Protein detail

LAT

Linker for activation of T-cells family member 1 (36 kDa phosphotyrosine adapter protein) (pp36) (p36-38)

Entry name LAT	UniProt ID O43561	EVMP confidence score 0.63
Supporting publications (n) 6	Transmembrane count 1	Protein classification Disease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteinsPredicted membrane proteinsRAS pathway related proteins

Basic Information

Protein Names

Linker for activation of T-cells family member 1 (36 kDa phosphotyrosine adapter protein) (pp36) (p36-38)

Protein Class (6)

Disease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteinsPredicted membrane proteinsRAS pathway related proteins

Protein Function (4)

Human disease related genes:Immune system diseases:Primary immunodeficiency
Disease related genes
Predicted intracellular proteins
RAS pathway related proteins

Transmembrane

5..27; Helical; Signal-anchor for type III membrane protein

Transmembrane Count

Ensembl

ENSG00000213658

Entrez Gene Symbol

LAT

Gene Synonym

LAT1

Gene Description

Linker for activation of T cells

Chromosome

Position

28984826-28990784

Supporting publications (n)

EVMP confidence score

0.63

Fluorescence & Localization

Function & Pathway

Protein Function (4)

Human disease related genes:Immune system diseases:Primary immunodeficiency
Disease related genes
Predicted intracellular proteins
RAS pathway related proteins

Cellular Component (8)

Molecular Function (4)

Biological Process (3)

KEGG (11)

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Reactome (14)

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Mediation Categories (4)

Clinical-translation mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation

Relations & Evidence166

Enzyme-Mediated Modification (60)

60 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
LAT	ZAP70	P43403	Y	207	phosphorylation	MIMPHPRDHPRD_MIMPPhosphoSite_MIMP	HPRD:11368773
LAT	ZAP70	P43403	Y	227	phosphorylation	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPHPRD	HPRD:11368773
LAT	ZAP70	P43403	Y	262	phosphorylation	MIMPHPRDHPRD_MIMPPhosphoSite_MIMP	HPRD:11368773
LAT	LCK	P06239	Y	220	phosphorylation	SIGNOR_ProtMapperReactome_ProtMapperSIGNORProtMapper	ProtMapper:16938345 SIGNOR:16938345
LAT	LCK	P06239	Y	200	phosphorylation	SIGNOR_ProtMapperReactome_ProtMapperSIGNORProtMapper	ProtMapper:16938345 SIGNOR:16938345
LAT	LCK	P06239	Y	156	phosphorylation	RLIMS-P_ProtMapperREACH_ProtMapperSparser_ProtMapperProtMapper	ProtMapper:27700984
LAT	LCK	P06239	Y	64	phosphorylation	RLIMS-P_ProtMapperREACH_ProtMapperSparser_ProtMapperProtMapper	ProtMapper:27700984
LAT	FYN	P06241	Y	220	phosphorylation	SIGNOR_ProtMapperSIGNORProtMapper	ProtMapper:16938345 SIGNOR:16938345
LAT	FYN	P06241	Y	200	phosphorylation	SIGNOR_ProtMapperSIGNORProtMapper	ProtMapper:16938345 SIGNOR:16938345
LAT	MAPK3	P27361	T	184	phosphorylation	SIGNOR_ProtMapperSIGNORProtMapper	ProtMapper:15192708 SIGNOR:15192708

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Ligand-Receptor Signaling (15)

15 records.

