Protein detail
M3K7
Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1)
Entry name M3K7 | UniProt ID | EVMP confidence score 0.38 |
Supporting publications (n) 1 | Transmembrane count | Protein classification Disease related genesEnzymesHuman disease related genesPotential drug targetsPredicted intracellular proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information11
Protein Names
Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1)
Protein Class (5)
Disease related genesEnzymesHuman disease related genesPotential drug targetsPredicted intracellular proteins
Protein Function (8)
- Kinases:STE Ser/Thr protein kinases
- Human disease related genes:Congenital malformations:Congenital malformations of the musculoskeletal system
- Predicted intracellular proteins
- ENZYME proteins:Transferases
- Potential drug targets
- Enzymes
- Disease related genes
- Human disease related genes:Congenital malformations:Other congenital malformations
Ensembl
Entrez Gene Symbol
Gene Synonym (2)
MEKK7TAK1
Gene Description
Mitogen-activated protein kinase kinase kinase 7
Chromosome
6
Position
90513573-90587086
Supporting publications (n)
1
EVMP confidence score
0.38
Fluorescence & Localization3
Tissue Specificlymphoid tissueCell SpecificB-cellsSingle-Nuclei Brain Specificcentral nervous system macrophage
Function & Pathway8
Protein Function (8)
- Kinases:STE Ser/Thr protein kinases
- Human disease related genes:Congenital malformations:Congenital malformations of the musculoskeletal system
- Predicted intracellular proteins
- ENZYME proteins:Transferases
- Potential drug targets
- Enzymes
- Disease related genes
- Human disease related genes:Congenital malformations:Other congenital malformations
Cellular Component (7)
Molecular Function (18)
- GO:0000287 magnesium ion binding
- GO:0001223 transcription coactivator binding
- GO:0004674 protein serine/threonine kinase activity
- GO:0004707 MAP kinase activity
- GO:0004709 MAP kinase kinase kinase activity
- GO:0005114 type II transforming growth factor beta receptor binding
- GO:0005515 protein binding
- GO:0005524 ATP binding
- GO:0008349 MAP kinase kinase kinase kinase activity
- GO:0030971 receptor tyrosine kinase binding
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Biological Process (3)
KEGG (29)
- hsa04010 MAPK signaling pathway
- KEGG:hsa04064 NF-kappa B signaling pathway
- KEGG:hsa04140 Autophagy - animal
- KEGG:hsa04152 AMPK signaling pathway
- KEGG:hsa04310 Wnt signaling pathway
- KEGG:hsa04380 Osteoclast differentiation
- KEGG:hsa04520 Adherens junction
- KEGG:hsa04613 Neutrophil extracellular trap formation
- KEGG:hsa04620 Toll-like receptor signaling pathway
- KEGG:hsa04621 NOD-like receptor signaling pathway
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Reactome (44)
- R-hsa-450302 activated tak1 mediates p38 mapk activation
- R-hsa-1169091 activation of nf kappab in b cells
- R-hsa-1280218 adaptive immune system
- R-hsa-9645460 alpha protein kinase 1 signaling pathway
- R-hsa-3858494 beta catenin independent wnt signaling
- R-hsa-4086398 ca2 pathway
- R-hsa-5607764 clec7a dectin 1 signaling
- R-hsa-1280215 cytokine signaling in immune system
- R-hsa-5621481 c type lectin receptors clrs
- R-hsa-73887 death receptor signaling
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Canonical Pathways (2)
- M236 Pid delta np63 pathway
- M19 Pid p73pathway
Mediation Categories (4)
Clinical-translation mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence94
Enzyme-Mediated Modification (20)
20 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| MAP3K7 | PPP6C | O00743 | T | 187 | dephosphorylation | SIGNORDEPOD | DEPOD:17079228SIGNOR:17079228 |
| MAP3K7 | PPP6C | O00743 | T | 187 | phosphorylation | SIGNOR_ProtMapperProtMapper | ProtMapper:17079228 |
| MAP3K7 | TRAF2 | Q12933 | K | 158 | ubiquitination | SIGNOR | SIGNOR:20038579 |
| MAP3K7 | TRAF6 | Q9Y4K3 | K | 34 | ubiquitination | SIGNOR | SIGNOR:18758450 |
| MAP3K7 | TRIM8 | Q9BZR9 | K | 158 | polyubiquitination | SIGNOR | SIGNOR:22084099 |
| MAP3K7 | PPP2CA | P67775 | T | 187 | dephosphorylation | SIGNORDEPOD | DEPOD:17079228SIGNOR:17079228 |
| MAP3K7 | PPP2CA | P67775 | T | 187 | phosphorylation | SIGNOR_ProtMapperProtMapper | ProtMapper:17079228 |
| MAP3K7 | PPP2CB | P62714 | T | 187 | dephosphorylation | DEPOD | DEPOD:17079228 |
| MAP3K7 | PPM1B | O75688 | S | 192 | dephosphorylation | DEPOD | DEPOD:11104763 |
| MAP3K7 | IL1B | P01584 | T | 187 | phosphorylation | REACH_ProtMapperSparser_ProtMapperProtMapper | ProtMapper:23646170ProtMapper:28507161 |
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Ligand-Receptor Signaling (9)
9 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | No | Yes | No | No | No |
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
| receptor | receptor | scConnect | No | Yes | No | No | No |
Regulatory Interaction Network (52)
52 records.
