Protein detail

SI1L3

Signal-induced proliferation-associated 1-like protein 3 (SIPA1-like protein 3) (SPA-1-like protein 3)

Entry name SI1L3	UniProt ID O60292	EVMP confidence score 0.40
Supporting publications (n) 2	Transmembrane count	Protein classification Disease related genesHuman disease related genesPredicted intracellular proteins

Basic Information

Protein Names

Signal-induced proliferation-associated 1-like protein 3 (SIPA1-like protein 3) (SPA-1-like protein 3)

Protein Class (3)

Disease related genesHuman disease related genesPredicted intracellular proteins

Protein Function (3)

Disease related genes
Predicted intracellular proteins
Human disease related genes:Nervous system diseases:Eye disease

Ensembl

ENSG00000105738

Entrez Gene Symbol

SIPA1L3

Gene Synonym (2)

KIAA0545SPAR3

Gene Description

Signal induced proliferation associated 1 like 3

Chromosome

Position

37907208-38208369

Supporting publications (n)

EVMP confidence score

0.40

Fluorescence & Localization

Tissue SpecificintestineBrain Regional Specificchoroid plexusCell SpecificBasal keratinocytesSingle-Nuclei Brain Specificcentral nervous system macrophageBlood Cell SpecificneutrophilBlood Lineage Specificgranulocytes

Function & Pathway

Protein Function (3)

Disease related genes
Predicted intracellular proteins
Human disease related genes:Nervous system diseases:Eye disease

Cellular Component (11)

Page 1 of 2

Molecular Function (2)

Biological Process (3)

KEGG

hsa04015 Rap1 signaling pathway

Mediation Categories (2)

Fusion and delivery mediationReceptor-signaling mediation

Relations & Evidence11

Ligand-Receptor Signaling (10)

10 records.

Category	Parent	Database	Transmitter	Receiver
ecm	ecm	MatrixDB	Yes
ecm	ecm	OmniPath	Yes
intracellular	intracellular	ComPPI
intracellular	intracellular	GO_Intercell
intracellular	intracellular	OmniPath
tight_junction	tight_junction	GO_Intercell	Yes	Yes
tight_junction	tight_junction	OmniPath	Yes	Yes
plasma_membrane	plasma_membrane	UniProt_location
apical_cell_membrane	plasma_membrane	UniProt_location
plasma_membrane	plasma_membrane	OmniPath

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion ChromatographyImmunoaffinity Capture	Western blottingFlow cytometryMORPH	4	38731868 40098346 37922300 41216884