Category	Parent	Database	Receiver	Plasma Membrane (Transmembrane)
receptor	receptor	CellTalkDB	Yes	Yes
receptor	receptor	OmniPath	Yes	Yes
intracellular	intracellular	LOCATE		Yes
intracellular	intracellular	ComPPI		Yes
intracellular	intracellular	GO_Intercell		Yes
intracellular	intracellular	OmniPath		Yes
transmembrane	transmembrane	UniProt_location		Yes
transmembrane	transmembrane	UniProt_topology		Yes
transmembrane	transmembrane	UniProt_keyword		Yes
transmembrane	transmembrane	TopDB		Yes

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Regulatory Interaction Network (23)

23 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
PTPRJ	Q12913	LAT	O43561	Yes		Yes	WangSIGNORDEPODHPRDSPIKE_LCSPIKE	DEPOD:11259588 HPRD:11259588 SPIKE:11259588 SIGNOR:11259588 SPIKE_LC:11259588
LAT	O43561	PLCG1	P19174	Yes	Yes		WangNetPathSIGNORLi2012HPRDCui2007HINTSignaLink3BioGRIDIntActLMPIDSPIKE_LCLit-BM-17SPIKETCRcuration_SignaLink3	HINT:27221712 Lit-BM-17:11368773 IntAct:16938345 SignaLink3:23109003 SignaLink3:15286727 HPRD:9729044 SPIKE_LC:16467851 IntAct:9489702 NetPath:10811803 SignaLink3:11709089 SPIKE:10811803 SPIKE:16467851 Lit-BM-17:9489702 HINT:10811803 LMPID:10811803 SIGNOR:11368773 HINT:9489702 SignaLink3:15219999 SPIKE_LC:10811803 HINT:16938345 HINT:15696170 IntAct:24642916 SPIKE_LC:16938345 IntAct:10811803 HINT:16467851 Lit-BM-17:10811803 HINT:11368773 LMPID:11368773 HINT:24642916 HPRD:11368773 SignaLink3:12941616 SPIKE:16713569 Lit-BM-17:16938345 Lit-BM-17:27221712 BioGRID:9729044 SPIKE:16938345 Lit-BM-17:16467851 SPIKE_LC:16713569 HPRD:16467851
LAT	O43561	VAV	P15498	Yes	Yes		WangNetPathSIGNORHPRDHINTSignaLink3Li2012SPIKE_LCSPIKETCRcuration_SignaLink3	SPIKE:16713569 SignaLink3:23109003 NetPath:12186560 HINT:12186560 SPIKE_LC:12186560 HINT:11368773 SPIKE:12186560 SPIKE_LC:16713569 HPRD:11368773 SignaLink3:12186560 SIGNOR:11368773
LAT	O43561	GAB2	Q9UQC2	Yes			WangNetPathHPRDSignaLink3SPIKE_LCSPIKETCRcuration_SignaLink3	HPRD:11572860 SignaLink3:23109003 SignaLink3:12640133 NetPath:11572860 SignaLink3:11572860 SPIKE_LC:11572860 SPIKE:11572860
LAT	O43561	GRB2	P62993	Yes	Yes		WangNetPathSIGNORLi2012HPRDCui2007HINTBioGRIDIntActDIPSPIKE_LCLit-BM-17SPIKE	Lit-BM-17:12186560 Lit-BM-17:11368773 IntAct:16938345 NetPath:12186560 HINT:12186560 SIGNOR:23150273 HINT:7510700 NetPath:17043143 SIGNOR:10811803 IntAct:9489702 DIP:16906159 Lit-BM-17:16906159 HPRD:16906159 Lit-BM-17:9489702 HINT:10811803 HINT:16906159 HPRD:9489702 BioGRID:8063801 HINT:8063801 HINT:9489702 HINT:16938345 SPIKE_LC:16938345 IntAct:10811803 SPIKE_LC:12186560 Lit-BM-17:10811803 SPIKE:12186560 SPIKE:16906159 HINT:7516467 SPIKE:16713569 Lit-BM-17:16938345 Lit-BM-17:8063801 SPIKE_LC:16906159 SPIKE:16938345 IntAct:16906159 SPIKE_LC:16713569
LAT	O43561	VAV3	Q9UKW4	Yes			SignaLink3TCRcuration_SignaLink3	SignaLink3:23109003 SignaLink3:12186560
LAT	O43561		Q6FHA6	Yes			SignaLink3TCRcuration_SignaLink3	SignaLink3:10021361 SignaLink3:23109003 SignaLink3:15219999
ZAP70	P43403	LAT	O43561	Yes	Yes		HPRD_MIMPSIGNORProtMapperRLIMS-P_ProtMapperHINTPhosphoSite_KEASignaLink3phosphoELM_KEAHPRDWangphosphoELM_MIMPPhosphoSite_MIMPMIMPPhosphoSite_norefPhosphoPointiPTMnetKEAHPRD_KEASIGNOR_ProtMapperREACH_ProtMapperPhosphoSiteTCRcuration_SignaLink3Sparser_ProtMapperSPIKE_LCHPRD-phos	KEA:15659558 ProtMapper:11368773 PhosphoSite:11395491 SignaLink3:23109003 PhosphoSite:27896837 HINT:12186560 SIGNOR:29915297 KEA:10811803 ProtMapper:27700984 PhosphoSite:12496416 PhosphoSite:30510001 ProtMapper:24119664 PhosphoSite:24642916 ProtMapper:31611699 ProtMapper:29915297 PhosphoSite:15100278 ProtMapper:23758320 SIGNOR:11368773 KEA:11368773 ProtMapper:35095913 ProtMapper:18779373 HPRD-phos:11368773 PhosphoSite:11368773 ProtMapper:22507872 ProtMapper:23150273 HINT:11368773 HPRD:11368773 PhosphoSite:33931484 SPIKE_LC:16906159 PhosphoSite:15029250 PhosphoSite:24412752 SignaLink3:15084594 PhosphoSite:34161759
LAT	O43561	3BP2	P78314	Yes			HPRDHINTSignaLink3TCRcuration_SignaLink3	HINT:9846481 SignaLink3:23109003 HPRD:11390470 SignaLink3:15751964 HINT:17306257
LAT	O43561	P85A	P27986	Yes	Yes		WangNetPathSIGNORHINTSignaLink3SPIKE_LCTCRcuration_SignaLink3	SignaLink3:19132916 NetPath:9489702 SignaLink3:23109003 SignaLink3:14696041 HINT:10811803 HINT:11368773 SPIKE_LC:16713569 HINT:7544353 SIGNOR:11368773

