Protein detail

GAS2

Growth arrest-specific protein 2 (GAS-2)

Entry name GAS2	UniProt ID O43903	EVMP confidence score 0.50
Supporting publications (n) 2	Transmembrane count	Protein classification Predicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information10

Protein Names

Growth arrest-specific protein 2 (GAS-2)

Protein Class

Predicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000148935

Entrez Gene Symbol

GAS2

Gene Description

Growth arrest specific 2

Chromosome

Position

22625509-22813001

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization5

Tissue SpecifickidneyCell SpecificDistal convoluted tubule cellsBlood Cell Specificplasmacytoid DCBlood Lineage Specificdendritic cells

Function & Pathway6

Protein Function

Predicted intracellular proteins

Cellular Component (4)

Molecular Function (3)

Biological Process (3)

Reactome (5)

Mediation Categories

Fusion and delivery mediation

Relations & Evidence9

Enzyme-Mediated Modification (2)

2 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
GAS2	CASP3	P42574	D	278	cleavage	HPRDSIGNOR	HPRD:10564664 SIGNOR:10564664
GAS2	CASP7	P55210	D	278	cleavage	HPRD	HPRD:10564664 HPRD:1056466

Ligand-Receptor Signaling (4)

4 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Regulatory Interaction Network (2)

2 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
CASP3	P42574	GAS2	O43903	Yes	Yes	No	MacrophageSIGNORCui2007WangHPRD-phos	SIGNOR:10564664 HPRD-phos:10564664 Macrophage:10564664
	COMPLEX:P42574	GAS2	O43903	Yes	Yes	No	SIGNOR	SIGNOR:10564664

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Antibody arrayMass spectrometry	1	38716512

Sequence, Structure & Domains10

Sequences

Length

313

Mass

34,945

Sequence

MCTALSPKVRSGPGLSDMHQYSQWLASRHEANLLPMKEDLALWLTNLLGKEITAETFMEKLDNGALLCQLAETMQEKFKESMDANKPTKNLPLKKIPCKTSAPSGSFFARDNTANFLSWCRDLGVDETCLFESEGLVLHKQPREVCLCLLELGRIAARYGVEPPGLIKLEKEIEQEETLSAPSPSPSPSSKSSGKKSTGNLLDDAVKRISEDPPCKCPNKFCVERLSQGRYRVGEKILFIRMLHNKHVMVRVGGGWETFAGYLLKHDPCRMLQISRVDGKTSPIQSKSPTLKDMNPDNYLVVSASYKAKKEIK

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O43903-1; Sequence=Displayed; Name=2; IsoId=O43903-2; Sequence=VSP_055080, VSP_055081

Alternative Sequence

137..141; VLHKQ -> GFGGQ (in isoform 2); 142..313; Missing (in isoform 2)

Domain & Motif Annotations

Compositional Bias

188..197; Low complexity

Domain (FT)

34..156; Calponin-homology (CH); 197..270; GAR

Region

175..199; Disordered

Protein Families

GAS2 family

Sequence Similarities

Belongs to the GAS2 family.

Clinical Relevance3

Disease Involvement (2)

DeafnessNon-syndromic deafness

Drugs (13)

SCRIPTAID BELINOSTAT TRICHOSTATIN A DACINOSTAT TMP269 ROMIDEPSIN PANOBINOSTAT QUISINOSTAT KA1010 GIVINOSTAT ENTINOSTAT VORINOSTAT CUDC-101

Antibody

HPA058904

Supporting Publications2

PMID	Title	Abstract
38731868	The Deep Proteomics Approach Identified Extracellular Vesicular Proteins Correlated to Extracellular Matrix in Type One and Two Endometrial Cancer.	No abstract available
40784529	Serum-derived exosome proteomics unveils the distinct and adjustable nature of the dampness constitution in traditional Chinese medicine.	No abstract available