Protein detail
AT8B1
Phospholipid-transporting ATPase IC (EC 7.6.2.1) (ATPase class I type 8B member 1) (Familial intrahepatic cholestasis type 1) (P4-ATPase flippase complex alpha subunit ATP8B1)
Entry name AT8B1 | UniProt ID | EVMP confidence score 0.40 |
Supporting publications (n) 1 | Transmembrane count 10 | Protein classification Disease related genesEnzymesHuman disease related genesMetabolic proteinsPotential drug targetsPredicted intracellular proteinsPredicted membrane proteinsTransporters |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Phospholipid-transporting ATPase IC (EC 7.6.2.1) (ATPase class I type 8B member 1) (Familial intrahepatic cholestasis type 1) (P4-ATPase flippase complex alpha subunit ATP8B1)
Protein Class (8)
Disease related genesEnzymesHuman disease related genesMetabolic proteinsPotential drug targetsPredicted intracellular proteinsPredicted membrane proteinsTransporters
Protein Function (7)
- Predicted intracellular proteins
- Human disease related genes:Digestive system diseases:Liver diseases
- Potential drug targets
- Enzymes
- ENZYME proteins
- Transporters:Primary Active Transporters
- Disease related genes
Transmembrane
109..130; Helical; 137..156; Helical; 341..362; Helical; 390..411; Helical; 950..970; Helical; 983..1002; Helical; 1033..1054; Helical; 1069..1091; Helical; 1098..1118; Helical; 1139..1163; Helical
Transmembrane Count
10
Ensembl
Entrez Gene Symbol
Gene Synonym (5)
ATPICBRICFIC1PFICPFIC1
Gene Description
ATPase phospholipid transporting 8B1
Chromosome
18
Position
57646426-57803315
Supporting publications (n)
1
EVMP confidence score
0.40
Fluorescence & Localization
Tissue Specificblood vesselCell SpecificBrain excitatory neuronsSingle-Nuclei Brain Specificdeep-layer near-projecting
Function & Pathway
Protein Function (7)
- Predicted intracellular proteins
- Human disease related genes:Digestive system diseases:Liver diseases
- Potential drug targets
- Enzymes
- ENZYME proteins
- Transporters:Primary Active Transporters
- Disease related genes
Cellular Component (10)
Molecular Function (10)
- GO:0000287 magnesium ion binding
- GO:0005515 protein binding
- GO:0005524 ATP binding
- GO:0016887 ATP hydrolysis activity
- GO:0090554 phosphatidylcholine floppase activity
- GO:0090556 phosphatidylserine floppase activity
- GO:0140326 ATPase-coupled intramembrane lipid transporter activity
- GO:0140345 phosphatidylcholine flippase activity
- GO:0140346 phosphatidylserine flippase activity
- GO:1901612 cardiolipin binding
Biological Process (3)
Reactome (3)
Canonical Pathways (3)
- M3008 Naba ecm glycoproteins
- M5884 Naba core matrisome
- M5889 Naba matrisome
Mediation Categories (2)
Clinical-translation mediationFusion and delivery mediation
Relations & Evidence16
Ligand-Receptor Signaling (15)
15 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| plasma_membrane | plasma_membrane | UniProt_location | |||||
| apical_cell_membrane | plasma_membrane | UniProt_location | |||||
| plasma_membrane | plasma_membrane | OmniPath | |||||
| receptor | receptor | scConnect | Yes | ||||
| transmembrane | transmembrane_predicted | Phobius |
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Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Mass spectrometry | 1 | 31753726 |
