Protein detail
M3K7
Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1)
Protein symbol M3K7 | UniProt ID | EVMP score 0.38 |
Frequency 1 | Transmembrane count | Protein classification Disease related genesEnzymesHuman disease related genesPotential drug targetsPredicted intracellular proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1)
Protein Class
Disease related genesEnzymesHuman disease related genesPotential drug targetsPredicted intracellular proteins
Protein Function
- Kinases:STE Ser/Thr protein kinases
- Human disease related genes:Congenital malformations:Congenital malformations of the musculoskeletal system
- Predicted intracellular proteins
- ENZYME proteins:Transferases
- Potential drug targets
- Enzymes
- Disease related genes
- Human disease related genes:Congenital malformations:Other congenital malformations
Ensembl
Entrez Gene Symbol
Gene Synonym
MEKK7TAK1
Gene Description
Mitogen-activated protein kinase kinase kinase 7
Chromosome
6
Position
90513573-90587086
Frequency
1
EVMP Score
0.38
Fluorescence & Localization
Tissue Specificlymphoid tissueCell SpecificB-cellsSingle-Nuclei Brain Specificcentral nervous system macrophage
Function & Pathway
Protein Function
- Kinases:STE Ser/Thr protein kinases
- Human disease related genes:Congenital malformations:Congenital malformations of the musculoskeletal system
- Predicted intracellular proteins
- ENZYME proteins:Transferases
- Potential drug targets
- Enzymes
- Disease related genes
- Human disease related genes:Congenital malformations:Other congenital malformations
Cellular Component
Molecular Function
- GO:0000287 magnesium ion binding
- GO:0001223 transcription coactivator binding
- GO:0004674 protein serine/threonine kinase activity
- GO:0004707 MAP kinase activity
- GO:0004709 MAP kinase kinase kinase activity
- GO:0005114 type II transforming growth factor beta receptor binding
- GO:0005515 protein binding
- GO:0005524 ATP binding
- GO:0008349 MAP kinase kinase kinase kinase activity
- GO:0030971 receptor tyrosine kinase binding
- GO:0031625 ubiquitin protein ligase binding
- GO:0035173 histone kinase activity
- GO:0042802 identical protein binding
- GO:0097110 scaffold protein binding
- GO:0106310 protein serine kinase activity
- GO:0120283 protein serine/threonine kinase binding
- GO:0140297 DNA-binding transcription factor binding
- GO:1990450 linear polyubiquitin binding
Biological Process
KEGG
- hsa04010 MAPK signaling pathway
- KEGG:hsa04064 NF-kappa B signaling pathway
- KEGG:hsa04140 Autophagy - animal
- KEGG:hsa04152 AMPK signaling pathway
- KEGG:hsa04310 Wnt signaling pathway
- KEGG:hsa04380 Osteoclast differentiation
- KEGG:hsa04520 Adherens junction
- KEGG:hsa04613 Neutrophil extracellular trap formation
- KEGG:hsa04620 Toll-like receptor signaling pathway
- KEGG:hsa04621 NOD-like receptor signaling pathway
- KEGG:hsa04622 RIG-I-like receptor signaling pathway
- KEGG:hsa04657 IL-17 signaling pathway
- KEGG:hsa04660 T cell receptor signaling pathway
- KEGG:hsa04668 TNF signaling pathway
- KEGG:hsa04936 Alcoholic liver disease
- KEGG:hsa05130 Pathogenic Escherichia coli infection
- KEGG:hsa05131 Shigellosis
