Protein detail
LAT
Linker for activation of T-cells family member 1 (36 kDa phosphotyrosine adapter protein) (pp36) (p36-38)
Entry name LAT | UniProt ID | EVMP confidence score 0.63 |
Supporting publications (n) 6 | Transmembrane count 1 | Protein classification Disease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteinsPredicted membrane proteinsRAS pathway related proteins |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Linker for activation of T-cells family member 1 (36 kDa phosphotyrosine adapter protein) (pp36) (p36-38)
Protein Class (6)
Disease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteinsPredicted membrane proteinsRAS pathway related proteins
Protein Function (4)
- Human disease related genes:Immune system diseases:Primary immunodeficiency
- Disease related genes
- Predicted intracellular proteins
- RAS pathway related proteins
Transmembrane
5..27; Helical; Signal-anchor for type III membrane protein
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
LAT1
Gene Description
Linker for activation of T cells
Chromosome
16
Position
28984826-28990784
Supporting publications (n)
6
EVMP confidence score
0.63
Fluorescence & Localization
Function & Pathway
Protein Function (4)
- Human disease related genes:Immune system diseases:Primary immunodeficiency
- Disease related genes
- Predicted intracellular proteins
- RAS pathway related proteins
Cellular Component (8)
Molecular Function (4)
Biological Process (3)
KEGG (11)
- hsa04014 Ras signaling pathway
- KEGG:hsa04015 Rap1 signaling pathway
- KEGG:hsa04064 NF-kappa B signaling pathway
- KEGG:hsa04650 Natural killer cell mediated cytotoxicity
- KEGG:hsa04658 Th1 and Th2 cell differentiation
- KEGG:hsa04659 Th17 cell differentiation
- KEGG:hsa04660 T cell receptor signaling pathway
- KEGG:hsa04664 Fc epsilon RI signaling pathway
- KEGG:hsa04666 Fc gamma R-mediated phagosome formation
- KEGG:hsa05135 Yersinia infection
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Reactome (14)
- R-hsa-1280218 adaptive immune system
- R-hsa-2172127 dap12 interactions
- R-hsa-2424491 dap12 signaling
- R-hsa-2871809 fceri mediated ca 2 mobilization
- R-hsa-2871796 fceri mediated mapk activation
- R-hsa-2454202 fc epsilon receptor fceri signaling
- R-hsa-202433 generation of second messenger molecules
- R-hsa-114604 gpvi mediated activation cascade
- R-hsa-109582 hemostasis
- R-hsa-168249 innate immune system
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Mediation Categories (4)
Clinical-translation mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation
Relations & Evidence166
Enzyme-Mediated Modification (60)
60 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| LAT | ZAP70 | P43403 | Y | 171 | phosphorylation | HPRDPhosphoSiteKEA | HPRD:11368773KEA:11368773 |
| LAT | ZAP70 | P43403 | Y | 191 | phosphorylation | HPRDPhosphoSiteKEA | HPRD:11368773KEA:15659558KEA:11368773 |
| LAT | ZAP70 | P43403 | Y | 226 | phosphorylation | HPRDPhosphoSiteKEA | HPRD:11368773KEA:11368773 |
| LAT | ZAP70 | P43403 | Y | 126 | phosphorylation | HPRDKEA | HPRD:11368773KEA:11368773 |
| LAT | ZAP70 | P43403 | Y | 131 | phosphorylation | HPRDKEA | HPRD:11368773KEA:11368773 |
| LAT | ZAP70 | P43403 | Y | 170 | phosphorylation | HPRDKEA | HPRD:11368773KEA:11368773 |
| LAT | ZAP70 | P43403 | Y | 190 | phosphorylation | HPRDKEA | HPRD:11368773KEA:15659558KEA:11368773 |
| LAT | ZAP70 | P43403 | Y | 225 | phosphorylation | HPRDKEA | HPRD:11368773KEA:11368773 |
| LAT | ZAP70 | P43403 | Y | 163 | phosphorylation | MIMPHPRDHPRD_MIMPPhosphoSite_MIMP | HPRD:11368773 |
| LAT | ZAP70 | P43403 | Y | 168 | phosphorylation | MIMPHPRDHPRD_MIMPPhosphoSite_MIMP | HPRD:11368773 |
Ligand-Receptor Signaling (15)
15 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | CellTalkDB | Yes | Yes | |||
| receptor | receptor | OmniPath | Yes | Yes | |||
| intracellular | intracellular | LOCATE | Yes | ||||
| intracellular | intracellular | ComPPI | Yes | ||||
| intracellular | intracellular | GO_Intercell | Yes | ||||
| intracellular | intracellular | OmniPath | Yes | ||||
| transmembrane | transmembrane | UniProt_location | Yes | ||||
| transmembrane | transmembrane | UniProt_topology | Yes | ||||