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Protein Complex Composition (67)

67 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
DLAT DLD PDHA1 PDHB PDHX PDK1 PDK2 PDK3 PDK4 PITRM1 UBC	O00330 P08559 P09622 P0CG48 P10515 P11177 Q15118 Q15119 Q15120 Q16654 Q5JRX3	1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC4648
DLAT EIF6 PDHA1 PDHB PDHX PDK1 PDK2 PDK3 PDK4 PDP2 UBC	O00330 P08559 P0CG48 P10515 P11177 P56537 Q15118 Q15119 Q15120 Q16654 Q9P2J9	1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC5580
DLAT PDHA1 PDHB PDHX STAT5A STAT5B	O00330 P08559 P10515 P11177 P42229 P51692	0:0:0:0:0:0	hu.MAP
DLAT PDHA1 PDHB PDHX PDK3	O00330 P08559 P10515 P11177 Q15120	0:0:0:0:0	hu.MAP2
DLAT DLD DLST KGD4 OGDH OGDHL PDHX	O00330 P09622 P10515 P36957 P82909 Q02218 Q9ULD0	0:0:0:0:0:0:0	hu.MAP2
CCNA2 CCNB1 CCNB2 CCNE1 CDK1 CDK2 CDK3 CKS1B CKS2 LATS1 MAST4 UBC	O15021 O95067 O95835 P06493 P0CG48 P14635 P20248 P24864 P24941 P33552 P61024 Q00526	1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC7261
ASH2L CTBP1 CXXC1 DPY30 H3-4 H3C15 KMT2A KMT2B LCLAT1 RBBP5 SETD1A UBC WDR5 WDR82 ZDHHC9	O15047 P0CG48 P61964 Q03164 Q13363 Q15291 Q16695 Q6UWP7 Q6UXN9 Q71DI3 Q9C005 Q9P0U4 Q9UBL3 Q9UMN6 Q9Y397	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC6728
ABL1 H4C4 HNRNPR LATS1 LATS2 MOB1B	O43390 O95835 P00519 P62805 Q7L9L4 Q9NRM7	1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC7692
ABL1 HNRNPR LATS1 LATS2 MOB1B SAV1 STK3	O43390 O95835 P00519 Q13188 Q7L9L4 Q9H4B6 Q9NRM7	1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC9490
GRAP2 LAT LCP2 VAV1	O43561 O75791 P15498 Q13094	0:0:0:0	KEGG-MEDICUS

