Protein detail
SGCE
Epsilon-sarcoglycan (Epsilon-SG)
Protein symbol SGCE | UniProt ID | EVMP score 0.63 |
Frequency 10 | Transmembrane count 1 | Protein classification |
Basic Information
Protein Names
Epsilon-sarcoglycan (Epsilon-SG)
Protein Function
- Disease related genes
- Human disease related genes:Nervous system diseases:Other nervous and sensory system diseases
- Predicted intracellular proteins
Transmembrane
318..338; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Frequency
10
EVMP Score
0.63
Fluorescence & Localization
Tissue Specificskeletal muscleCell SpecificAdipocytesSecretome LocationIntracellular and membraneSecretome FunctionTransport
Function & Pathway
Protein Function
- Disease related genes
- Human disease related genes:Nervous system diseases:Other nervous and sensory system diseases
- Predicted intracellular proteins
Cellular Component
Biological Process
KEGG
Reactome
Mediation Categories
Adhesion and uptake mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
23 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | No | No | No | Yes | No |
| intracellular | intracellular | ComPPI | No | No | No | Yes | No |
| intracellular | intracellular | GO_Intercell | No | No | No | Yes | No |
| intracellular | intracellular | UniProt_location | No | No | No | Yes | No |
| intracellular | intracellular | OmniPath | No | No | No | Yes | No |
| matrix_adhesion | matrix_adhesion | Zhong2015 | No | Yes | No | Yes | No |
| adhesion | adhesion | OmniPath | Yes | Yes | No | Yes | No |
| matrix_adhesion | matrix_adhesion | OmniPath | No | Yes | No | Yes | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_topology | No | No | No | Yes | No |
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Regulatory Interaction Network
0 records.
Protein Complex Composition
0 records.
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometry | 1 | 31753726 |
Sequence, Structure & Domains
Sequences
Length
437
Mass
49,851
Sequence
MQLPRWWELGDPCAWTGQGRGTRRMSPATTGTFLLTVYSIFSKVHSDRNVYPSAGVLFVHVLEREYFKGEFPPYPKPGEISNDPITFNTNLMGYPDRPGWLRYIQRTPYSDGVLYGSPTAENVGKPTIIEITAYNRRTFETARHNLIINIMSAEDFPLPYQAEFFIKNMNVEEMLASEVLGDFLGAVKNVWQPERLNAINITSALDRGGRVPLPINDLKEGVYVMVGADVPFSSCLREVENPQNQLRCSQEMEPVITCDKKFRTQFYIDWCKISLVDKTKQVSTYQEVIRGEGILPDGGEYKPPSDSLKSRDYYTDFLITLAVPSAVALVLFLILAYIMCCRREGVEKRNMQTPDIQLVHHSAIQKSTKELRDMSKNREIAWPLSTLPVFHPVTGEIIPPLHTDNYDSTNMPLMQTQQNLPHQTQIPQQQTTGKWYP
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=epsilon-SG1; IsoId=O43556-1; Sequence=Displayed; Name=2; Synonyms=epsilon-SG2; IsoId=O43556-3; Sequence=VSP_045092, VSP_045093; Name=3; IsoId=O43556-4; Sequence=VSP_054079
Alternative Sequence
347..355; Missing (in isoform 2); 418; Q -> QWSFAPVAQAGVQWSDLGSLQPPPPR (in isoform 3); 434..437; KWYP -> DFRLTTFQRFEVNGIPEERKLTEAMNL (in isoform 2)
3D Structural Models
Domain & Motif Annotations
Protein Families
Sarcoglycan alpha/epsilon family
Sequence Similarities
Belongs to the sarcoglycan alpha/epsilon family.