Protein detail
NRP2
Neuropilin-2 (Vascular endothelial cell growth factor 165 receptor 2)
Protein symbol NRP2 | UniProt ID | EVMP score 0.38 |
Frequency 1 | Transmembrane count 1 | Protein classification Cancer-related genesPlasma proteinsPredicted membrane proteinsPredicted secreted proteinsTransporters |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Neuropilin-2 (Vascular endothelial cell growth factor 165 receptor 2)
Protein Class
Cancer-related genesPlasma proteinsPredicted membrane proteinsPredicted secreted proteinsTransporters
Protein Function
- Cancer-related genes:Candidate cancer biomarkers
- Predicted secreted proteins
- Transporters:Accessory Factors Involved in Transport
Transmembrane
865..889; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
VEGF165R2
Gene Description
Neuropilin 2
Chromosome
2
Position
205681990-205798133
Frequency
1
EVMP Score
0.38
Fluorescence & Localization
Tissue SpecificbrainCell SpecificChoroid plexus epithelial cellsSingle-Nuclei Brain SpecificoligodendrocyteBlood Cell Specificclassical monocyteBlood Lineage Specificdendritic cells
Function & Pathway
Protein Function
- Cancer-related genes:Candidate cancer biomarkers
- Predicted secreted proteins
- Transporters:Accessory Factors Involved in Transport
Cellular Component
Molecular Function
- GO:0005021 vascular endothelial growth factor receptor activity
- GO:0005515 protein binding
- GO:0008201 heparin binding
- GO:0017154 semaphorin receptor activity
- GO:0019838 growth factor binding
- GO:0019955 cytokine binding
- GO:0038023 signaling receptor activity
- GO:0042802 identical protein binding
- GO:0046872 metal ion binding
Biological Process
Reactome
Mediation Categories
Clinical-translation mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
67 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | Almen2009 | No | Yes | Yes | Yes | No |
| receptor | receptor | CellCellInteractions | No | Yes | Yes | Yes | No |
| receptor | receptor | EMBRACE | No | Yes | Yes | Yes | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | Yes | Yes | No |
| transmembrane_phobius | transmembrane_predicted | Almen2009 | No | No | Yes | Yes | No |
| transmembrane_sosui | transmembrane_predicted | Almen2009 | No | No | Yes | Yes | No |
| transmembrane_tmhmm | transmembrane_predicted | Almen2009 | No | No | Yes | Yes | No |
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Regulatory Interaction Network
5 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| SEM3C | Q99985 | NRP2 | O60462 | Yes | Yes | No | iTALKICELLNETSIGNORHPMR_talklrHPMRHPRD_LRdbtalklrHPRDRamilowski2015_Baccin2019WangRamilowski2015HPMR_LRdbCellPhoneDBHPRD_talklrBaccin2019STRING_talklrEMBRACECellTalkDBFantom5_LRdbconnectomeDB2020LRdb | CellTalkDB:10196546LRdb:93HPMR:10196546LRdb:10196546ICELLNET:29067024connectomeDB2020:9331348HPRD:9331348Baccin2019:9331348connectomeDB2020:10196546SIGNOR:16816121Baccin2019:10196546 |
| SEM3F | Q13275 | NRP2 | O60462 | Yes | Yes | No | iTALKICELLNETSIGNORHPMR_talklrHPMRHPRD_LRdbtalklrHPRDRamilowski2015_Baccin2019WangRamilowski2015HPMR_LRdbCellPhoneDBELMHPRD_talklrBaccin2019STRING_talklrEMBRACECellTalkDBFantom5_LRdbconnectomeDB2020LRdb | ELM:20387901ICELLNET:29067024LRdb:15721238Baccin2019:9883722connectomeDB2020:15721238HPMR:15721238CellTalkDB:15721238Baccin2019:15721238ICELLNET:25068647SIGNOR:16816121LRdb:99HPRD:9883722connectomeDB2020:9883722 |
| NRP2 | O60462 | VEGFC | P49767 | Yes | Yes | No | ELMSIGNOR | SIGNOR:16816121ELM:25752543 |
| VEGFC | P49767 | NRP2 | O60462 | Yes | Yes | No | iTALKICELLNETSIGNORHPMR_talklrtalklrRamilowski2015_Baccin2019WangRamilowski2015HPMR_LRdbELMBaccin2019CellinkerSTRING_talklrEMBRACECellTalkDBFantom5_LRdbHPMR_CellinkerconnectomeDB2020LRdb | Cellinker:8612600Baccin2019:8612600CellTalkDB:8612600ICELLNET:16621967LRdb:8612600SIGNOR:16816121connectomeDB2020:8612600ELM:25752543 |
