Protein detail
NMT2
Glycylpeptide N-tetradecanoyltransferase 2 (EC 2.3.1.97) (Myristoyl-CoA:protein N-myristoyltransferase 2) (NMT 2) (Peptide N-myristoyltransferase 2) (Protein-lysine myristoyltransferase NMT2) (EC 2.3.1.-) (Type II N-myristoyltransferase)
Entry name NMT2 | UniProt ID | EVMP confidence score 0.38 |
Supporting publications (n) 1 | Transmembrane count | Protein classification EnzymesMetabolic proteinsPredicted intracellular proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information10
Protein Names
Glycylpeptide N-tetradecanoyltransferase 2 (EC 2.3.1.97) (Myristoyl-CoA:protein N-myristoyltransferase 2) (NMT 2) (Peptide N-myristoyltransferase 2) (Protein-lysine myristoyltransferase NMT2) (EC 2.3.1.-) (Type II N-myristoyltransferase)
Protein Class (3)
EnzymesMetabolic proteinsPredicted intracellular proteins
Protein Function (3)
- ENZYME proteins:Transferases
- Enzymes
- Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Description
N-myristoyltransferase 2
Chromosome
10
Position
15102584-15168693
Supporting publications (n)
1
EVMP confidence score
0.38
Fluorescence & Localization4
Cell SpecificEsophageal apical cellsBlood Cell Specificintermediate monocyteBlood Lineage Specificdendritic cells
Function & Pathway7
Protein Function (3)
- ENZYME proteins:Transferases
- Enzymes
- Predicted intracellular proteins
Cellular Component (5)
Molecular Function (3)
Biological Process (3)
Reactome (10)
- R-hsa-175474 assembly of the hiv virion
- R-hsa-203615 enos activation
- R-hsa-162906 hiv infection
- R-hsa-162587 hiv life cycle
- R-hsa-5663205 infectious disease
- R-hsa-202131 metabolism of nitric oxide nos3 activation and regulation
- R-hsa-9709957 sensory perception
- R-hsa-2514856 the phototransduction cascade
- R-hsa-9824446 viral infection pathways
- R-hsa-2187338 visual phototransduction
Canonical Pathways (2)
- M268 Pid s1p s1p2 pathway
- M237 Pid vegfr1 2 pathway
Mediation Categories (3)
Clinical-translation mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence10
Ligand-Receptor Signaling (5)
5 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Protein Complex Composition (4)
4 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| HT_DM_Cluster317 | ACBD6NMT1NMT2 | O60551P30419Q9BR61 | 1:1:1 | Compleat | Compleat:HC2730 | 22036573 |
| BET1GOSR2NMT2PRKCZSAR1BSEC22BSEC23ASEC24BSTX5SURF4TMED10TMED2TMED7TMED9UBC | O14653O15155O15260O60551O75396O95487P0CG48P49755Q05513Q13190Q15363Q15436Q9BVK6Q9Y3B3Q9Y6B6 | 1:1:1:1:1:1:1:1:1:1:1:1:1:1:1 | NetworkBlastCompleat | Compleat:HC8983 | ||
| ARF6NMT2 | O60551P62330 | 1:1 | PDB | PDB:6pau | ||
| ASB6NMT2RNF7 | O60551Q9NWX5Q9UBF6 | 0:0:0 | hu.MAP2 |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass Spectrometry | 1 | 38037300 |
Sequence, Structure & Domains11
Sequences
Length
498
Mass
56,980
Sequence
MAEDSESAASQQSLELDDQDTCGIDGDNEEETEHAKGSPGGYLGAKKKKKKQKRKKEKPNSGGTKSDSASDSQEIKIQQPSKNPSVPMQKLQDIQRAMELLSACQGPARNIDEAAKHRYQFWDTQPVPKLDEVITSHGAIEPDKDNVRQEPYSLPQGFMWDTLDLSDAEVLKELYTLLNENYVEDDDNMFRFDYSPEFLLWALRPPGWLLQWHCGVRVSSNKKLVGFISAIPANIRIYDSVKKMVEINFLCVHKKLRSKRVAPVLIREITRRVNLEGIFQAVYTAGVVLPKPIATCRYWHRSLNPRKLVEVKFSHLSRNMTLQRTMKLYRLPDVTKTSGLRPMEPKDIKSVRELINTYLKQFHLAPVMDEEEVAHWFLPREHIIDTFVVESPNGKLTDFLSFYTLPSTVMHHPAHKSLKAAYSFYNIHTETPLLDLMSDALILAKSKGFDVFNALDLMENKTFLEKLKFGIGDGNLQYYLYNWRCPGTDSEKVGLVLQ
3D Structural Models
Turn
219..221; 275..277; 381..383; 463..468
Helix
122..124; 168..181; 196..203; 210..212; 254..256; 261..274; 305..310; 322..328; 345..347; 348..358; 359..361; 370..377; 433..446; 460..462; 490..492
Beta Strand
125..127; 158..162; 188..192; 213..218; 224..237; 240..252; 281..287; 293..304; 318..320; 340..342; 362..366; 384..390; 392..394; 396..404; 407..409; 416..418; 420..423; 427..431; 450..456; 470..482
3D Structure
Electron microscopy (1); X-ray crystallography (2)
Domain & Motif Annotations
Compositional Bias
15..32; Acidic residues; 45..57; Basic residues; 61..86; Polar residues
Region
1..88; Disordered
Protein Families
NMT family
Sequence Similarities
Belongs to the NMT family.
Clinical Relevance4
Antibody
Interaction Protein (3)
ENSG00000101266ENSG00000204435ENSG00000230124
Interaction Count
3
Interaction Dataset (3)
biogrid_opencellintact_biogrid_opencellintact_biogrid
Supporting Publications1
| PMID | Title | Abstract |
|---|---|---|
| 30550287 | Label-Free Proteomic Analysis of Exosomes Secreted from THP-1-Derived Macrophages Treated with IFN-α Identifies Antiviral Proteins Enriched in Exosomes. | No abstract available |