Sequence, Structure & Domains

Sequences

Length

1,781

Mass

194,610

Sequence

MTTYRAIPSDGVDLAASCGARVGDVLPGPHTGDYAPLGFWAQNGSMSQPLGESPATATATATATTRPSPTTPAMPKMGVRARVADWPPKREALREHSNPSPSQDTDGTKATKMAHSMRSIQNGQPPTSTPASSGSKAFHRLSRRRSKDVEFQDGWPRSPGRAFLPLRHRSSSEITLSECDAEDAGEPRGARHTGALPLFREYGSTSSIDVQGMPEQSFFDILNEFRSEQPDARGCQALTELLRADPGPHLMGGGGGAKGDSHNGQPAKDSLLPLQPTKEKEKARKKPARGLGGGDTVDSSIFRKLRSSKPEGEAGRSPGEADEGRSPPEASRPWVCQKSFAHFDVQSMLFDLNEAAANRVSVSQRRNTTTGASAASAASAMASLTASRAHSLGGLDPAFTSTEDLNCKENLEQDLGDDNSNDLLLSCPHFRNEIGGECERNVSFSRASVGSPSSGEGHLAEPALSAYRTNASISVLEVPKEQQRTQSRPRQYSIEHVDLGARYYQDYFVGKEHANYFGVDEKLGPVAVSIKREKLEDHKEHGPQYQYRIIFRTRELITLRGSILEDATPTATKHGTGRGLPLKDALEYVIPELNIHCLRLALNTPKVTEQLLKLDEQGLCRKHKVGILYCKAGQSSEEEMYNNEEAGPAFEEFLSLIGEKVCLKGFTKYAAQLDVKTDSTGTHSLYTMYQDYEIMFHVSTLLPYTPNNRQQLLRKRHIGNDIVTIIFQEPGALPFTPKNIRSHFQHVFIIVRVHNPCTDNVCYSMAVTRSKDAPPFGPPIPSGTTFRKSDVFRDFLLAKVINAENAAHKSDKFHTMATRTRQEYLKDLAENCVSNTPIDSTGKFNLISLTSKKKEKTKARAGAEQHSAGAIAWRVVAQDYAQGVEIDCILGISNEFVVLLDLRTKEVVFNCYCGDVIGWTPDSSTLKIFYGRGDHIFLQATEGSVEDIREIVQRLKVMTSGWETVDMTLRRNGLGQLGFHVKYDGTVAEVEDYGFAWQAGLRQGSRLVEICKVAVVTLTHDQMIDLLRTSVTVKVVIIPPFEDGTPRRGWPETYDMNTSEPKTEQESITPGGRPPYRSNAPWQWSGPASHNSLPASKWATPTTPGHAQSLSRPLKQTPIVPFRESQPLHSKRPVSFPETPYTVSPAGADRVPPYRQPSGSFSTPGSATYVRYKPSPERYTAAPHPLLSLDPHFSHDGTSSGDSSSGGLTSQESTMERQKPEPLWHVPAQARLSAIAGSSGNKHPSRQDAAGKDSPNRHSKGEPQYSSHSSSNTLSSNASSSHSDDRWFDPLDPLEPEQDPLSKGGSSDSGIDTTLYTSSPSCMSLAKAPRPAKPHKPPGSMGLCGGGREAAGRSHHADRRREVSPAPAVAGQSKGYRPKLYSSGSSTPTGLAGGSRDPPRQPSDMGSRVGYPAQVYKTASAETPRPSQLAQPSPFQLSASVPKSFFSKQPVRNKHPTGWKRTEEPPPRPLPFSDPKKQVDTNTKNVFGQPRLRASLRDLRSPRKNYKSTIEDDLKKLIIMDNLGPEQERDTGQSPQKGLQRTLSDESLCSGRREPSFASPAGLEPGLPSDVLFTSTCAFPSSTLPARRQHQHPHPPVGPGATPAAGSGFPEKKSTISASELSLADGRDRPLRRLDPGLMPLPDTAAGLEWSSLVNAAKAYEVQRAVSLFSLNDPALSPDIPPAHSPVHSHLSLERGPPTPRTTPTMSEEPPLDLTGKVYQLEVMLKQLHTDLQKEKQDKVVLQSEVASLRQNNQRLQEESQAASEQLRKFAEIFCREKKEL

Domain & Motif Annotations

Compositional Bias

54..73; Low complexity; 87..97; Basic and acidic residues; 118..135; Polar residues; 137..146; Basic residues; 1080..1111; Polar residues; 1157..1166; Polar residues; 1196..1210; Low complexity; 1245..1261; Basic and acidic residues; 1266..1281; Low complexity; 1304..1322; Polar residues; 1425..1441; Polar residues; 1509..1518; Basic and acidic residues; 1532..1547; Polar residues; 1599..1609; Low complexity; 1625..1635; Basic and acidic residues

Coiled Coil

1720..1774

Domain (FT)

611..828; Rap-GAP; 966..1042; PDZ

Region

45..166; Disordered; 239..332; Disordered; 1046..1112; Disordered; 1124..1221; Disordered; 1236..1565; Disordered; 1583..1636; Disordered; 1685..1712; Disordered

Clinical Relevance

Disease Involvement

Cataract

Related Diseases

Cataract

Antibody (3)

HPA042072 HPA045480 HPA074988

Interaction Protein (4)

ENSG00000107816ENSG00000108953ENSG00000164924ENSG00000175793

Interaction Count

Interaction Dataset (4)

biogrid_bioplexbiogrid_opencellintact_biogrid_opencellintact_biogrid

Supporting Publications2

PMID	Title	Related sentences
29242380	Insights into the Proteome of Gastrointestinal Stromal Tumors-Derived Exosomes Reveals New Potential Diagnostic Biomarkers.	No related sentences available
38071653	Extracellular vesicle proteome unveils cathepsin B connection to Alzheimer's disease pathogenesis.	Extracellular vesicle proteome unveils cathepsin B connection to Alzheimer's disease pathogenesis.