Protein detail
PROM1
Prominin-1 (Antigen AC133) (Prominin-like protein 1) (CD antigen CD133)
Entry name PROM1 | UniProt ID | EVMP confidence score 0.50 |
Supporting publications (n) 1 | Transmembrane count 5 | Protein classification CD markersDisease related genesHuman disease related genesPotential drug targetsPredicted intracellular proteinsPredicted membrane proteinsTransporters |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information13
Protein Names
Prominin-1 (Antigen AC133) (Prominin-like protein 1) (CD antigen CD133)
Protein Class (7)
CD markersDisease related genesHuman disease related genesPotential drug targetsPredicted intracellular proteinsPredicted membrane proteinsTransporters
Protein Function (6)
- Transporters
- Predicted intracellular proteins
- CD markers
- Potential drug targets
- Disease related genes
- Human disease related genes:Nervous system diseases:Eye disease
Transmembrane
109..129; Helical; 158..178; Helical; 434..454; Helical; 487..507; Helical; 793..813; Helical
Transmembrane Count
5
Ensembl
Entrez Gene Symbol
Gene Synonym (7)
AC133CD133CORD12MCDR2PROML1RP41STGD4
Gene Description
Prominin 1
Chromosome
4
Position
15963076-16084378
Supporting publications (n)
1
EVMP confidence score
0.50
Fluorescence & Localization1
Function & Pathway7
Protein Function (6)
- Transporters
- Predicted intracellular proteins
- CD markers
- Potential drug targets
- Disease related genes
- Human disease related genes:Nervous system diseases:Eye disease
Cellular Component (14)
- GO:0001750 photoreceptor outer segment
- GO:0005615 extracellular space
- GO:0005783 endoplasmic reticulum
- GO:0005793 endoplasmic reticulum-Golgi intermediate compartment
- GO:0005886 plasma membrane
- GO:0005902 microvillus
- GO:0005929 cilium
- GO:0009986 cell surface
- GO:0016324 apical plasma membrane
- GO:0031528 microvillus membrane
Page 1 of 2
Molecular Function (4)
Biological Process (3)
Reactome (3)
Mediation Categories (2)
Clinical-translation mediationFusion and delivery mediation
Relations & Evidence30
Enzyme-Mediated Modification (4)
4 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| PROM1 | SRC | P12931 | Y | 852 | phosphorylation | PhosphoSite_MIMPMIMPSIGNORProtMapperSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | SIGNOR:19296573ProtMapper:19296573 |
| PROM1 | SRC | P12931 | Y | 828 | phosphorylation | PhosphoSite_MIMPMIMPSIGNORProtMapperSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | SIGNOR:19296573ProtMapper:19296573 |
| PROM1 | FYN | P06241 | Y | 828 | phosphorylation | PhosphoSite_MIMPMIMPProtMapperPhosphoSitePhosphoSite_ProtMapper | |
| PROM1 | FYN | P06241 | Y | 852 | phosphorylation | PhosphoSite_MIMPMIMPProtMapperPhosphoSitePhosphoSite_ProtMapper |
Ligand-Receptor Signaling (22)
22 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| cell_surface | cell_surface | OmniPath | No | No | No | Yes | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | No | Yes | No |
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Regulatory Interaction Network (3)
