Protein detail
MTSS1
Protein MTSS 1 (Metastasis suppressor YGL-1) (Metastasis suppressor protein 1) (Missing in metastasis protein)
Protein symbol MTSS1 | UniProt ID | EVMP score 0.38 |
Frequency 1 | Transmembrane count | Protein classification Plasma proteinsPredicted intracellular proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Protein MTSS 1 (Metastasis suppressor YGL-1) (Metastasis suppressor protein 1) (Missing in metastasis protein)
Protein Class
Plasma proteinsPredicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
KIAA0429MIMMIMAMIMB
Gene Description
MTSS I-BAR domain containing 1
Chromosome
8
Position
124550784-124728473
Frequency
1
EVMP Score
0.38
Fluorescence & Localization
Tissue Specificblood vesselCell SpecificCytotrophoblastsSingle-Nuclei Brain Specificendothelial cellSecretome LocationSecreted to extracellular matrixSecretome FunctionEnzyme
Function & Pathway
Protein Function
Predicted intracellular proteins
Cellular Component
Molecular Function
Biological Process
Canonical Pathways
- M5060 Sa fas signaling
- M7997 Sa caspase cascade
- M197 Pid hiv nef pathway
Mediation Categories
Fusion and delivery mediation
Relations & Evidence
Enzyme-Mediated Modification
1 record.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| MTSS1 | CSNK1D | P48730 | S | 322 | phosphorylation | PhosphoSite_MIMPMIMPProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper | ProtMapper:24318128 |
Ligand-Receptor Signaling
4 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
6 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| MTSS1 | O43312 | GLI1 | P08151 | Yes | Yes | No | WangSIGNORSignaLink3 | SignaLink3:15545630SignaLink3:23331499SIGNOR:15545630SIGNOR:17845852 |
| MTSS1 | O43312 | GLIS2 | Q9BZE0 | Yes | Yes | No | SignaLink3 | SignaLink3:23331499SignaLink3:15545630 |
| MTSS1 | O43312 | SUFU | Q9UMX1 | Yes | Yes | No | SIGNORSignaLink3 | SignaLink3:23331499SIGNOR:15545630SignaLink3:15545630 |
| MTSS1 | O43312 | RAC1 | P63000 | Yes | Yes | No | SIGNORSignaLink3 | SignaLink3:23331499SIGNOR:16280553SignaLink3:16280553 |
| KC1D | P48730 | MTSS1 | O43312 | Yes | No | Yes | PhosphoSite_MIMPMIMPiPTMnetSIGNORProtMapperELMREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper | ProtMapper:24318128PhosphoSite:24318128SIGNOR:24318128ELM:24318128 |
| COMPLEX:P63208_Q13616_Q9Y297 | MTSS1 | O43312 | Yes | No | Yes | SIGNOR | SIGNOR:24318128 |
Protein Complex Composition
0 records.
Sequence, Structure & Domains
Sequences
Length
755
Mass
82,251
Sequence
MEAVIEKECSALGGLFQTIISDMKGSYPVWEDFINKAGKLQSQLRTTVVAAAAFLDAFQKVADMATNTRGGTREIGSALTRMCMRHRSIEAKLRQFSSALIDCLINPLQEQMEEWKKVANQLDKDHAKEYKKARQEIKKKSSDTLKLQKKAKKGRGDIQPQLDSALQDVNDKYLLLEETEKQAVRKALIEERGRFCTFISMLRPVIEEEISMLGEITHLQTISEDLKSLTMDPHKLPSSSEQVILDLKGSDYSWSYQTPPSSPSTTMSRKSSVCSSLNSVNSSDSRSSGSHSHSPSSHYRYRSSNLAQQAPVRLSSVSSHDSGFISQDAFQSKSPSPMPPEAPNQLSNGFSHYSLSSESHVGPTGAGLFPHCLPASRLLPRVTSVHLPDYAHYYTIGPGMFPSSQIPSWKDWAKPGPYDQPLVNTLQRRKEKREPDPNGGGPTTASGPPAAAEEAQRPRSMTVSAATRPGEEMEACEELALALSRGLQLDTQRSSRDSLQCSSGYSTQTTTPCCSEDTIPSQVSDYDYFSVSGDQEADQQEFDKSSTIPRNSDISQSYRRMFQAKRPASTAGLPTTLGPAMVTPGVATIRRTPSTKPSVRRGTIGAGPIPIKTPVIPVKTPTVPDLPGVLPAPPDGPEERGEHSPESPSVGEGPQGVTSMPSSMWSGQASVNPPLPGPKPSIPEEHRQAIPESEAEDQEREPPSATVSPGQIPESDPADLSPRDTPQGEDMLNAIRRGVKLKKTTTNDRSAPRFS
Alternative Products
Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=O43312-1; Sequence=Displayed; Name=2; IsoId=O43312-2; Sequence=VSP_007420, VSP_007421; Name=3; IsoId=O43312-4; Sequence=VSP_016216; Name=4; IsoId=O43312-5; Sequence=VSP_054702
Alternative Sequence
1..200; Missing (in isoform 2); 153; K -> KVDTL (in isoform 4); 345..426; Missing (in isoform 2); 346..409; LSNGFSHYSLSSESHVGPTGAGLFPHCLPASRLLPRVTSVHLPDYAHYYTIGPGMFPSSQIPSW -> NSSSSASSEASETCQSVSECSSPTSVSSGSTMGAWVSTE (in isoform 3)
3D Structural Models
Helix
729..737
3D Structure
X-ray crystallography (1)
Domain & Motif Annotations
Compositional Bias
443..453; Low complexity; 608..623; Low complexity; 656..671; Polar residues
Coiled Coil
108..155
Domain (CC)
The WH2 motif at the C-terminus binds to actin monomers.
Domain (FT)
1..250; IMD; 727..744; WH2
Region
139..159; Disordered; 255..305; Disordered; 327..351; Disordered; 428..470; Disordered; 490..513; Disordered; 563..755; Disordered
Protein Families
MTSS family
Sequence Similarities
Belongs to the MTSS family.