteinsPredicted secreted proteinsTransporters |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information11
Protein Names
Kunitz-type protease inhibitor 1 (Hepatocyte growth factor activator inhibitor type 1) (HAI-1)
Protein Class (7)
Cancer-related genesEssential proteinsPlasma proteinsPredicted intracellular proteinsPredicted membrane proteinsPredicted secreted proteinsTransporters
Protein Function (4)
- Predicted intracellular proteins
- Cancer-related genes:Candidate cancer biomarkers
- Predicted secreted proteins
- Transporters:Accessory Factors Involved in Transport
Ensembl
Entrez Gene Symbol
Gene Synonym (3)
HAIHAI-1MANSC2
Gene Description
Serine peptidase inhibitor, Kunitz type 1
Chromosome
15
Position
40844018-40858207
Supporting publications (n)
11
EVMP confidence score
0.72
Fluorescence & Localization5
Tissue SpecificepididymisCell SpecificTuft cellsSingle-Nuclei Brain Specificendothelial cellBlood Cell SpecificneutrophilBlood Lineage Specificgranulocytes
Function & Pathway7
Protein Function (4)
- Predicted intracellular proteins
- Cancer-related genes:Candidate cancer biomarkers
- Predicted secreted proteins
- Transporters:Accessory Factors Involved in Transport
Cellular Component (6)
Molecular Function (2)
Biological Process (3)
Reactome (4)
Mediation Categories
Receptor-signaling mediation
Relations & Evidence30
Ligand-Receptor Signaling (26)
26 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| extracellular | extracellular | LOCATE | No | No | Yes | Yes | No |
| extracellular | extracellular | OmniPath | No | No | Yes | Yes | No |
| intracellular | intracellular | LOCATE | No | No | Yes | Yes | No |
| intracellular | intracellular | ComPPI | No | No | Yes | Yes | No |
| intracellular | intracellular | GO_Intercell | No | No | Yes | Yes | No |
| intracellular | intracellular | UniProt_location | No | No | Yes | Yes | No |
| intracellular | intracellular | OmniPath | No | No | Yes | Yes | No |
| transmembrane_predicted | transmembrane | OmniPath | No | No | Yes | Yes | No |
| transmembrane | transmembrane | TopDB | No | No | Yes | Yes | No |
| transmembrane | transmembrane | LOCATE | No | No | Yes | Yes | No |
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Protein Complex Composition (3)
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometryR Sequencing | 1 | 40326690 |
Sequence, Structure & Domains11
Sequences
Length
529
Mass
58,398
Sequence
MAPARTMARARLAPAGIPAVALWLLCTLGLQGTQAGPPPAPPGLPAGADCLNSFTAGVPGFVLDTNASVSNGATFLESPTVRRGWDCVRACCTTQNCNLALVELQPDRGEDAIAACFLINCLYEQNFVCKFAPREGFINYLTREVYRSYRQLRTQGFGGSGIPKAWAGIDLKVQPQEPLVLKDVENTDWRLLRGDTDVRVERKDPNQVELWGLKEGTYLFQLTVTSSDHPEDTANVTVTVLSTKQTEDYCLASNKVGRCRGSFPRWYYDPTEQICKSFVYGGCLGNKNNYLREEECILACRGVQGGPLRGSSGAQATFPQGPSMERRHPVCSGTCQPTQFRCSNGCCIDSFLECDDTPNCPDASDEAACEKYTSGFDELQRIHFPSDKGHCVDLPDTGLCKESIPRWYYNPFSEHCARFTYGGCYGNKNNFEEEQQCLESCRGISKKDVFGLRREIPIPSTGSVEMAVAVFLVICIVVVVAILGYCFFKNQRKDFHGHHHHPPPTPASSTVSTTEDTEHLVYNHTTRPL
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=HAI-1B; IsoId=O43278-1; Sequence=Displayed; Name=2; Synonyms=HAI-1A; IsoId=O43278-2; Sequence=VSP_013019
Alternative Sequence
306..321; Missing (in isoform 2)
3D Structural Models
Turn
70..72; 143..145; 150..152; 270..272
Helix
50..53; 66..69; 84..93; 146..149; 246..250; 293..300
Beta Strand
54..56; 61..63; 75..77; 99..104; 106..108; 113..119; 131..133; 135..142; 169..173; 177..180; 190..196; 199..201; 209..212; 215..222; 234..240; 263..268; 273..280; 282..284; 290..292
3D Structure
NMR spectroscopy (1); X-ray crystallography (6)
Domain & Motif Annotations
Domain (CC)
This inhibitor contains two inhibitory domains.
Domain (FT)
57..140; MANSC; 250..300; BPTI/Kunitz inhibitor 1; 334..370; LDL-receptor class A; 391..441; BPTI/Kunitz inhibitor 2