Protein detail
SGCE
Epsilon-sarcoglycan (Epsilon-SG)
Entry name SGCE | UniProt ID | EVMP confidence score 0.63 |
Supporting publications (n) 10 | Transmembrane count 1 | Protein classification |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information8
Protein Names
Epsilon-sarcoglycan (Epsilon-SG)
Protein Function (3)
- Disease related genes
- Human disease related genes:Nervous system diseases:Other nervous and sensory system diseases
- Predicted intracellular proteins
Transmembrane
318..338; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Supporting publications (n)
10
EVMP confidence score
0.63
Fluorescence & Localization5
Tissue Specificskeletal muscleCell SpecificAdipocytesSecretome LocationIntracellular and membraneSecretome FunctionTransport
Function & Pathway6
Protein Function (3)
- Disease related genes
- Human disease related genes:Nervous system diseases:Other nervous and sensory system diseases
- Predicted intracellular proteins
Cellular Component (7)
Biological Process (3)
KEGG (5)
Reactome (3)
Mediation Categories
Adhesion and uptake mediation
Relations & Evidence24
Ligand-Receptor Signaling (23)
23 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | No | No | No | Yes | No |
| intracellular | intracellular | ComPPI | No | No | No | Yes | No |
| intracellular | intracellular | GO_Intercell | No | No | No | Yes | No |
| intracellular | intracellular | UniProt_location | No | No | No | Yes | No |
| intracellular | intracellular | OmniPath | No | No | No | Yes | No |
| matrix_adhesion | matrix_adhesion | Zhong2015 | No | Yes | No | Yes | No |
| adhesion | adhesion | OmniPath | Yes | Yes | No | Yes | No |
| matrix_adhesion | matrix_adhesion | OmniPath | No | Yes | No | Yes | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_topology | No | No | No | Yes | No |
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Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometry | 1 | 31753726 |
Sequence, Structure & Domains7
Sequences
Length
437
Mass
49,851
Sequence
MQLPRWWELGDPCAWTGQGRGTRRMSPATTGTFLLTVYSIFSKVHSDRNVYPSAGVLFVHVLEREYFKGEFPPYPKPGEISNDPITFNTNLMGYPDRPGWLRYIQRTPYSDGVLYGSPTAENVGKPTIIEITAYNRRTFETARHNLIINIMSAEDFPLPYQAEFFIKNMNVEEMLASEVLGDFLGAVKNVWQPERLNAINITSALDRGGRVPLPINDLKEGVYVMVGADVPFSSCLREVENPQNQLRCSQEMEPVITCDKKFRTQFYIDWCKISLVDKTKQVSTYQEVIRGEGILPDGGEYKPPSDSLKSRDYYTDFLITLAVPSAVALVLFLILAYIMCCRREGVEKRNMQTPDIQLVHHSAIQKSTKELRDMSKNREIAWPLSTLPVFHPVTGEIIPPLHTDNYDSTNMPLMQTQQNLPHQTQIPQQQTTGKWYP
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=epsilon-SG1; IsoId=O43556-1; Sequence=Displayed; Name=2; Synonyms=epsilon-SG2; IsoId=O43556-3; Sequence=VSP_045092, VSP_045093; Name=3; IsoId=O43556-4; Sequence=VSP_054079
Alternative Sequence
347..355; Missing (in isoform 2); 418; Q -> QWSFAPVAQAGVQWSDLGSLQPPPPR (in isoform 3); 434..437; KWYP -> DFRLTTFQRFEVNGIPEERKLTEAMNL (in isoform 2)
Domain & Motif Annotations
Protein Families
Sarcoglycan alpha/epsilon family
Sequence Similarities
Belongs to the sarcoglycan alpha/epsilon family.
Supporting Publications10
| PMID | Title | Abstract |
|---|---|---|
| 28242843 | Label-free Proteomic Analysis of Exosomes Derived from Inducible Hepatitis B Virus-Replicating HepAD38 Cell Line. | No abstract available |
| 31685984 | Tumour exosomal CEMIP protein promotes cancer cell colonization in brain metastasis. | Proteomic analysis identified cell migration-inducing and hyaluronan-binding protein (CEMIP) as elevated in exosomes from brain metastatic but not lung or bone metastatic cells. |
| 33718342 | Extracellular Vesicles Derived From Adult and Fetal Bone Marrow Mesenchymal Stromal Cells Differentially Promote ex vivo Expansion of Hematopoietic Stem and Progenitor Cells. | No abstract available |
| 37686366 | Identification of a Non-Invasive Urinary Exosomal Biomarker for Diabetic Nephropathy Using Data-Independent Acquisition Proteomics. | No abstract available |
| 38136601 | Identification of Central Nervous System Oncologic Disease Biomarkers in EVs from Cerebrospinal Fluid (CSF) of Pediatric Patients: A Pilot Neuro-Proteomic Study. | No abstract available |
| 38731868 | The Deep Proteomics Approach Identified Extracellular Vesicular Proteins Correlated to Extracellular Matrix in Type One and Two Endometrial Cancer. | No abstract available |
| 39949490 | CRISPR-dCas9 Activation of TSG-6 in MSCs Modulates the Cargo of MSC-Derived Extracellular Vesicles and Attenuates Inflammatory Responses in Human Intervertebral Disc Cells In Vitro. | No abstract available |
| 40311616 | Integrative proteomic profiling of tumor and plasma extracellular vesicles identifies a diagnostic biomarker panel for colorectal cancer. | No abstract available |
| 40619995 | A 96-Well Ultrafiltration Approach for the High-Throughput Proteome Analysis of Extracellular Vesicles Isolated From Conditioned Medium. | No abstract available |
| 41201090 | Identification of molecular markers and exploration of the oncogenic role of exomeres in hepatocellular carcinoma. | No abstract available |