Protein detail
RGS14
Regulator of G-protein signaling 14 (RGS14)
Protein symbol RGS14 | UniProt ID | EVMP score 0.50 |
Frequency 4 | Transmembrane count | Protein classification Predicted intracellular proteins |
Basic Information
Protein Names
Regulator of G-protein signaling 14 (RGS14)
Protein Class
Predicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Description
Regulator of G protein signaling 14
Chromosome
5
Position
177357924-177372596
Frequency
4
EVMP Score
0.50
Fluorescence & Localization
Tissue SpecificesophagusCell SpecificRespiratory deuterosomal cellsSingle-Nuclei Brain Specificependymal cell
Function & Pathway
Protein Function
Predicted intracellular proteins
Cellular Component
Molecular Function
- GO:0001965 G-protein alpha-subunit binding
- GO:0003924 GTPase activity
- GO:0005092 GDP-dissociation inhibitor activity
- GO:0005096 GTPase activator activity
- GO:0005515 protein binding
- GO:0008017 microtubule binding
- GO:0019901 protein kinase binding
- GO:0030159 signaling receptor complex adaptor activity
- GO:0032794 GTPase activating protein binding
Biological Process
Mediation Categories
Receptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
12 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| RGS14 | PRKACB | P22694 | T | 495 | phosphorylation | KEA | KEA:17570479 |
| RGS14 | PRKDC | P78527 | S | 260 | phosphorylation | KEA | KEA:17570479 |
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Ligand-Receptor Signaling
9 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | No | Yes | No | No | No |
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
| receptor | receptor | scConnect | No | Yes | No | No | No |
Regulatory Interaction Network
1 record.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| KAPCA | P17612 | RGS14 | O43566 | Yes | Yes | No | WangPhosphoNetworksphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDPhosphoSite_KEAKEAHPRD_KEASIGNOR_ProtMapper | HPRD:12534294ProtMapper:12534294KEA:12534294SIGNOR:12534294 |
Protein Complex Composition
5 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| GNAI1GNAT3RGS12RGS14 | A8MTJ3O14924O43566P63096 | 0:0:0:0 | hu.MAPhu.MAP2 | |||
| GNAI1GNAT3RGS14 | A8MTJ3O43566P63096 | 0:0:0 | hu.MAP | |||
| GNAI1RGS12RGS14 | O14924O43566P63096 | 0:0:0 | hu.MAP | |||
| PRKACARAP1ARGS14 | O43566P17612P62834 | 1:1:1 | CompleatCFinder | Compleat:HC9841 | ||
| GNAI1RGS14 | O43566P63096 | 2:2 | PDB | PDB:3qi2PDB:2om2PDB:2xnsPDB:3onw |
Sequence, Structure & Domains
Sequences
Length
566
Mass
61,447
Sequence
MPGKPKHLGVPNGRMVLAVSDGELSSTTGPQGQGEGRGSSLSIHSLPSGPSSPFPTEEQPVASWALSFERLLQDPLGLAYFTEFLKKEFSAENVTFWKACERFQQIPASDTQQLAQEARNIYQEFLSSQALSPVNIDRQAWLGEEVLAEPRPDMFRAQQLQIFNLMKFDSYARFVKSPLYRECLLAEAEGRPLREPGSSRLGSPDATRKKPKLKPGKSLPLGVEELGQLPPVEGPGGRPLRKSFRRELGGTANAALRRESQGSLNSSASLDLGFLAFVSSKSESHRKSLGSTEGESESRPGKYCCVYLPDGTASLALARPGLTIRDMLAGICEKRGLSLPDIKVYLVGNEQALVLDQDCTVLADQEVRLENRITFELELTALERVVRISAKPTKRLQEALQPILEKHGLSPLEVVLHRPGEKQPLDLGKLVSSVAAQRLVLDTLPGVKISKARDKSPCRSQGCPPRTQDKATHPPPASPSSLVKVPSSATGKRQTCDIEGLVELLNRVQSSGAHDQRGLLRKEDLVLPEFLQLPAQGPSSEETPPQTKSAAQPIGGSLNSTTDSAL
Alternative Products
Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=O43566-7; Sequence=Displayed; Name=2; IsoId=O43566-4; Sequence=VSP_027577, VSP_027578, VSP_027579; Name=3; IsoId=O43566-5; Sequence=VSP_027577, VSP_037959; Name=4; IsoId=O43566-6; Sequence=VSP_029426, VSP_037959
Alternative Sequence
1..153; Missing (in isoform 2 and isoform 3); 54..273; Missing (in isoform 4); 351; Q -> QK (in isoform 3 and isoform 4); 352..354; ALV -> VGT (in isoform 2); 355..566; Missing (in isoform 2)
3D Structural Models
Turn
152..155; 522..525
Helix
61..65; 68..73; 75..84; 92..105; 111..125; 144..148; 156..167; 170..174; 180..184; 499..509; 529..531
Beta Strand
87..89; 517..519
3D Structure
NMR spectroscopy (1); X-ray crystallography (4)
Domain & Motif Annotations
Compositional Bias
39..51; Polar residues; 537..550; Polar residues; 557..566; Polar residues
Domain (CC)
The RGS domain is necessary for GTPase-activating protein (GAP) activity for G subunits and localization to the nucleus and centrosomes.; DOMAIN: The GoLoco domain is necessary for GDP-dissociation inhibitor (GDI) activity, translocation out of the nucleus and interaction with G(i) alpha subunits GNAI1, GNAI2 and GNAI3..; DOMAIN: The RBD domains are necessary for localization to the nucleus and centrosomes.
Domain (FT)
67..184; RGS; 302..373; RBD 1; 375..445; RBD 2; 498..521; GoLoco
Region
19..58; Disordered; 192..243; Disordered; 299..425; Necessary for interaction with RABGEF1; 451..490; Disordered; 530..566; Disordered