- KEGG:hsa05132 Salmonella infection
- KEGG:hsa05135 Yersinia infection
- KEGG:hsa05140 Leishmaniasis
- KEGG:hsa05145 Toxoplasmosis
- KEGG:hsa05161 Hepatitis B
- KEGG:hsa05162 Measles
- KEGG:hsa05168 Herpes simplex virus 1 infection
- KEGG:hsa05169 Epstein-Barr virus infection
- KEGG:hsa05170 Human immunodeficiency virus 1 infection
- KEGG:hsa05171 Coronavirus disease
- KEGG:hsa05417 Lipid and atherosclerosis
- KEGG:hsa05418 Fluid shear stress and atherosclerosis
Reactome
- R-hsa-450302 activated tak1 mediates p38 mapk activation
- R-hsa-1169091 activation of nf kappab in b cells
- R-hsa-1280218 adaptive immune system
- R-hsa-9645460 alpha protein kinase 1 signaling pathway
- R-hsa-3858494 beta catenin independent wnt signaling
- R-hsa-4086398 ca2 pathway
- R-hsa-5607764 clec7a dectin 1 signaling
- R-hsa-1280215 cytokine signaling in immune system
- R-hsa-5621481 c type lectin receptors clrs
- R-hsa-73887 death receptor signaling
- R-hsa-5688426 deubiquitination
- R-hsa-1168372 downstream signaling events of b cell receptor bcr
- R-hsa-202424 downstream tcr signaling
- R-hsa-2871837 fceri mediated nf kb activation
- R-hsa-2454202 fc epsilon receptor fceri signaling
- R-hsa-5663205 infectious disease
- R-hsa-168249 innate immune system
- R-hsa-448424 interleukin 17 signaling
- R-hsa-446652 interleukin 1 family signaling
- R-hsa-9020702 interleukin 1 signaling
- R-hsa-937042 irak2 mediated activation of tak1 complex
- R-hsa-450321 jnk c jun kinases phosphorylation and activation mediated by activated human tak1
- R-hsa-166166 myd88 independent tlr4 cascade
- R-hsa-168638 nod1 2 signaling pathway
- R-hsa-168643 nucleotide binding domain leucine rich repeat containing receptor nlr signaling pathways
- R-hsa-597592 post translational protein modification
- R-hsa-9705671 sars cov 2 activates modulates innate and adaptive immune responses
- R-hsa-9705683 sars cov 2 host interactions
- R-hsa-9694516 sars cov 2 infection
- R-hsa-9679506 sars cov infections
- R-hsa-449147 signaling by interleukins
- R-hsa-983705 signaling by the b cell receptor bcr
- R-hsa-195721 signaling by wnt
- R-hsa-445989 tak1 dependent ikk and nf kappa b activation
- R-hsa-202403 tcr signaling
- R-hsa-9014325 ticam1 traf6 dependent induction of tak1 complex
- R-hsa-5357956 tnfr1 induced nf kappa b signaling pathway
- R-hsa-75893 tnf signaling
- R-hsa-168138 toll like receptor 9 tlr9 cascade
- R-hsa-168898 toll like receptor cascades
- R-hsa-168179 toll like receptor tlr1 tlr2 cascade
- R-hsa-937072 traf6 mediated induction of tak1 complex within tlr4 complex
- R-hsa-5689880 ub specific processing proteases
- R-hsa-9824446 viral infection pathways
Canonical Pathways
- M236 Pid delta np63 pathway
- M19 Pid p73pathway
Mediation Categories
Clinical-translation mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
20 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| MAP3K7 | PPP6C | O00743 | T | 187 | dephosphorylation | SIGNORDEPOD | DEPOD:17079228SIGNOR:17079228 |
| MAP3K7 | PPP6C | O00743 | T | 187 | phosphorylation | SIGNOR_ProtMapperProtMapper | ProtMapper:17079228 |
| MAP3K7 | TRAF2 | Q12933 | K | 158 | ubiquitination | SIGNOR | SIGNOR:20038579 |
