Protein detail
PLPP2
Phospholipid phosphatase 2 (EC 3.1.3.-) (EC 3.1.3.4) (Lipid phosphate phosphohydrolase 2) (PAP2-gamma) (PAP2-G) (Phosphatidate phosphohydrolase type 2c) (Phosphatidic acid phosphatase 2c) (PAP-2c) (PAP2c)
Protein symbol PLPP2 | UniProt ID | EVMP score 0.50 |
Frequency 2 | Transmembrane count 6 | Protein classification EnzymesMetabolic proteinsPredicted membrane proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Phospholipid phosphatase 2 (EC 3.1.3.-) (EC 3.1.3.4) (Lipid phosphate phosphohydrolase 2) (PAP2-gamma) (PAP2-G) (Phosphatidate phosphohydrolase type 2c) (Phosphatidic acid phosphatase 2c) (PAP-2c) (PAP2c)
Protein Class
EnzymesMetabolic proteinsPredicted membrane proteins
Protein Function
- Enzymes
- ENZYME proteins:Hydrolases
Transmembrane
5..25; Helical; 52..72; Helical; 88..108; Helical; 163..183; Helical; 197..217; Helical; 227..247; Helical
Transmembrane Count
6
Ensembl
Entrez Gene Symbol
Gene Synonym
LPP2PAP-2cPPAP2C
Gene Description
Phospholipid phosphatase 2
Chromosome
19
Position
281040-291403
Frequency
2
EVMP Score
0.50
Fluorescence & Localization
Tissue SpecificbrainCell SpecificAstrocytesSingle-Nuclei Brain Specificcommitted oligodendrocyte precursorBlood Cell SpecificneutrophilBlood Lineage Specificdendritic cells
Function & Pathway
Protein Function
- Enzymes
- ENZYME proteins:Hydrolases
Cellular Component
Molecular Function
Biological Process
KEGG
- hsa00561 Glycerolipid metabolism
- KEGG:hsa00564 Glycerophospholipid metabolism
- KEGG:hsa00565 Ether lipid metabolism
- KEGG:hsa00600 Sphingolipid metabolism
- KEGG:hsa01100 Metabolic pathways
- KEGG:hsa04072 Phospholipase D signaling pathway
- KEGG:hsa04666 Fc gamma R-mediated phagosome formation
- KEGG:hsa04975 Fat digestion and absorption
- KEGG:hsa05231 Choline metabolism in cancer
Reactome
Mediation Categories
Fusion and delivery mediationMetabolism mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
21 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane | transmembrane_predicted | Phobius | No | No | No | No | No |
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Regulatory Interaction Network
0 records.
Protein Complex Composition
0 records.
Sequence, Structure & Domains
Sequences
Length
288
Mass
32,574
Sequence
MQRRWVFVLLDVLCLLVASLPFAILTLVNAPYKRGFYCGDDSIRYPYRPDTITHGLMAGVTITATVILVSAGEAYLVYTDRLYSRSDFNNYVAAVYKVLGTFLFGAAVSQSLTDLAKYMIGRLRPNFLAVCDPDWSRVNCSVYVQLEKVCRGNPADVTEARLSFYSGHSSFGMYCMVFLALYVQARLCWKWARLLRPTVQFFLVAFALYVGYTRVSDYKHHWSDVLVGLLQGALVAALTVCYISDFFKARPPQHCLKEEELERKPSLSLTLTLGEADHNHYGYPHSSS
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=O43688-1; Sequence=Displayed; Name=2; IsoId=O43688-2; Sequence=VSP_037765; Name=3; IsoId=O43688-3; Sequence=VSP_047366
Alternative Sequence
1..56; Missing (in isoform 3); 1..17; MQRRWVFVLLDVLCLLV -> MGVARGPGSRGQHPPPRQQEVCAEGPRARLHPAPPGLG (in isoform 2)
3D Structural Models
Domain & Motif Annotations
Region
117..125; Phosphatase sequence motif I; 165..168; Phosphatase sequence motif II; 213..224; Phosphatase sequence motif III
Protein Families
PA-phosphatase related phosphoesterase family
Sequence Similarities
Belongs to the PA-phosphatase related phosphoesterase family.