Protein detail
S26A4
Pendrin (Sodium-independent chloride/iodide transporter) (Solute carrier family 26 member 4)
Entry name S26A4 | UniProt ID | EVMP confidence score 0.38 |
Supporting publications (n) | Transmembrane count 12 | Protein classification Disease related genesHuman disease related genesMetabolic proteinsPotential drug targetsPredicted membrane proteinsTransporters |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information12
Protein Names
Pendrin (Sodium-independent chloride/iodide transporter) (Solute carrier family 26 member 4)
Protein Class (6)
Disease related genesHuman disease related genesMetabolic proteinsPotential drug targetsPredicted membrane proteinsTransporters
Protein Function (5)
- Human disease related genes:Endocrine and metabolic diseases:Thyroid gland diseases
- Potential drug targets
- Transporters:Electrochemical Potential-driven transporters
- Disease related genes
- Human disease related genes:Nervous system diseases:Ear disease
Transmembrane
88..108; Helical; 110..130; Helical; 136..156; Helical; 192..212; Helical; 219..239; Helical; 264..284; Helical; 296..316; Helical; 345..365; Helical; 385..405; Helical; 422..442; Helical; 449..469; Helical; 487..507; Helical
Transmembrane Count
12
Ensembl
Entrez Gene Symbol
Gene Synonym (2)
DFNB4PDS
Gene Description
Solute carrier family 26 member 4
Chromosome
7
Position
107660828-107717809
EVMP confidence score
0.38
Function & Pathway8
Protein Function (5)
- Human disease related genes:Endocrine and metabolic diseases:Thyroid gland diseases
- Potential drug targets
- Transporters:Electrochemical Potential-driven transporters
- Disease related genes
- Human disease related genes:Nervous system diseases:Ear disease
Cellular Component (5)
Molecular Function (8)
- GO:0005515 protein binding
- GO:0008271 secondary active sulfate transmembrane transporter activity
- GO:0015106 bicarbonate transmembrane transporter activity
- GO:0015108 chloride transmembrane transporter activity
- GO:0015111 iodide transmembrane transporter activity
- GO:0015116 sulfate transmembrane transporter activity
- GO:0019531 oxalate transmembrane transporter activity
- GO:0140900 chloride:bicarbonate antiporter activity
Biological Process (3)
Reactome (6)
Canonical Pathways (3)
- M3008 Naba ecm glycoproteins
- M5884 Naba core matrisome
- M5889 Naba matrisome
Mediation Categories (2)
Clinical-translation mediationFusion and delivery mediation
Relations & Evidence24
Enzyme-Mediated Modification (1)
1 record.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| SLC26A4 | PRKACA | P17612 | T | 717 | phosphorylation | PhosphoSite |
Ligand-Receptor Signaling (20)
20 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane | transmembrane | LOCATE | No | No | No | No | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | No | No | No |
| transmembrane | transmembrane | OmniPath | No | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| apical_cell_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
| cell_surface | cell_surface | Surfaceome | No | No | No | No | No |
| cell_surface | cell_surface | OmniPath | No | No | No | No | No |
| receptor | receptor | scConnect | No | Yes | No | No | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | No | No | No |
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Regulatory Interaction Network (2)
2 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| RNF5 | Q99942 | S26A4 | O43511 | Yes | No | Yes | SIGNOR | SIGNOR:22750442 |
| KAPCA | P17612 | S26A4 | O43511 | Yes | No | No | PhosphoSitePhosphoSite_ProtMapperProtMapper | PhosphoSite:22109890 |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometry | 1 | 31753726 |
Sequence, Structure & Domains8
Sequences
Length
780
Mass
85,723
Sequence
MAAPGGRSEPPQLPEYSCSYMVSRPVYSELAFQQQHERRLQERKTLRESLAKCCSCSRKRAFGVLKTLVPILEWLPKYRVKEWLLSDVISGVSTGLVATLQGMAYALLAAVPVGYGLYSAFFPILTYFIFGTSRHISVGPFPVVSLMVGSVVLSMAPDEHFLVSSSNGTVLNTTMIDTAARDTARVLIASALTLLVGIIQLIFGGLQIGFIVRYLADPLVGGFTTAAAFQVLVSQLKIVLNVSTKNYNGVLSIIYTLVEIFQNIGDTNLADFTAGLLTIVVCMAVKELNDRFRHKIPVPIPIEVIVTIIATAISYGANLEKNYNAGIVKSIPRGFLPPELPPVSLFSEMLAASFSIAVVAYAIAVSVGKVYATKYDYTIDGNQEFIAFGISNIFSGFFSCFVATTALSRTAVQESTGGKTQVAGIISAAIVMIAILALGKLLEPLQKSVLAAVVIANLKGMFMQLCDIPRLWRQNKIDAVIWVFTCIVSIILGLDLGLLAGLIFGLLTVVLRVQFPSWNGLGSIPSTDIYKSTKNYKNIEEPQGVKILRFSSPIFYGNVDGFKKCIKSTVGFDAIRVYNKRLKALRKIQKLIKSGQLRATKNGIISDAVSTNNAFEPDEDIEDLEELDIPTKEIEIQVDWNSELPVKVNVPKVPIHSLVLDCGAISFLDVVGVRSLRVIVKEFQRIDVNVYFASLQDYVIEKLEQCGFFDDNIRKDTFFLTVHDAILYLQNQVKSQEGQGSILETITLIQDCKDTLELIETELTEEELDVQDEAMRTLAS
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O43511-1; Sequence=Displayed; Name=2; IsoId=O43511-2; Sequence=VSP_056688
Alternative Sequence
1..431; Missing (in isoform 2)
Domain & Motif Annotations
Domain (FT)
535..729; STAS
Protein Families
SLC26A/SulP transporter (TC 2.A.53) family
Sequence Similarities
Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
Clinical Relevance2
Disease Involvement (3)
DeafnessDisease variantNon-syndromic deafness
Antibody