| transmembrane | transmembrane | UniProt_keyword | Yes | ||||
| transmembrane | transmembrane | TopDB | Yes |
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Regulatory Interaction Network (23)
23 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| LAT | O43561 | P85B | O00459 | Yes | Yes | NetPathWangSIGNOR | NetPath:9489702SIGNOR:11368773 | |
| LCK | P06239 | LAT | O43561 | Yes | Yes | WangiPTMnetPhosphoPointSIGNORProtMapperHPRDRLIMS-P_ProtMapperReactome_ProtMapperSIGNOR_ProtMapperREACH_ProtMapper | ProtMapper:16938345HPRD:12186560HPRD:12359715ProtMapper:27700984SIGNOR:16938345 | |
| FAK2 | Q14289 | LAT | O43561 | Yes | PhosphoSiteSparser_ProtMapperProtMapper | PhosphoSite:31189114ProtMapper:28699640PhosphoSite:28699640 |
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Protein Complex Composition (67)
67 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| DLATDLDDLSTKGD4OGDHOGDHL | P09622P10515P36957P82909Q02218Q9ULD0 | 0:0:0:0:0:0 | hu.MAP2 | |||
| DLAT | P10515 | 60 | PDB | PDB:8piu | ||
| CDC73CTR9DLATLEO1PAF1PDHBTCEA1 | P10515P11177P23193Q6P1J9Q6PD62Q8N7H5Q8WVC0 | 1:1:1:1:1:1:1 | NetworkBlastCompleat | Compleat:HC4639 | ||
| ATP5PFCDC73CTR9CTRLDLATLEO1PAF1PNPOTCEA1 | P10515P18859P23193P40313Q6P1J9Q6PD62Q8N7H5Q8WVC0Q9NVS9 | 1:1:1:1:1:1:1:1:1 | NetworkBlastCompleat | Compleat:HC3689 | ||
| DLATPDK3 | P10515Q15120 | 2:4 | PDB | PDB:2pnrPDB:1y8pPDB:1y8nPDB:1y8oPDB:2q8i | ||
| ACAD9DLATMMGT1MRPL1OCIAD2 | P10515Q56VL3Q8N4V1Q9BYD6Q9H845 | 0:0:0:0:0 | Havugimana2012 | Havugimana2012:C_490 | ||
| LAT2STAP1 | Q9GZY6Q9ULZ2 | 1:1 | PDB | PDB:3maz |
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Sequence, Structure & Domains
Sequences
Length
262
Mass
27,930
Sequence
MEEAILVPCVLGLLLLPILAMLMALCVHCHRLPGSYDSTSSDSLYPRGIQFKRPHTVAPWPPAYPPVTSYPPLSQPDLLPIPRSPQPLGGSHRTPSSRRDSDGANSVASYENEGASGIRGAQAGWGVWGPSWTRLTPVSLPPEPACEDADEDEDDYHNPGYLVVLPDSTPATSTAAPSAPALSTPGIRDSAFSMESIDDYVNVPESGESAEASLDGSREYVNVSQELHPGAAKTEPAALSSQEAEEVEEEGAPDYENLQELN
Alternative Products
Event=Alternative splicing; Named isoforms=5; Name=1; Synonyms=Long; IsoId=O43561-1; Sequence=Displayed; Name=2; Synonyms=Short; IsoId=O43561-2; Sequence=VSP_004303; Name=3; IsoId=O43561-3; Sequence=VSP_054758, VSP_004303; Name=4; IsoId=O43561-4; Sequence=VSP_054759, VSP_004303; Name=5; IsoId=O43561-5; Sequence=VSP_054759
Alternative Sequence
1; M -> MEATAASWQVAVPVLGGASRPLGPRGAASLLRAPLQM (in isoform 3); 83; Missing (in isoform 4 and isoform 5); 114..142; Missing (in isoform 2, isoform 3 and isoform 4)
Domain & Motif Annotations
Compositional Bias
243..253; Acidic residues
Region
69..115; Disordered; 161..164; Interaction with PLCG1; 200..203; Interaction with GRB2, GRAP2 and PIK3R1; 206..262; Disordered; 220..223; Interaction with GRB2, GRAP2 and PIK3R1
Clinical Relevance
Drug Targets
Literature-reported target
Drugs
Interaction Protein (5)
ENSG00000124181ENSG00000146648ENSG00000177885ENSG00000182866ENSG00000196396
Interaction Count
5
Interaction Dataset
intact_biogrid
Supporting Publications6
| PMID | Title | Related sentences |
|---|---|---|
| 27821849 | Detailed Analysis of Protein Topology of Extracellular Vesicles-Evidence of Unconventional Membrane Protein Orientation. | No related sentences available |
| 32230970 | Radiation Exposure of Peripheral Mononuclear Blood Cells Alters the Composition and Function of Secreted Extracellular Vesicles. | No related sentences available |
| 36736734 | Extracellular vesicle proteomics and phosphoproteomics identify pathways for increased risk in patients hospitalized with COVID-19 and type 2 diabetes mellitus. | No related sentences available |
| 37322475 | Comprehensive profiling of extracellular vesicles in uveitis and scleritis enables biomarker discovery and mechanism exploration. | No related sentences available |
| 38014595 | Proteome and immune responses of extracellular vesicles derived from macrophages infected with the periodontal pathogen Tannerella forsythia. | No related sentences available |
| 40465195 | Extracellular vesicle proteomics uncovers energy metabolism, complement system, and endoplasmic reticulum stress response dysregulation postexercise in males with myalgic encephalomyelitis/chronic fatigue syndrome. | No related sentences available |