3 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| PTPRK | Q15262 | PROM1 | O43490 | Yes | No | Yes | SIGNOR | SIGNOR:30947381 |
| SRC | P12931 | PROM1 | O43490 | Yes | No | No | PhosphoSite_MIMPMIMPiPTMnetSIGNORProtMapperSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | PhosphoSite:26029999SIGNOR:19296573ProtMapper:19296573PhosphoSite:32201384 |
| FYN | P06241 | PROM1 | O43490 | Yes | No | No | PhosphoSite_MIMPMIMPiPTMnetProtMapperPhosphoSitePhosphoSite_ProtMapper | PhosphoSite:19296573 |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass spectrometryWestern blotting | 1 | 38716512 |
Sequence, Structure & Domains7
Sequences
Length
865
Mass
97,202
Sequence
MALVLGSLLLLGLCGNSFSGGQPSSTDAPKAWNYELPATNYETQDSHKAGPIGILFELVHIFLYVVQPRDFPEDTLRKFLQKAYESKIDYDKPETVILGLKIVYYEAGIILCCVLGLLFIILMPLVGYFFCMCRCCNKCGGEMHQRQKENGPFLRKCFAISLLVICIIISIGIFYGFVANHQVRTRIKRSRKLADSNFKDLRTLLNETPEQIKYILAQYNTTKDKAFTDLNSINSVLGGGILDRLRPNIIPVLDEIKSMATAIKETKEALENMNSTLKSLHQQSTQLSSSLTSVKTSLRSSLNDPLCLVHPSSETCNSIRLSLSQLNSNPELRQLPPVDAELDNVNNVLRTDLDGLVQQGYQSLNDIPDRVQRQTTTVVAGIKRVLNSIGSDIDNVTQRLPIQDILSAFSVYVNNTESYIHRNLPTLEEYDSYWWLGGLVICSLLTLIVIFYYLGLLCGVCGYDRHATPTTRGCVSNTGGVFLMVGVGLSFLFCWILMIIVVLTFVFGANVEKLICEPYTSKELFRVLDTPYLLNEDWEYYLSGKLFNKSKMKLTFEQVYSDCKKNRGTYGTLHLQNSFNISEHLNINEHTGSISSELESLKVNLNIFLLGAAGRKNLQDFAACGIDRMNYDSYLAQTGKSPAGVNLLSFAYDLEAKANSLPPGNLRNSLKRDAQTIKTIHQQRVLPIEQSLSTLYQSVKILQRTGNGLLERVTRILASLDFAQNFITNNTSSVIIEETKKYGRTIIGYFEHYLQWIEFSISEKVASCKPVATALDTAVDVFLCSYIIDPLNLFWFGIGKATVFLLPALIFAVKLAKYYRRMDSEDVYDDVETIPMKNMENGNNGYHKDHVYGIHNPVMTSPSQH
Alternative Products
Event=Alternative splicing; Named isoforms=7; Name=1; Synonyms=AC133-1, S2; IsoId=O43490-1; Sequence=Displayed; Name=2; Synonyms=AC133-2, S1; IsoId=O43490-2; Sequence=VSP_039069; Name=3; Synonyms=S3; IsoId=O43490-3; Sequence=VSP_040000, VSP_040002, VSP_040004; Name=4; Synonyms=S10; IsoId=O43490-4; Sequence=VSP_040000, VSP_040003; Name=5; Synonyms=S7; IsoId=O43490-5; Sequence=VSP_040000, VSP_040001; Name=6; Synonyms=S11; IsoId=O43490-6; Sequence=VSP_040001; Name=7; Synonyms=S12; IsoId=O43490-7; Sequence=VSP_040003
Alternative Sequence
92..100; Missing (in isoform 2); 93..101; Missing (in isoform 3, isoform 4 and isoform 5); 831..861; Missing (in isoform 5 and isoform 6); 831..839; VETIPMKNM -> SSWVTSVQC (in isoform 3); 839..861; Missing (in isoform 4 and isoform 7); 840..865; Missing (in isoform 3)
Domain & Motif Annotations
Protein Families
Prominin family
Sequence Similarities
Belongs to the prominin family.
Clinical Relevance8
Disease Involvement (4)
Cone-rod dystrophyDisease variantRetinitis pigmentosaStargardt disease
Related Diseases (7)
Biomarker
Preclinical; Phase 1
Drugs (2)
Interaction Protein
ENSG00000094631
Interaction Count
1
Interaction Dataset
intact_biogrid
Supporting Publications1
| PMID | Title | Abstract |
|---|---|---|
| 33919183 | Multiple-Cycle Polymeric Extracellular Vesicle Precipitation and Its Evaluation by Targeted Mass Spectrometry. | No abstract available |