Protein detail

OX2R

Orexin receptor type 2 (Ox-2-R) (Ox2-R) (Ox2R) (Hypocretin receptor type 2)

Entry name OX2R	UniProt ID O43614	EVMP confidence score 0.50
Supporting publications (n) 1	Transmembrane count 7	Protein classification FDA approved drug targetsG-protein coupled receptorsPredicted membrane proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Orexin receptor type 2 (Ox-2-R) (Ox2-R) (Ox2R) (Hypocretin receptor type 2)

Protein Class (3)

FDA approved drug targetsG-protein coupled receptorsPredicted membrane proteins

Protein Function (2)

FDA approved drug targets:Small molecule drugs
G-protein coupled receptors:GPCRs excl olfactory receptors

Transmembrane

55..75; Helical; Name=1; 89..110; Helical; Name=2; 128..150; Helical; Name=3; 171..191; Helical; Name=4; 223..243; Helical; Name=5; 305..326; Helical; Name=6; 343..366; Helical; Name=7

Transmembrane Count

Ensembl

ENSG00000137252

Entrez Gene Symbol

HCRTR2

Gene Synonym (3)

ORXR2OX2ROXR2

Gene Description

Hypocretin receptor 2

Chromosome

Position

55106460-55282617

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization2

Tissue Specificskin 1Cell SpecificBreast secretory cells

Function & Pathway8

Protein Function (2)

FDA approved drug targets:Small molecule drugs
G-protein coupled receptors:GPCRs excl olfactory receptors

Cellular Component (2)

Molecular Function (4)

Biological Process (3)

KEGG (2)

Reactome (6)

Canonical Pathways

M19 Pid p73pathway

Mediation Categories (3)

Clinical-translation mediationMetabolism mediationReceptor-signaling mediation

Relations & Evidence64

Ligand-Receptor Signaling (54)

54 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	CellPhoneDB	No	Yes	No	Yes	No
receptor	receptor	HPMR	No	Yes	No	Yes	No
receptor	receptor	CellChatDB	No	Yes	No	Yes	No
receptor	receptor	CellTalkDB	No	Yes	No	Yes	No
receptor	receptor	Surfaceome	No	Yes	No	Yes	No
receptor	receptor	Ramilowski2015	No	Yes	No	Yes	No
receptor	receptor	Guide2Pharma	No	Yes	No	Yes	No
gpcr	receptor	DGIdb	No	Yes	No	Yes	No
receptor	receptor	LRdb	No	Yes	No	Yes	No
receptor	receptor	Baccin2019	No	Yes	No	Yes	No

Page 1 of 6Next

Regulatory Interaction Network (8)

8 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
OREX	O43612	OX2R	O43614	Yes	Yes	No	iTALKGuide2Pharma_LRdbSIGNORHINTHPMR_talklrHPMRCellChatDBHPRD_LRdbtalklrscConnectHPRDRamilowski2015_Baccin2019Guide2Pharma_CellinkerWangRamilowski2015HPMR_LRdbCellPhoneDBGuide2Pharma_talklrHPRD_talklrBaccin2019CellinkerEMBRACEGuide2PharmaCellTalkDBFantom5_LRdbHPMR_CellinkerconnectomeDB2020LRdb	connectomeDB2020:12702704 scConnect:12890892 HINT:33547286 LRdb:9491897 connectomeDB2020:11162621 Guide2Pharma:12606634 scConnect:9491897 HINT:9491897 connectomeDB2020:12208495 Cellinker:9491897 LRdb:18599270 Guide2Pharma:9491897 connectomeDB2020:18599270 LRdb:11162621 Cellinker:12702704 Baccin2019:12702704 CellTalkDB:9491897 Baccin2019:18599270 scConnect:27237973 Guide2Pharma:11162621 Guide2Pharma:12702704 Baccin2019:12208495 Guide2Pharma:26582739 Guide2Pharma:27237973 LRdb:12208495 SIGNOR:9491897 connectomeDB2020:9491897 Cellinker:11162621 Guide2Pharma:18599270 scConnect:10498827 Guide2Pharma:12208495 LRdb:12702704 HPRD:9491897 scConnect:11162621 scConnect:12702704 scConnect:18599270 scConnect:12606634 scConnect:12208495 Guide2Pharma:10498827 Cellinker:18599270 Baccin2019:9491897 Cellinker:12208495 HPMR:9491897 scConnect:26582739 Baccin2019:11162621
OX2R	O43614	GNAI1	P63096	Yes	Yes	No	HINTSIGNOR	HINT:35614071 SIGNOR:31160049
OX2R	O43614	GNA13	Q14344	Yes	Yes	No	SIGNOR	SIGNOR:31160049
OX2R	O43614	GNA14	O95837	Yes	Yes	No	SIGNOR	SIGNOR:31160049
OX2R	O43614	GNAO	P09471	Yes	Yes	No	SIGNOR	SIGNOR:31160049
OX2R	O43614	GNAQ	P50148	Yes	Yes	No	SIGNOR	SIGNOR:31160049
OX2R	O43614	GNAZ	P19086	Yes	Yes	No	SIGNOR	SIGNOR:31160049
OX2R	O43614	GNAI3	P08754	Yes	Yes	No	SIGNOR	SIGNOR:31160049

Protein Complex Composition (1)

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	HCRTR2	O43614	2	PDB	PDB:6tpj

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Western blottingMass spectrometry [LTQ-FT Ultra]Mass spectrometry	20	17671216 18490724 37029374 37072829 37253066 37303669 37321426 37357686 37369038 37542121 37968711 37981065 38117249 38649419 38664722 38699039 38811625 38963761 39044233 39174921

Sequence, Structure & Domains12

Sequences

Length

444

Mass

50,694

Sequence

MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW

3D Structural Models

Turn

252..254; 332..335

Helix

40..47; 54..81; 83..85; 88..106; 108..117; 123..156; 166..183; 185..190; 218..231; 233..251; 294..328; 339..367; 369..381

Beta Strand

158..160; 191..196; 199..202; 207..212; 215..217

3D Structure

Electron microscopy (4); X-ray crystallography (7)

Domain & Motif Annotations

Compositional Bias

1..10; Basic and acidic residues

Domain (CC)

The N-terminal region is required for orexin signaling.

Region

1..20; Disordered; 33..49; Required for response to orexin-A

Protein Families

G-protein coupled receptor 1 family

Sequence Similarities

Belongs to the G-protein coupled receptor 1 family.

Clinical Relevance6

Disease Involvement

FDA approved drug targets

Related Diseases (3)

Depression Insomnia Narcolepsy

Biomarker

Phase 2; Approved; Phase 1

Drug Targets

FDA approved drug targets

Drugs (11)

LEMBOREXANT NULL MK-3697 ORN-0829 HYDRATE SUVOREXANT SELTOREXANT ALMOREXANT SB-649868 DARIDOREXANT HYDROCHLORIDE FILOREXANT DARIDOREXANT

Antibody (2)

HPA054516 HPA070481

Supporting Publications1

PMID	Title	Abstract
37427430	Multiomics of Tissue Extracellular Vesicles Identifies Unique Modulators of Atherosclerosis and Calcific Aortic Valve Stenosis.	No abstract available