| SEM3B | Q13214 | NRP2 | O60462 | Yes | Yes | No | Fantom5_LRdbCellTalkDBHPRD_LRdbiTALKtalklrSIGNORconnectomeDB2020HPRDHPRD_talklrSPIKE_LCLRdbRamilowski2015 | CellTalkDB:10196546LRdb:10196546connectomeDB2020:10196546SIGNOR:25335892HPRD:10196546SPIKE_LC:16189514 |
Protein Complex Composition
5 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| NRP2-VEGFC complex | NRP2VEGFC | O60462P49767 | 2:2 | CompleatCORUMPDB | Compleat:HC3067PDB:6tjtCORUM:5732 | 16816121 |
| NRP2-VEGFD complexheparin dependent | NRP2VEGFD | O43915O60462 | 1:1 | CompleatCORUM | Compleat:HC2455CORUM:5733 | 16816121 |
| NRP2 | O60462 | 2 | PDB | PDB:4qdsPDB:6tdbPDB:4qdqPDB:8ivwPDB:2qqo | ||
| IGHG1IGKCNRP2 | O60462P01834P01857 | 1:1:1 | PDB | PDB:2qqkPDB:2qql | ||
| NRP2VEGFA | O60462P15692 | 4:3 | PDB | PDB:5dn2 |
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometry | 1 | 30915084 |
Sequence, Structure & Domains
Sequences
Length
931
Mass
104,831
Sequence
MDMFPLTWVFLALYFSRHQVRGQPDPPCGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHDCKYDFIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEIFKTGSEDCSKNFTSPNGTIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQVGEGDCKYDWLDIWDGIPHVGPLIGKYCGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARYYLVHQEPLENFQCNVPLGMESGRIANEQISASSTYSDGRWTPQQSRLHGDDNGWTPNLDSNKEYLQVDLRFLTMLTAIATQGAISRETQNGYYVKSYKLEVSTNGEDWMVYRHGKNHKVFQANNDATEVVLNKLHAPLLTRFVRIRPQTWHSGIALRLELFGCRVTDAPCSNMLGMLSGLIADSQISASSTQEYLWSPSAARLVSSRSGWFPRIPQAQPGEEWLQVDLGTPKTVKGVIIQGARGGDSITAVEARAFVRKFKVSYSLNGKDWEYIQDPRTQQPKLFEGNMHYDTPDIRRFDPIPAQYVRVYPERWSPAGIGMRLEVLGCDWTDSKPTVETLGPTVKSEETTTPYPTEEEATECGENCSFEDDKDLQLPSGFNCNFDFLEEPCGWMYDHAKWLRTTWASSSSPNDRTFPDDRNFLRLQSDSQREGQYARLISPPVHLPRSPVCMEFQYQATGGRGVALQVVREASQESKLLWVIREDQGGEWKHGRIILPSYDMEYQIVFEGVIGKGRSGEIAIDDIRISTDVPLENCMEPISAFAGENFKVDIPEIHEREGYEDEIDDEYEVDWSNSSSATSGSGAPSTDKEKSWLYTLDPILITIIAMSSLGVLLGATCAGLLLYCTCSYSGLSSRSCTTLENYNFELYDGLKHKVKMNHQKCCSEA
Alternative Products
Event=Alternative splicing; Named isoforms=6; Name=A22; IsoId=O60462-1; Sequence=Displayed; Name=A0; IsoId=O60462-2; Sequence=VSP_004342; Name=A17; IsoId=O60462-3; Sequence=VSP_004341; Name=B0; IsoId=O60462-4; Sequence=VSP_004341, VSP_041160; Name=B5; IsoId=O60462-5; Sequence=VSP_041160; Name=s9; IsoId=O60462-6; Sequence=VSP_044908, VSP_044909
Alternative Sequence
548..555; LFEGNMHY -> VGCSWRPL (in isoform s9); 556..931; Missing (in isoform s9); 809..830; Missing (in isoform A0); 809..813; Missing (in isoform A17 and isoform B0); 814..931; VDIPEIHEREGYEDEIDDEYEVDWSNSSSATSGSGAPSTDKEKSWLYTLDPILITIIAMSSLGVLLGATCAGLLLYCTCSYSGLSSRSCTTLENYNFELYDGLKHKVKMNHQKCCSEA -> GGTLLPGTEPTVDTVPMQPIPAYWYYVMAAGGAVLVLVSVALALVLHYHRFRYAAKKTDHSITYKTSHYTNGAPLAVEPTLTIKLEQDRGSHC (in isoform B0 and isoform B5)
3D Structural Models
Turn
43..46; 163..166; 220..222; 283..285; 350..352; 440..442; 467..469; 483..485; 541..544
Helix
290..292; 306..308; 429..431; 447..449; 462..465; 515..517
Beta Strand
30..33; 38..41; 54..60; 68..72; 84..95; 98..104; 106..108; 116..125; 136..141; 151..153; 155..161; 174..180; 186..195; 210..219; 225..229; 231..233; 238..240; 242..250; 255..257; 259..267; 286..288; 293..296; 302..304; 324..326; 329..345; 355..371; 373..375; 377..380; 382..385; 388..391; 394..417; 420..428; 432..434; 443..445; 450..453; 456..459; 470..472; 477..480; 488..504; 521..534; 553..557; 559..578; 585..593
3D Structure
Electron microscopy (2); X-ray crystallography (14)
Domain & Motif Annotations
Compositional Bias
298..310; Polar residues
Domain (CC)
The tandem CUB domains mediate binding to semaphorin, while the tandem F5/8 domains are responsible for heparin and VEGF binding.
Domain (FT)
28..142; CUB 1; 149..267; CUB 2; 277..427; F5/8 type C 1; 434..592; F5/8 type C 2; 642..802; MAM
Region
298..317; Disordered; 601..622; Disordered
Protein Families
Neuropilin family
Sequence Similarities
Belongs to the neuropilin family.
Clinical Relevance
Disease Involvement
Cancer-related genes
Related Diseases
Biomarker
Phase 3