Protein detail
ADCY3
Adenylate cyclase type 3 (EC 4.6.1.1) (ATP pyrophosphate-lyase 3) (Adenylate cyclase type III) (AC-III) (Adenylate cyclase, olfactive type) (Adenylyl cyclase 3) (AC3)
Entry name ADCY3 | UniProt ID | EVMP confidence score 0.53 |
Supporting publications (n) 3 | Transmembrane count 12 | Protein classification Disease related genesEnzymesHuman disease related genesMetabolic proteinsPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Adenylate cyclase type 3 (EC 4.6.1.1) (ATP pyrophosphate-lyase 3) (Adenylate cyclase type III) (AC-III) (Adenylate cyclase, olfactive type) (Adenylyl cyclase 3) (AC3)
Protein Class (7)
Disease related genesEnzymesHuman disease related genesMetabolic proteinsPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins
Protein Function (5)
- Predicted intracellular proteins
- ENZYME proteins:Lyases
- Human disease related genes:Endocrine and metabolic diseases:Other endocrine and metabolic diseases
- Enzymes
- Disease related genes
Transmembrane
80..100; Helical; 105..125; Helical; 139..159; Helical; 173..193; Helical; 226..246; Helical; 381..401; Helical; 633..653; Helical; 664..684; Helical; 708..728; Helical; 754..774; Helical; 775..795; Helical; 833..853; Helical
Transmembrane Count
12
Ensembl
Entrez Gene Symbol
Gene Synonym
AC3
Gene Description
Adenylate cyclase 3
Chromosome
2
Position
24819169-24920237
Supporting publications (n)
3
EVMP confidence score
0.53
Fluorescence & Localization
Cell SpecificLate spermatids
Function & Pathway
Protein Function (5)
- Predicted intracellular proteins
- ENZYME proteins:Lyases
- Human disease related genes:Endocrine and metabolic diseases:Other endocrine and metabolic diseases
- Enzymes
- Disease related genes
Cellular Component (6)
Molecular Function (4)
Biological Process (3)
KEGG (54)
- hsa00230 Purine metabolism
- KEGG:hsa01100 Metabolic pathways
- KEGG:hsa01522 Endocrine resistance
- KEGG:hsa04015 Rap1 signaling pathway
- KEGG:hsa04020 Calcium signaling pathway
- KEGG:hsa04022 cGMP-PKG signaling pathway
- KEGG:hsa04024 cAMP signaling pathway
- KEGG:hsa04062 Chemokine signaling pathway
- KEGG:hsa04072 Phospholipase D signaling pathway
- KEGG:hsa04081 Hormone signaling
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Reactome (36)
- R-hsa-170660 adenylate cyclase activating pathway
- R-hsa-170670 adenylate cyclase inhibitory pathway
- R-hsa-9660821 adora2b mediated anti inflammatory cytokines production
- R-hsa-9662851 anti inflammatory response favouring leishmania parasite infection
- R-hsa-445717 aquaporin mediated transport
- R-hsa-111996 ca dependent events
- R-hsa-9855142 cellular responses to mechanical stimuli
- R-hsa-8953897 cellular responses to stimuli
- R-hsa-1489509 dag and ip3 signaling
- R-hsa-9664323 fcgr3a mediated il10 synthesis
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Mediation Categories (4)
Clinical-translation mediationFusion and delivery mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence28
Enzyme-Mediated Modification (4)
4 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| ADCY3 | CAMK2G | Q13555 | S | 1,076 | phosphorylation | phosphoELM_MIMPMIMPHPRD_MIMPSIGNORProtMapperHPRDKEASIGNOR_ProtMapper | KEA:8798667SIGNOR:8798667ProtMapper:8798667KEA:9768837HPRD:8798667HPRD:9768837 |
| ADCY3 | CAMK2A | Q9UQM7 | S | 1,076 | phosphorylation | KEA | KEA:9768837KEA:8798667 |
| ADCY3 | CAMK2B | Q13554 | S | 1,076 | phosphorylation | KEA | KEA:9768837KEA:8798667 |
| ADCY3 | CAMK2D | Q13557 | S | 1,076 | phosphorylation | KEA | KEA:9768837KEA:8798667 |
Ligand-Receptor Signaling (19)
19 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane | transmembrane | OmniPath | |||||
| transmembrane | transmembrane | LOCATE | |||||
| transmembrane | transmembrane | Ramilowski_location | |||||
| plasma_membrane | plasma_membrane | UniProt_location | |||||
| plasma_membrane | plasma_membrane | OmniPath | |||||
| cell_surface | cell_surface | Surfaceome | |||||