Sequence, Structure & Domains
Sequences
Length
1,251
Mass
143,695
Sequence
MSTERDSETTFDEDSQPNDEVVPYSDDETEDELDDQGSAVEPEQNRVNREAEENREPFRKECTWQVKANDRKYHEQPHFMNTKFLCIKESKYANNAIKTYKYNAFTFIPMNLFEQFKRAANLYFLALLILQAVPQISTLAWYTTLVPLLVVLGVTAIKDLVDDVARHKMDKEINNRTCEVIKDGRFKVAKWKEIQVGDVIRLKKNDFVPADILLLSSSEPNSLCYVETAELDGETNLKFKMSLEITDQYLQREDTLATFDGFIECEEPNNRLDKFTGTLFWRNTSFPLDADKILLRGCVIRNTDFCHGLVIFAGADTKIMKNSGKTRFKRTKIDYLMNYMVYTIFVVLILLSAGLAIGHAYWEAQVGNSSWYLYDGEDDTPSYRGFLIFWGYIIVLNTMVPISLYVSVEVIRLGQSHFINWDLQMYYAEKDTPAKARTTTLNEQLGQIHYIFSDKTGTLTQNIMTFKKCCINGQIYGDHRDASQHNHNKIEQVDFSWNTYADGKLAFYDHYLIEQIQSGKEPEVRQFFFLLAVCHTVMVDRTDGQLNYQAASPDEGALVNAARNFGFAFLARTQNTITISELGTERTYNVLAILDFNSDRKRMSIIVRTPEGNIKLYCKGADTVIYERLHRMNPTKQETQDALDIFANETLRTLCLCYKEIEEKEFTEWNKKFMAASVASTNRDEALDKVYEEIEKDLILLGATAIEDKLQDGVPETISKLAKADIKIWVLTGDKKETAENIGFACELLTEDTTICYGEDINSLLHARMENQRNRGGVYAKFAPPVQESFFPPGGNRALIITGSWLNEILLEKKTKRNKILKLKFPRTEEERRMRTQSKRRLEAKKEQRQKNFVDLACECSAVICCRVTPKQKAMVVDLVKRYKKAITLAIGDGANDVNMIKTAHIGVGISGQEGMQAVMSSDYSFAQFRYLQRLLLVHGRWSYIRMCKFLRYFFYKNFAFTLVHFWYSFFNGYSAQTAYEDWFITLYNVLYTSLPVLLMGLLDQDVSDKLSLRFPGLYIVGQRDLLFNYKRFFVSLLHGVLTSMILFFIPLGAYLQTVGQDGEAPSDYQSFAVTIASALVITVNFQIGLDTSYWTFVNAFSIFGSIALYFGIMFDFHSAGIHVLFPSAFQFTGTASNALRQPYIWLTIILAVAVCLLPVVAIRFLSMTIWPSESDKIQKHRKRLKAEEQWQRRQQVFRRGVSTRRSAYAFSHQRGYADLISSGRSIRKKRSPLDAIVADGTAEYRRTGDS
3D Structural Models
Turn
134..136; 229..231; 366..369; 428..431; 455..458; 598..600; 826..828; 831..833; 835..838; 912..914; 917..921; 970..973; 989..993; 1127..1129; 1181..1184; 1223..1226
Helix
73..75; 77..79; 108..115; 119..130; 142..173; 191..193; 220..222; 244..249; 253..258; 290..292; 314..316; 318..321; 332..365; 371..373; 381..395; 396..399; 404..421; 423..425; 443..446; 511..518; 522..533; 553..564; 622..626; 636..648; 663..677; 685..694; 714..723; 735..743; 745..748; 758..770; 793..796; 803..810; 840..858; 870..884; 895..897; 898..903; 929..931; 932..936; 939..962; 964..969; 982..988; 995..1003; 1009..1014; 1016..1019; 1020..1023; 1031..1056; 1069..1091; 1097..1118; 1120..1125; 1135..1139; 1143..1155; 1158..1170; 1174..1180; 1217..1222
Beta Strand
19..21; 64..67; 84..86; 90..92; 104..106; 177..181; 183..190; 199..203; 210..219; 223..227; 238..241; 250..252; 262..265; 277..281; 284..288; 299..312; 435..437; 439..441; 450..453; 460..471; 474..476; 486..488; 498..500; 538..540; 542..545; 547..549; 550..552; 568..572; 574..581; 584..593; 602..608; 610..612; 614..620; 655..658; 680..682; 697..710; 727..730; 753..756; 776..778; 797..802; 859..867; 888..892; 904..909; 922..924; 1027..1029; 1062..1064; 1093..1096; 1140..1142
3D Structure
Electron microscopy (13)
Domain & Motif Annotations
Compositional Bias
25..35; Acidic residues; 43..54; Basic and acidic residues
Region
1..54; Disordered
Protein Families (2)
- Cation transport ATPase (P-type) (TC 3.A.3) family
- Type IV subfamily
Sequence Similarities
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
Clinical Relevance
Disease Involvement (2)
Disease variantIntrahepatic cholestasis
Related Diseases
Drugs
Supporting Publications1
| PMID | Title | Related sentences |
|---|---|---|
| 28986585 | Quantitation of putative colorectal cancer biomarker candidates in serum extracellular vesicles by targeted proteomics. | No related sentences available |