Protein detail

XPP2

Xaa-Pro aminopeptidase 2 (EC 3.4.11.9) (Aminoacylproline aminopeptidase) (Membrane-bound aminopeptidase P) (Membrane-bound APP) (Membrane-bound AmP) (mAmP) (X-Pro aminopeptidase 2)

Entry name XPP2	UniProt ID O43895	EVMP confidence score 0.28
Supporting publications (n) 1	Transmembrane count	Protein classification Disease related genesEnzymesPotential drug targetsPredicted intracellular proteins

Basic Information

Protein Names

Xaa-Pro aminopeptidase 2 (EC 3.4.11.9) (Aminoacylproline aminopeptidase) (Membrane-bound aminopeptidase P) (Membrane-bound APP) (Membrane-bound AmP) (mAmP) (X-Pro aminopeptidase 2)

Protein Class (4)

Disease related genesEnzymesPotential drug targetsPredicted intracellular proteins

Protein Function (6)

Predicted intracellular proteins
Potential drug targets
Enzymes
ENZYME proteins:Hydrolases
Peptidases:Metallopeptidases
Disease related genes

Ensembl

ENSG00000122121

Entrez Gene Symbol

XPNPEP2

Gene Description

X-prolyl aminopeptidase 2

Chromosome

Position

129738949-129769536

Supporting publications (n)

EVMP confidence score

0.28

Fluorescence & Localization

Tissue SpecificintestineCell SpecificPlasma cellsSingle-Nuclei Brain SpecificleukocyteBlood Cell SpecificT-regBlood Lineage SpecificB-cells

Function & Pathway

Protein Function (6)

Predicted intracellular proteins
Potential drug targets
Enzymes
ENZYME proteins:Hydrolases
Peptidases:Metallopeptidases
Disease related genes

Cellular Component (5)

Molecular Function (3)

Biological Process (3)

KEGG

hsa04974 Protein digestion and absorption

Reactome (2)

Mediation Categories

Metabolism mediation

Relations & Evidence12

Ligand-Receptor Signaling (10)

10 records.

Category	Parent	Database	Transmitter	Receiver
receptor	receptor	OmniPath		Yes
ecm	ecm	MatrixDB	Yes
ecm	ecm	OmniPath	Yes
transmembrane	transmembrane	Ramilowski_location
transmembrane	transmembrane	OmniPath
plasma_membrane	plasma_membrane	UniProt_location
plasma_membrane	plasma_membrane	OmniPath
cell_surface	cell_surface	Surfaceome
cell_surface	cell_surface	OmniPath
receptor	receptor	scConnect		Yes

Protein Complex Composition (1)

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
HT_DM_Cluster30	NAGK NKAP NKAPL PITRM1 SNRNP70 SNRPA1 SNRPC SNRPF SRRM2 SUB1 XPNPEP1 XPNPEP2	O43895 P08621 P09234 P09661 P53999 P62306 Q5JRX3 Q5M9Q1 Q8N5F7 Q9NQW7 Q9UJ70 Q9UQ35	1:1:1:1:1:1:1:1:1:1:1:1	Compleat	Compleat:HC2557	22036573

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	1	30915084

Sequence, Structure & Domains

Sequences

Length

674

Mass

75,625

Sequence

MARAHWGCCPWLVLLCACAWGHTKPVDLGGQDVRNCSTNPPYLPVTVVNTTMSLTALRQQMQTQNLSAYIIPGTDAHMNEYIGQHDERRAWITGFTGSAGTAVVTMKKAAVWTDSRYWTQAERQMDCNWELHKEVGTTPIVTWLLTEIPAGGRVGFDPFLLSIDTWESYDLALQGSNRQLVSITTNLVDLVWGSERPPVPNQPIYALQEAFTGSTWQEKVSGVRSQMQKHQKVPTAVLLSALEETAWLFNLRASDIPYNPFFYSYTLLTDSSIRLFANKSRFSSETLSYLNSSCTGPMCVQIEDYSQVRDSIQAYSLGDVRIWIGTSYTMYGIYEMIPKEKLVTDTYSPVMMTKAVKNSKEQALLKASHVRDAVAVIRYLVWLEKNVPKGTVDEFSGAEIVDKFRGEEQFSSGPSFETISASGLNAALAHYSPTKELNRKLSSDEMYLLDSGGQYWDGTTDITRTVHWGTPSAFQKEAYTRVLIGNIDLSRLIFPAATSGRMVEAFARRALWDAGLNYGHGTGHGIGNFLCVHEWPVGFQSNNIAMAKGMFTSIEPGYYKDGEFGIRLEDVALVVEAKTKYPGSYLTFEVVSFVPYDRNLIDVSLLSPEHLQYLNRYYQTIREKVGPELQRRQLLEEFEWLQQHTEPLAARAPDTASWASVLVVSTLAILGWSV

Domain & Motif Annotations

Protein Families

Peptidase M24B family

Sequence Similarities

Belongs to the peptidase M24B family.

Clinical Relevance

Drugs

TOSEDOSTAT

Antibody (4)

HPA000339 CAB025136 CAB025269 HPA064568

Supporting Publications1

PMID	Title	Related sentences
41216884	Extracellular Vesicles From Multiple Sclerosis White Matter Exhibit Synaptic, Mitochondrial, Complement and Ageing-Related Pathway Dysregulation.	No related sentences available