| cell_surface | cell_surface | OmniPath | |||||
| receptor | receptor | scConnect | Yes | ||||
| transmembrane | transmembrane_predicted | Phobius |
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Regulatory Interaction Network (2)
2 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| KCC2G | Q13555 | ADCY3 | O60266 | Yes | Yes | phosphoELM_MIMPMIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDPhosphoSite_KEAKEAHPRD_KEASIGNOR_ProtMapperHPRD-phos | HPRD-phos:9768837ProtMapper:9768837KEA:8798667SIGNOR:8798667ProtMapper:8798667HPRD-phos:8798667KEA:9768837HPRD:8798667HPRD:9768837 | |
| GNAL | P38405 | ADCY3 | O60266 | Yes | Yes | WangSIGNOR | SIGNOR:23817016 |
Protein Complex Composition (2)
Sequence, Structure & Domains
Sequences
Length
1,144
Mass
128,960
Sequence
MPRNQGFSEPEYSAEYSAEYSVSLPSDPDRGVGRTHEISVRNSGSCLCLPRFMRLTFVPESLENLYQTYFKRQRHETLLVLVVFAALFDCYVVVMCAVVFSSDKLASLAVAGIGLVLDIILFVLCKKGLLPDRVTRRVLPYVLWLLITAQIFSYLGLNFARAHAASDTVGWQVFFVFSFFITLPLSLSPIVIISVVSCVVHTLVLGVTVAQQQQEELKGMQLLREILANVFLYLCAIAVGIMSYYMADRKHRKAFLEARQSLEVKMNLEEQSQQQENLMLSILPKHVADEMLKDMKKDESQKDQQQFNTMYMYRHENVSILFADIVGFTQLSSACSAQELVKLLNELFARFDKLAAKYHQLRIKILGDCYYCICGLPDYREDHAVCSILMGLAMVEAISYVREKTKTGVDMRVGVHTGTVLGGVLGQKRWQYDVWSTDVTVANKMEAGGIPGRVHISQSTMDCLKGEFDVEPGDGGSRCDYLEEKGIETYLIIASKPEVKKTATQNGLNGSALPNGAPASSKSSSPALIETKEPNGSAHSSGSTSEKPEEQDAQADNPSFPNPRRRLRLQDLADRVVDASEDEHELNQLLNEALLERESAQVVKKRNTFLLSMRFMDPEMETRYSVEKEKQSGAAFSCSCVVLLCTALVEILIDPWLMTNYVTFMVGEILLLILTICSLAAIFPRAFPKKLVAFSTWIDRTRWARNTWAMLAIFILVMANVVDMLSCLQYYTGPSNATAGMETEGSCLENPKYYNYVAVLSLIATIMLVQVSHMVKLTLMLLVAGAVATINLYAWRPVFDEYDHKRFREHDLPMVALEQMQGFNPGLNGTDRLPLVPSKYSMTVMVFLMMLSFYYFSRHVEKLARTLFLWKIEVHDQKERVYEMRRWNEALVTNMLPEHVARHFLGSKKRDEELYSQTYDEIGVMFASLPNFADFYTEESINNGGIECLRFLNEIISDFDSLLDNPKFRVITKIKTIGSTYMAASGVTPDVNTNGFASSNKEDKSERERWQHLADLADFALAMKDTLTNINNQSFNNFMLRIGMNKGGVLAGVIGARKPHYDIWGNTVNVASRMESTGVMGNIQVVEETQVILREYGFRFVRRGPIFVKGKGELLTFFLKGRDKLATFPNGPSVTLPHQVVDNS
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O60266-1; Sequence=Displayed; Name=2; IsoId=O60266-2; Sequence=VSP_055813, VSP_055814, VSP_055815
Alternative Sequence
1..389; Missing (in isoform 2); 452; G -> GGSKIEERLYSCVVAPTLRLRWE (in isoform 2); 725..770; Missing (in isoform 2)
Domain & Motif Annotations
Compositional Bias
517..527; Low complexity
Domain (CC)
The protein contains two modules with six transmembrane helices each; both are required for catalytic activity. Isolated N-terminal or C-terminal modules have no catalytic activity, but when they are brought together, enzyme activity is restored. The active site is at the interface of the two modules.
Region
504..566; Disordered
Protein Families
Adenylyl cyclase class-4/guanylyl cyclase family
Sequence Similarities
Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
Clinical Relevance
Disease Involvement
Obesity
Related Diseases
Drugs (35)
AM281CP559402-ARACHIDONOYLGLYCEROLPHOSPHOINOSITOLMANSC (415-431)LYSOPHOSPHATIDYLINOSITOLCLUL1 (52-77)ABNORMAL CANNABIDIOLSPAG11B (61-103)O-1602COMPOUND 3A [BADOLATO ET AL., 2019]CID1792197MSMB (91-114)DRONABINOLGSK494581AHU-2102-ARACHIDONYL GLYCERYL ETHERCHGB (511-532)JWH015ML193O-ARACHIDONOYL ETHANOLAMINE2-ARACHIDONOYLGLYCEROLCID1172084CP55,667CID16020046ANANDAMIDECID2440433CP55,244[3H]RIMONABANTRIMONABANTAM251GSK575594APALMIDROLCANNABIDIOLT1117N-OLEOYLETHANOLAMIDE
Supporting Publications3
| PMID | Title | Related sentences |
|---|---|---|
| 38113368 | In-Depth Proteome Profiling of Small Extracellular Vesicles Isolated from Cancer Cell Lines and Patient Serum. | No related sentences available |
| 38207106 | Proteomic, Metabolomic, and Fatty Acid Profiling of Small Extracellular Vesicles from Glioblastoma Stem-Like Cells and Their Role in Tumor Heterogeneity. | No related sentences available |
| 40189497 | Small extracellular vesicle-based one-step high-throughput microfluidic platform for epithelial ovarian cancer diagnosis. | No related sentences available |