Protein detail
EDIL3
EGF-like repeat and discoidin I-like domain-containing protein 3 (Developmentally-regulated endothelial cell locus 1 protein) (Integrin-binding protein DEL1)
Entry name EDIL3 | UniProt ID | EVMP confidence score 0.38 |
Supporting publications (n) 1 | Transmembrane count | Protein classification Predicted secreted proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information11
Protein Names
EGF-like repeat and discoidin I-like domain-containing protein 3 (Developmentally-regulated endothelial cell locus 1 protein) (Integrin-binding protein DEL1)
Protein Class
Predicted secreted proteins
Protein Function
Predicted secreted proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
DEL1
Gene Description
EGF like repeats and discoidin domains 3
Chromosome
5
Position
83940554-84384880
Supporting publications (n)
1
EVMP confidence score
0.38
Fluorescence & Localization1
Function & Pathway5
Protein Function
Predicted secreted proteins
Cellular Component (3)
Molecular Function (3)
Reactome (3)
Mediation Categories
Adhesion and uptake mediation
Relations & Evidence31
Ligand-Receptor Signaling (29)
29 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| ecm | ecm | GO_Intercell | Yes | No | Yes | No | No |
| ecm | ecm | OmniPath | Yes | No | Yes | No | No |
| extracellular | extracellular | LOCATE | No | No | Yes | No | No |
| extracellular | extracellular | OmniPath | No | No | Yes | No | No |
| adhesion | adhesion | MCAM | Yes | Yes | Yes | No | No |
| cell_adhesion | cell_adhesion | Zhong2015 | Yes | Yes | Yes | No | No |
| icam | cell_adhesion | Zhong2015 | Yes | Yes | Yes | No | No |
| adhesion | adhesion | OmniPath | Yes | Yes | Yes | No | No |
| cell_adhesion | cell_adhesion | OmniPath | Yes | Yes | Yes | No | No |
| secreted | secreted | UniProt_keyword | No | No | Yes | No | No |
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Protein Complex Composition (1)
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Western blotting | 1 | 37922300 |
Sequence, Structure & Domains12
Sequences
Length
480
Mass
53,765
Sequence
MKRSVAVWLLVGLSLGVPQFGKGDICDPNPCENGGICLPGLADGSFSCECPDGFTDPNCSSVVEVASDEEEPTSAGPCTPNPCHNGGTCEISEAYRGDTFIGYVCKCPRGFNGIHCQHNINECEVEPCKNGGICTDLVANYSCECPGEFMGRNCQYKCSGPLGIEGGIISNQQITASSTHRALFGLQKWYPYYARLNKKGLINAWTAAENDRWPWIQINLQRKMRVTGVITQGAKRIGSPEYIKSYKIAYSNDGKTWAMYKVKGTNEDMVFRGNIDNNTPYANSFTPPIKAQYVRLYPQVCRRHCTLRMELLGCELSGCSEPLGMKSGHIQDYQITASSIFRTLNMDMFTWEPRKARLDKQGKVNAWTSGHNDQSQWLQVDLLVPTKVTGIITQGAKDFGHVQFVGSYKLAYSNDGEHWTVYQDEKQRKDKVFQGNFDNDTHRKNVIDPPIYARHIRILPWSWYGRITLRSELLGCTEEE
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=Long; IsoId=O43854-1; Sequence=Displayed; Name=2; Synonyms=Short, Z20; IsoId=O43854-2; Sequence=VSP_050006, VSP_050007
Alternative Sequence
66; A -> G (in isoform 2); 67..76; Missing (in isoform 2)
3D Structural Models
Turn
56..59; 66..70; 122..125
Helix
32..34
Beta Strand
36..38; 47..49; 88..91; 103..106; 111..113; 133..137; 140..144
3D Structure
X-ray crystallography (1)
Domain & Motif Annotations
Motif
96..98; Cell attachment site
Domain (CC)
EGF2 and EGF3 form a rigid rod via an interdomain calcium ion binding site, while the long linker between EGF1 and EGF2 lends considerable flexibility to EGF1.
Domain (FT)
24..60; EGF-like 1; 74..117; EGF-like 2; 119..155; EGF-like 3; 158..314; F5/8 type C 1; 319..476; F5/8 type C 2
Supporting Publications1
| PMID | Title | Abstract |
|---|---|---|
| 40784529 | Serum-derived exosome proteomics unveils the distinct and adjustable nature of the dampness constitution in traditional Chinese medicine. | No abstract available |