| MAP3K7 | TRAF6 | Q9Y4K3 | K | 34 | ubiquitination | SIGNOR | SIGNOR:18758450 |
| MAP3K7 | TRIM8 | Q9BZR9 | K | 158 | polyubiquitination | SIGNOR | SIGNOR:22084099 |
| MAP3K7 | PPP2CA | P67775 | T | 187 | dephosphorylation | SIGNORDEPOD | DEPOD:17079228SIGNOR:17079228 |
| MAP3K7 | PPP2CA | P67775 | T | 187 | phosphorylation | SIGNOR_ProtMapperProtMapper | ProtMapper:17079228 |
| MAP3K7 | PPP2CB | P62714 | T | 187 | dephosphorylation | DEPOD | DEPOD:17079228 |
| MAP3K7 | PPM1B | O75688 | S | 192 | dephosphorylation | DEPOD | DEPOD:11104763 |
| MAP3K7 | IL1B | P01584 | T | 187 | phosphorylation | REACH_ProtMapperSparser_ProtMapperProtMapper | ProtMapper:23646170ProtMapper:28507161 |
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Ligand-Receptor Signaling
9 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | No | Yes | No | No | No |
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
| receptor | receptor | scConnect | No | Yes | No | No | No |
Regulatory Interaction Network
52 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| RIPK1 | Q13546 | M3K7 | O43318 | Yes | Yes | No | InnateDBWangSIGNOR | InnateDB:18570872SIGNOR:21133840 |
| M3K7 | O43318 | RASF9 | O75901 | Yes | Yes | No | REACH_ProtMapperSIGNORSparser_ProtMapperProtMapper | SIGNOR:33717835ProtMapper:33717835 |
| M3K7 | O43318 | RIPK3 | Q9Y572 | Yes | Yes | No | WangSIGNOR | SIGNOR:24535827 |
| PINK1 | Q9BXM7 | M3K7 | O43318 | Yes | Yes | No | SIGNOR | SIGNOR:22643835 |
| M3K7 | O43318 | STING | Q86WV6 | Yes | Yes | No | SIGNOR | SIGNOR:37832545 |
| ILRL1 | Q01638 | M3K7 | O43318 | Yes | Yes | No | SIGNOR | SIGNOR:35238669 |
| M3K7 | O43318 | KSR1 | Q8IVT5 | Yes | No | Yes | iPTMnetSIGNORProtMapperSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | SIGNOR:11741534PhosphoSite:12941695ProtMapper:11741534 |
| M3K7 | O43318 | RAB1A | P62820 | Yes | Yes | No | PhosphoSite_norefSIGNORPhosphoSite_ProtMapperProtMapper | SIGNOR:27482120 |
| M3K7 | O43318 | PTN3 | P26045 | Yes | No | No | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetSIGNORProtMapperPhosphoSite_KEAKEAKinexus_KEASIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | KEA:9341175SIGNOR:9341175ProtMapper:9341175PhosphoSite:9341175 |
| M3K7 | O43318 | TP8L2 | Q6P589 | Yes | No | Yes | SIGNORPhosphoSitePhosphoSite_ProtMapperProtMapper | SIGNOR:32188758PhosphoSite:32188758 |
Protein Complex Composition
12 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| STAT3-NLK-MAP3K7 complex | MAP3K7NLKSTAT3 | O43318P40763Q9UBE8 | 1:1:1 | CompleatCORUM | CORUM:1520Compleat:HC743 | 15764709 |
| TAK1 complex | MAP3K7TAB1TAB2 | O43318Q15750Q9NYJ8 | 1:1:1 | CORUMCompleatComplexPortal | PDB:5E7RCompleat:HC693PDB:8GW3PDB:4L3PPDB:4L53intact:EBI-59035723PDB:7NTIPDB:5JK3PDB:5JGDPDB:4O91PDB:5JGBPDB:5GJFPDB:5GJGPDB:5V5NPDB:5JGAPDB:5J9LCORUM:2758PDB:5JH6PDB:4L52PDB:5J8IPDB:5J7SPDB:7NTH | 114601672215812214755292162891173346945817158449 |
| TAK1-TAB complexTAB3 variant | MAP3K7TAB1TAB3 | O43318Q15750Q8N5C8 | 1:1:1 | ComplexPortal | PDB:5E7RPDB:8GW3PDB:4L3PPDB:4L53PDB:7NTIPDB:5JK3PDB:5JGDPDB:4O91PDB:5JGBPDB:5GJFintact:EBI-59035885PDB:5GJGPDB:5V5NPDB:5JGAPDB:5J9LPDB:5JH6PDB:4L52PDB:5J8IPDB:5J7SPDB:7NTH | 114601672215812214755292162891173346945817158449 |
