Protein detail

MYO1B

Unconventional myosin-Ib (MYH-1c) (Myosin I alpha) (MMI-alpha) (MMIa)

Entry name MYO1B	UniProt ID O43795	EVMP confidence score 0.38
Supporting publications (n) 1	Transmembrane count	Protein classification Predicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Unconventional myosin-Ib (MYH-1c) (Myosin I alpha) (MMI-alpha) (MMIa)

Protein Class

Predicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000128641

Entrez Gene Symbol

MYO1B

Gene Synonym

myr1

Gene Description

Myosin IB

Chromosome

Position

191245185-191425389

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization6

Cell SpecificFibroblastsSingle-Nuclei Brain SpecificfibroblastBlood Cell SpecificeosinophilSecretome LocationSecreted to extracellular matrixSecretome FunctionCell adhesion

Function & Pathway7

Protein Function

Predicted intracellular proteins

Cellular Component (15)

Page 1 of 2

Molecular Function (8)

Biological Process (3)

KEGG (3)

Canonical Pathways (3)

M290 Pid il12 stat4 pathway
M196 Pid il23 pathway
M88 Pid cd8 tcr pathway

Mediation Categories

Fusion and delivery mediation

Relations & Evidence7

Ligand-Receptor Signaling (4)

4 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Regulatory Interaction Network (1)

1 record.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
EPHB2	P29323	MYO1B	O43795	Yes	Yes	No	SIGNOR	SIGNOR:26195670

Protein Complex Composition (1)

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	DLG5 MYO1B TPM1	O43795 P09493 Q8TDM6	0:0:0	hu.MAP

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Western blottingFlow cytometry	2	27894104 38321535

Sequence, Structure & Domains9

Sequences

Length

1,136

Mass

131,985

Sequence

MAKMEVKTSLLDNMIGVGDMVLLEPLNEETFINNLKKRFDHSEIYTYIGSVVISVNPYRSLPIYSPEKVEEYRNRNFYELSPHIFALSDEAYRSLRDQDKDQCILITGESGAGKTEASKLVMSYVAAVCGKGAEVNQVKEQLLQSNPVLEAFGNAKTVRNDNSSRFGKYMDIEFDFKGDPLGGVISNYLLEKSRVVKQPRGERNFHVFYQLLSGASEELLNKLKLERDFSRYNYLSLDSAKVNGVDDAANFRTVRNAMQIVGFMDHEAESVLAVVAAVLKLGNIEFKPESRVNGLDESKIKDKNELKEICELTGIDQSVLERAFSFRTVEAKQEKVSTTLNVAQAYYARDALAKNLYSRLFSWLVNRINESIKAQTKVRKKVMGVLDIYGFEIFEDNSFEQFIINYCNEKLQQIFIELTLKEEQEEYIREDIEWTHIDYFNNAIICDLIENNTNGILAMLDEECLRPGTVTDETFLEKLNQVCATHQHFESRMSKCSRFLNDTSLPHSCFRIQHYAGKVLYQVEGFVDKNNDLLYRDLSQAMWKASHALIKSLFPEGNPAKINLKRPPTAGSQFKASVATLMKNLQTKNPNYIRCIKPNDKKAAHIFNEALVCHQIRYLGLLENVRVRRAGYAFRQAYEPCLERYKMLCKQTWPHWKGPARSGVEVLFNELEIPVEEYSFGRSKIFIRNPRTLFKLEDLRKQRLEDLATLIQKIYRGWKCRTHFLLMKKSQIVIAAWYRRYAQQKRYQQTKSSALVIQSYIRGWKARKILRELKHQKRCKEAVTTIAAYWHGTQARRELRRLKEEARNKHAIAVIWAYWLGSKARRELKRLKEEARRKHAVAVIWAYWLGLKVRREYRKFFRANAGKKIYEFTLQRIVQKYFLEMKNKMPSLSPIDKNWPSRPYLFLDSTHKELKRIFHLWRCKKYRDQFTDQQKLIYEEKLEASELFKDKKALYPSSVGQPFQGAYLEINKNPKYKKLKDAIEEKIIIAEVVNKINRANGKSTSRIFLLTNNNLLLADQKSGQIKSEVPLVDVTKVSMSSQNDGFFAVHLKEGSEAASKGDFLFSSDHLIEMATKLYRTTLSQTKQKLNIEISDEFLVQFRQDKVCVKFIQGNQKNGSVPTCKRKNNRLLEVAVP

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O43795-1; Sequence=Displayed; Name=2; IsoId=O43795-2; Sequence=VSP_012759

Alternative Sequence

795..852; Missing (in isoform 2)

Domain & Motif Annotations

Domain (FT)

15..701; Myosin motor; 704..733; IQ 1; 728..748; IQ 2; 750..779; IQ 3; 779..808; IQ 4; 808..837; IQ 5; 837..866; IQ 6; 952..1136; TH1

Region

578..600; Actin-binding

Protein Families (2)

TRAFAC class myosin-kinesin ATPase superfamily
Myosin family

Sequence Similarities

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

Clinical Relevance4

Antibody (2)

HPA013607 HPA060144

Interaction Protein (3)

ENSG00000160014ENSG00000197879ENSG00000198668

Interaction Count

Interaction Dataset

biogrid_opencell

Supporting Publications1

PMID	Title	Abstract
38852279	Exosomal mRNA Cargo are biomarkers of tumor and immune cell populations in pediatric osteosarcoma.	Exosome isolation was verified by CD9 immunoblot and characterized on electron microscopy. Peripheral blood exosomes of osteosarcoma patients at diagnosis were significantly smaller than those of controls and overexpressed extracellular matrix protein gene THBS1 and B cell markers MS4A1 and TCL1A.