Protein detail
XPP2
Xaa-Pro aminopeptidase 2 (EC 3.4.11.9) (Aminoacylproline aminopeptidase) (Membrane-bound aminopeptidase P) (Membrane-bound APP) (Membrane-bound AmP) (mAmP) (X-Pro aminopeptidase 2)
Entry name XPP2 | UniProt ID | EVMP confidence score 0.50 |
Supporting publications (n) 1 | Transmembrane count | Protein classification Disease related genesEnzymesPotential drug targetsPredicted intracellular proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information10
Protein Names
Xaa-Pro aminopeptidase 2 (EC 3.4.11.9) (Aminoacylproline aminopeptidase) (Membrane-bound aminopeptidase P) (Membrane-bound APP) (Membrane-bound AmP) (mAmP) (X-Pro aminopeptidase 2)
Protein Class (4)
Disease related genesEnzymesPotential drug targetsPredicted intracellular proteins
Protein Function (6)
- Predicted intracellular proteins
- Potential drug targets
- Enzymes
- ENZYME proteins:Hydrolases
- Peptidases:Metallopeptidases
- Disease related genes
Ensembl
Entrez Gene Symbol
Gene Description
X-prolyl aminopeptidase 2
Chromosome
X
Position
129738949-129769536
Supporting publications (n)
1
EVMP confidence score
0.50
Fluorescence & Localization5
Tissue SpecificintestineCell SpecificPlasma cellsSingle-Nuclei Brain SpecificleukocyteBlood Cell SpecificT-regBlood Lineage SpecificB-cells
Function & Pathway7
Protein Function (6)
- Predicted intracellular proteins
- Potential drug targets
- Enzymes
- ENZYME proteins:Hydrolases
- Peptidases:Metallopeptidases
- Disease related genes
Cellular Component (5)
Molecular Function (3)
Biological Process (3)
Reactome (2)
Mediation Categories
Metabolism mediation
Relations & Evidence12
Ligand-Receptor Signaling (10)
10 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | No | Yes | No | No | No |
| ecm | ecm | MatrixDB | Yes | No | No | No | No |
| ecm | ecm | OmniPath | Yes | No | No | No | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | No | No | No |
| transmembrane | transmembrane | OmniPath | No | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
| cell_surface | cell_surface | Surfaceome | No | No | No | No | No |
| cell_surface | cell_surface | OmniPath | No | No | No | No | No |
| receptor | receptor | scConnect | No | Yes | No | No | No |
Protein Complex Composition (1)
1 record.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| HT_DM_Cluster30 | NAGKNKAPNKAPLPITRM1SNRNP70SNRPA1SNRPCSNRPFSRRM2SUB1XPNPEP1XPNPEP2 | O43895P08621P09234P09661P53999P62306Q5JRX3Q5M9Q1Q8N5F7Q9NQW7Q9UJ70Q9UQ35 | 1:1:1:1:1:1:1:1:1:1:1:1 | Compleat | Compleat:HC2557 | 22036573 |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass spectrometry | 1 | 30915084 |
Sequence, Structure & Domains5
Sequences
Length
674
Mass
75,625
Sequence
MARAHWGCCPWLVLLCACAWGHTKPVDLGGQDVRNCSTNPPYLPVTVVNTTMSLTALRQQMQTQNLSAYIIPGTDAHMNEYIGQHDERRAWITGFTGSAGTAVVTMKKAAVWTDSRYWTQAERQMDCNWELHKEVGTTPIVTWLLTEIPAGGRVGFDPFLLSIDTWESYDLALQGSNRQLVSITTNLVDLVWGSERPPVPNQPIYALQEAFTGSTWQEKVSGVRSQMQKHQKVPTAVLLSALEETAWLFNLRASDIPYNPFFYSYTLLTDSSIRLFANKSRFSSETLSYLNSSCTGPMCVQIEDYSQVRDSIQAYSLGDVRIWIGTSYTMYGIYEMIPKEKLVTDTYSPVMMTKAVKNSKEQALLKASHVRDAVAVIRYLVWLEKNVPKGTVDEFSGAEIVDKFRGEEQFSSGPSFETISASGLNAALAHYSPTKELNRKLSSDEMYLLDSGGQYWDGTTDITRTVHWGTPSAFQKEAYTRVLIGNIDLSRLIFPAATSGRMVEAFARRALWDAGLNYGHGTGHGIGNFLCVHEWPVGFQSNNIAMAKGMFTSIEPGYYKDGEFGIRLEDVALVVEAKTKYPGSYLTFEVVSFVPYDRNLIDVSLLSPEHLQYLNRYYQTIREKVGPELQRRQLLEEFEWLQQHTEPLAARAPDTASWASVLVVSTLAILGWSV
Domain & Motif Annotations
Protein Families
Peptidase M24B family
Sequence Similarities
Belongs to the peptidase M24B family.
Clinical Relevance2
Drugs
Supporting Publications1
| PMID | Title | Abstract |
|---|---|---|
| 41216884 | Extracellular Vesicles From Multiple Sclerosis White Matter Exhibit Synaptic, Mitochondrial, Complement and Ageing-Related Pathway Dysregulation. | No abstract available |