| TRAF6-TAK1 complex | MAP3K7TRAF6 | O43318Q9Y4K3 | 1:1 | CompleatCORUM | Compleat:HC3225CORUM:748 | 16543409 |
| CEP57EMILIN1MAP3K7PPFIA3TAB1TAB2TAB3TAX1BP1UBOX5 | O43318O75145O94941Q15750Q86VP1Q86XR8Q8N5C8Q9NYJ8Q9Y6C2 | 0:0:0:0:0:0:0:0:0 | hu.MAP2 | |||
| MAP3K7POLEPOLE2POLE3POLE4 | O43318P56282Q07864Q9NR33Q9NRF9 | 0:0:0:0:0 | Havugimana2012 | Havugimana2012:C_422 | ||
| MAP3K7TAB2TRAF2TRAF6 | O43318Q12933Q9NYJ8Q9Y4K3 | 0:0:0:0 | KEGG-MEDICUS | |||
| MAP3K7TAB1 | O43318Q15750 | 0:0 | KEGG-MEDICUS | |||
| MAP3K7TAB1TRAF6 | O43318Q15750Q9Y4K3 | 0:0:0 | KEGG-MEDICUS | |||
| MAP3K7TAB3 | O43318Q8N5C8 | 0:0 | KEGG-MEDICUS |
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Sequence, Structure & Domains
Sequences
Length
606
Mass
67,196
Sequence
MSTASAASSSSSSSAGEMIEAPSQVLNFEEIDYKEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESERKAFIVELRQLSRVNHPNIVKLYGACLNPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQTHMTNNKGSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGTRPPLIKNLPKPIESLMTRCWSKDPSQRPSMEEIVKIMTHLMRYFPGADEPLQYPCQYSDEGQSNSATSTGSFMDIASTNTSNKSDTNMEQVPATNDTIKRLESKLLKNQAKQQSESGRLSLGASRGSSVESLPPTSEGKRMSADMSEIEARIAATTAYSKPKRGHRKTASFGNILDVPEIVISGNGQPRRRSIQDLTVTGTEPGQVSSRSSSPSVRMITTSGPTSEKPTRSHPWTPDDSTDTNGSDNSIPMAYLTLDHQLQPLAPCPNSKESMAVFEQHCKMAQEYMKVQTEIALLLQRKQELVAELDQDEKDQQNTSRLVQEHKKLLDENKSLSTYYQQCKKQLEVIRSQQQKRQGTS
Alternative Products
Event=Alternative splicing; Named isoforms=4; Name=1B; IsoId=O43318-1; Sequence=Displayed; Name=1A; IsoId=O43318-2; Sequence=VSP_004886; Name=1C; IsoId=O43318-3; Sequence=VSP_004887, VSP_004888; Name=1D; IsoId=O43318-4; Sequence=VSP_004886, VSP_004887, VSP_004888
Alternative Sequence
404..430; Missing (in isoform 1A and isoform 1D); 509..518; PLAPCPNSKE -> ARTSCRTGPG (in isoform 1C and isoform 1D); 519..606; Missing (in isoform 1C and isoform 1D)
3D Structural Models
Turn
97..100; 166..169; 228..231; 292..295
Helix
33..35; 68..70; 71..83; 112..117; 127..145; 159..161; 182..186; 193..195; 198..201; 209..224; 236..244; 257..266; 271..273; 277..288
Beta Strand
36..44; 46..57; 59..64; 92..96; 101..105; 108..111; 118..123; 148..150; 162..165; 170..173; 300..302
3D Structure
X-ray crystallography (24)
Domain & Motif Annotations
Compositional Bias
306..338; Polar residues; 361..375; Low complexity; 443..452; Polar residues; 453..463; Low complexity; 464..473; Polar residues
Domain (FT)
36..291; Protein kinase
Region
1..300; Interaction with MAPK8IP1; 301..338; Disordered; 354..391; Disordered; 443..493; Disordered
Protein Families
- Protein kinase superfamily
- STE Ser/Thr protein kinase family
- MAP kinase kinase kinase subfamily
Sequence Similarities
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
Clinical Relevance
Disease Involvement
Disease variant
Related Diseases
Biomarker
Investigative
Interaction Protein
ENSG00000055208ENSG00000100324ENSG00000104365ENSG00000105401ENSG00000119414ENSG00000121653ENSG00000150991ENSG00000157625ENSG00000168610ENSG00000175104ENSG00000213341
Interaction Count
11
Interaction Dataset
intact_biogrid_opencellintact_biogrid_opencell_bioplexintact_biogridintact_biogrid_bioplex