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Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	2	31753726 29603567

Sequence, Structure & Domains

Sequences

Length

262

Mass

27,930

Sequence

MEEAILVPCVLGLLLLPILAMLMALCVHCHRLPGSYDSTSSDSLYPRGIQFKRPHTVAPWPPAYPPVTSYPPLSQPDLLPIPRSPQPLGGSHRTPSSRRDSDGANSVASYENEGASGIRGAQAGWGVWGPSWTRLTPVSLPPEPACEDADEDEDDYHNPGYLVVLPDSTPATSTAAPSAPALSTPGIRDSAFSMESIDDYVNVPESGESAEASLDGSREYVNVSQELHPGAAKTEPAALSSQEAEEVEEEGAPDYENLQELN

Alternative Products

Event=Alternative splicing; Named isoforms=5; Name=1; Synonyms=Long; IsoId=O43561-1; Sequence=Displayed; Name=2; Synonyms=Short; IsoId=O43561-2; Sequence=VSP_004303; Name=3; IsoId=O43561-3; Sequence=VSP_054758, VSP_004303; Name=4; IsoId=O43561-4; Sequence=VSP_054759, VSP_004303; Name=5; IsoId=O43561-5; Sequence=VSP_054759

Alternative Sequence

1; M -> MEATAASWQVAVPVLGGASRPLGPRGAASLLRAPLQM (in isoform 3); 83; Missing (in isoform 4 and isoform 5); 114..142; Missing (in isoform 2, isoform 3 and isoform 4)

Domain & Motif Annotations

Compositional Bias

243..253; Acidic residues

Region

69..115; Disordered; 161..164; Interaction with PLCG1; 200..203; Interaction with GRB2, GRAP2 and PIK3R1; 206..262; Disordered; 220..223; Interaction with GRB2, GRAP2 and PIK3R1

Clinical Relevance

Drug Targets

Literature-reported target

Drugs

TRIDOLGOSIR

Antibody (4)

CAB002223 HPA011157 CAB012978 CAB079960

Interaction Protein (5)

ENSG00000124181ENSG00000146648ENSG00000177885ENSG00000182866ENSG00000196396

Interaction Count

Interaction Dataset

intact_biogrid

Supporting Publications6

PMID	Title	Related sentences
27821849	Detailed Analysis of Protein Topology of Extracellular Vesicles-Evidence of Unconventional Membrane Protein Orientation.	No related sentences available
32230970	Radiation Exposure of Peripheral Mononuclear Blood Cells Alters the Composition and Function of Secreted Extracellular Vesicles.	No related sentences available
36736734	Extracellular vesicle proteomics and phosphoproteomics identify pathways for increased risk in patients hospitalized with COVID-19 and type 2 diabetes mellitus.	No related sentences available
37322475	Comprehensive profiling of extracellular vesicles in uveitis and scleritis enables biomarker discovery and mechanism exploration.	No related sentences available
38014595	Proteome and immune responses of extracellular vesicles derived from macrophages infected with the periodontal pathogen Tannerella forsythia.	No related sentences available
40465195	Extracellular vesicle proteomics uncovers energy metabolism, complement system, and endoplasmic reticulum stress response dysregulation postexercise in males with myalgic encephalomyelitis/chronic fatigue syndrome.	No related sentences available