Protein detail
GAS2
Growth arrest-specific protein 2 (GAS-2)
Protein symbol GAS2 | UniProt ID | EVMP score 0.50 |
Frequency 2 | Transmembrane count | Protein classification Predicted intracellular proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Growth arrest-specific protein 2 (GAS-2)
Protein Class
Predicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Description
Growth arrest specific 2
Chromosome
11
Position
22625509-22813001
Frequency
2
EVMP Score
0.50
Fluorescence & Localization
Tissue SpecifickidneyCell SpecificDistal convoluted tubule cellsBlood Cell Specificplasmacytoid DCBlood Lineage Specificdendritic cells
Function & Pathway
Protein Function
Predicted intracellular proteins
Cellular Component
Molecular Function
Biological Process
Reactome
Mediation Categories
Fusion and delivery mediation
Relations & Evidence
Enzyme-Mediated Modification
2 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| GAS2 | CASP3 | P42574 | D | 278 | cleavage | HPRDSIGNOR | HPRD:10564664SIGNOR:10564664 |
| GAS2 | CASP7 | P55210 | D | 278 | cleavage | HPRD | HPRD:10564664HPRD:1056466 |
Ligand-Receptor Signaling
4 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
2 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| CASP3 | P42574 | GAS2 | O43903 | Yes | Yes | No | MacrophageSIGNORCui2007WangHPRD-phos | SIGNOR:10564664HPRD-phos:10564664Macrophage:10564664 |
| COMPLEX:P42574 | GAS2 | O43903 | Yes | Yes | No | SIGNOR | SIGNOR:10564664 |
Protein Complex Composition
0 records.
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Antibody arrayMass spectrometry | 1 | 38716512 |
Sequence, Structure & Domains
Sequences
Length
313
Mass
34,945
Sequence
MCTALSPKVRSGPGLSDMHQYSQWLASRHEANLLPMKEDLALWLTNLLGKEITAETFMEKLDNGALLCQLAETMQEKFKESMDANKPTKNLPLKKIPCKTSAPSGSFFARDNTANFLSWCRDLGVDETCLFESEGLVLHKQPREVCLCLLELGRIAARYGVEPPGLIKLEKEIEQEETLSAPSPSPSPSSKSSGKKSTGNLLDDAVKRISEDPPCKCPNKFCVERLSQGRYRVGEKILFIRMLHNKHVMVRVGGGWETFAGYLLKHDPCRMLQISRVDGKTSPIQSKSPTLKDMNPDNYLVVSASYKAKKEIK
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O43903-1; Sequence=Displayed; Name=2; IsoId=O43903-2; Sequence=VSP_055080, VSP_055081
Alternative Sequence
137..141; VLHKQ -> GFGGQ (in isoform 2); 142..313; Missing (in isoform 2)
3D Structural Models
Domain & Motif Annotations
Compositional Bias
188..197; Low complexity
Domain (FT)
34..156; Calponin-homology (CH); 197..270; GAR
Region
175..199; Disordered
Protein Families
GAS2 family
Sequence Similarities
Belongs to the GAS2 family.
Clinical Relevance
Disease Involvement
DeafnessNon-syndromic deafness
Drugs
Antibody