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Protein Complex Composition (12)
Sequence, Structure & Domains14
Sequences
Length
606
Mass
67,196
Sequence
MSTASAASSSSSSSAGEMIEAPSQVLNFEEIDYKEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESERKAFIVELRQLSRVNHPNIVKLYGACLNPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQTHMTNNKGSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGTRPPLIKNLPKPIESLMTRCWSKDPSQRPSMEEIVKIMTHLMRYFPGADEPLQYPCQYSDEGQSNSATSTGSFMDIASTNTSNKSDTNMEQVPATNDTIKRLESKLLKNQAKQQSESGRLSLGASRGSSVESLPPTSEGKRMSADMSEIEARIAATTAYSKPKRGHRKTASFGNILDVPEIVISGNGQPRRRSIQDLTVTGTEPGQVSSRSSSPSVRMITTSGPTSEKPTRSHPWTPDDSTDTNGSDNSIPMAYLTLDHQLQPLAPCPNSKESMAVFEQHCKMAQEYMKVQTEIALLLQRKQELVAELDQDEKDQQNTSRLVQEHKKLLDENKSLSTYYQQCKKQLEVIRSQQQKRQGTS
Alternative Products
Event=Alternative splicing; Named isoforms=4; Name=1B; IsoId=O43318-1; Sequence=Displayed; Name=1A; IsoId=O43318-2; Sequence=VSP_004886; Name=1C; IsoId=O43318-3; Sequence=VSP_004887, VSP_004888; Name=1D; IsoId=O43318-4; Sequence=VSP_004886, VSP_004887, VSP_004888
Alternative Sequence
404..430; Missing (in isoform 1A and isoform 1D); 509..518; PLAPCPNSKE -> ARTSCRTGPG (in isoform 1C and isoform 1D); 519..606; Missing (in isoform 1C and isoform 1D)
3D Structural Models
Turn
97..100; 166..169; 228..231; 292..295
Helix
33..35; 68..70; 71..83; 112..117; 127..145; 159..161; 182..186; 193..195; 198..201; 209..224; 236..244; 257..266; 271..273; 277..288
Beta Strand
36..44; 46..57; 59..64; 92..96; 101..105; 108..111; 118..123; 148..150; 162..165; 170..173; 300..302
3D Structure
X-ray crystallography (24)
Domain & Motif Annotations
Compositional Bias
306..338; Polar residues; 361..375; Low complexity; 443..452; Polar residues; 453..463; Low complexity; 464..473; Polar residues
Domain (FT)
36..291; Protein kinase
Region
1..300; Interaction with MAPK8IP1; 301..338; Disordered; 354..391; Disordered; 443..493; Disordered
Protein Families (3)
- Protein kinase superfamily
- STE Ser/Thr protein kinase family
- MAP kinase kinase kinase subfamily
Sequence Similarities
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
Clinical Relevance7
Disease Involvement
Disease variant
Related Diseases
Biomarker
Investigative
Interaction Protein (11)
ENSG00000055208ENSG00000100324ENSG00000104365ENSG00000105401ENSG00000119414ENSG00000121653ENSG00000150991ENSG00000157625ENSG00000168610ENSG00000175104ENSG00000213341
Interaction Count
11
Interaction Dataset (4)
intact_biogrid_opencellintact_biogrid_opencell_bioplexintact_biogridintact_biogrid_bioplex
Supporting Publications1
| PMID | Title | Abstract |
|---|---|---|
| 27605433 | Secreted primary human malignant mesothelioma exosome signature reflects oncogenic cargo. | No abstract available |