Protein detail
TLR2
Toll-like receptor 2 (Toll/interleukin-1 receptor-like protein 4) (CD antigen CD282)
Entry name TLR2 | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count 1 | Protein classification |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Toll-like receptor 2 (Toll/interleukin-1 receptor-like protein 4) (CD antigen CD282)
Protein Function
- Predicted intracellular proteins
- CD markers
- Human disease related genes:Skin diseases:Skin and soft tissue diseases
- Transporters:Accessory Factors Involved in Transport
- Human disease related genes:Immune system diseases:Allergies and autoimmune diseases
- FDA approved drug targets:Small molecule drugs
- FDA approved drug targets:Biotech drugs
Transmembrane
589..609; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Tissue Specificadipose tissueCell SpecificAdipocytesSingle-Nuclei Brain Specificdeep-layer near-projectingBlood Cell Specificclassical monocyteBlood Lineage Specificdendritic cells
Function & Pathway
Protein Function
- Predicted intracellular proteins
- CD markers
- Human disease related genes:Skin diseases:Skin and soft tissue diseases
- Transporters:Accessory Factors Involved in Transport
- Human disease related genes:Immune system diseases:Allergies and autoimmune diseases
- FDA approved drug targets:Small molecule drugs
- FDA approved drug targets:Biotech drugs
Cellular Component
- GO:0005737 cytoplasm
- GO:0005794 Golgi apparatus
- GO:0005886 plasma membrane
- GO:0009986 cell surface
- GO:0030667 secretory granule membrane
- GO:0030670 phagocytic vesicle membrane
- GO:0035354 Toll-like receptor 1-Toll-like receptor 2 protein complex
- GO:0035355 Toll-like receptor 2-Toll-like receptor 6 protein complex
- GO:0042995 cell projection
- GO:0043235 receptor complex
- GO:0044297 cell body
- GO:0045121 membrane raft
Molecular Function
- GO:0001530 lipopolysaccharide binding
- GO:0001540 amyloid-beta binding
- GO:0001875 lipopolysaccharide immune receptor activity
- GO:0004888 transmembrane signaling receptor activity
- GO:0005515 protein binding
- GO:0035325 Toll-like receptor binding
- GO:0038023 signaling receptor activity
- GO:0038187 pattern recognition receptor activity
- GO:0042497 triacyl lipopeptide binding
- GO:0042802 identical protein binding
- GO:0042834 peptidoglycan binding
- GO:0044877 protein-containing complex binding
- GO:0061809 NAD+ nucleotidase, cyclic ADP-ribose generating
Biological Process
KEGG
- hsa04145 Phagosome
- KEGG:hsa04151 PI3K-Akt signaling pathway
- KEGG:hsa04613 Neutrophil extracellular trap formation
- KEGG:hsa04620 Toll-like receptor signaling pathway
- KEGG:hsa05132 Salmonella infection
- KEGG:hsa05134 Legionellosis
- KEGG:hsa05140 Leishmaniasis
- KEGG:hsa05142 Chagas disease
- KEGG:hsa05144 Malaria
- KEGG:hsa05145 Toxoplasmosis
- KEGG:hsa05146 Amoebiasis
- KEGG:hsa05152 Tuberculosis
- KEGG:hsa05161 Hepatitis B
- KEGG:hsa05162 Measles
- KEGG:hsa05168 Herpes simplex virus 1 infection
- KEGG:hsa05169 Epstein-Barr virus infection
- KEGG:hsa05170 Human immunodeficiency virus 1 infection
- KEGG:hsa05171 Coronavirus disease
- KEGG:hsa05205 Proteoglycans in cancer
- KEGG:hsa05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
- KEGG:hsa05321 Inflammatory bowel disease
- KEGG:hsa05323 Rheumatoid arthritis
- KEGG:hsa05417 Lipid and atherosclerosis
Reactome
- R-hsa-1280218 adaptive immune system
- R-hsa-1236975 antigen processing cross presentation
- R-hsa-6803157 antimicrobial peptides
- R-hsa-9824439 bacterial infection pathways
- R-hsa-1461957 beta defensins
- R-hsa-983169 class i mhc mediated antigen processing presentation
- R-hsa-1461973 defensins
- R-hsa-5260271 diseases of immune system
- R-hsa-9635486 infection with mycobacterium tuberculosis
- R-hsa-5663205 infectious disease
- R-hsa-168249 innate immune system
- R-hsa-5603041 irak4 deficiency tlr2 4
- R-hsa-9637628 modulation by mtb of host immune system
- R-hsa-6798695 neutrophil degranulation
- R-hsa-5686938 regulation of tlr by endogenous ligand
- R-hsa-9820952 respiratory syncytial virus infection pathway
- R-hsa-9833110 rsv host interactions
- R-hsa-9705671 sars cov 2 activates modulates innate and adaptive immune responses
- R-hsa-9705683 sars cov 2 host interactions
- R-hsa-9694516 sars cov 2 infection
- R-hsa-9679506 sars cov infections
- R-hsa-168898 toll like receptor cascades
- R-hsa-168179 toll like receptor tlr1 tlr2 cascade
- R-hsa-9824446 viral infection pathways
Mediation Categories
Clinical-translation mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
57 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane | transmembrane | GO_Intercell | No | No | No | Yes | No |
| transmembrane | transmembrane | TopDB | No | No | No | Yes | No |
| transmembrane | transmembrane | LOCATE | No | No | No | Yes | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | No | Yes | No |
| transmembrane | transmembrane | OmniPath | No | No | No | Yes | No |
| plasma_membrane | plasma_membrane | Cellinker | No | No | No | Yes | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | Membranome | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | CSPA | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | HPMR | No | No | No | Yes | No |
Regulatory Interaction Network
4 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| TLR2 | O60603 | TCAM2 | Q86XR7 | Yes | Yes | No | SPIKESPIKE_LCSIGNOR | SIGNOR:22664090SPIKE_LC:20072711SPIKE:20072711 |
| TLR2 | O60603 | MYD88 | Q99836 | Yes | Yes | No | WangMacrophageSIGNORHPRDCui2007HINTIntActInnateDBSPIKE_LCLit-BM-17 | IntAct:16293622HINT:17126326SPIKE_LC:17145710InnateDB:22673208HINT:15107846InnateDB:17126326SPIKE_LC:17126326InnateDB:16482509HINT:16482509InnateDB:20348427HINT:29990310HINT:16893894IntAct:17126326IntAct:29990310InnateDB:19717524Lit-BM-17:15107846HINT:19717524Macrophage:16798732SIGNOR:22664090HPRD:16482509Lit-BM-17:17126326InnateDB:16893894 |
| TLR2 | O60603 | TIRAP | P58753 | Yes | Yes | No | SIGNORCui2007HINTInnateDBWangLit-BM-17 | Lit-BM-17:17258210Lit-BM-17:18221795SIGNOR:22664090HINT:17258210InnateDB:22673208InnateDB:19717524HINT:18221795HINT:19717524 |
| TLR2 | O60603 | TCAM1 | Q8IUC6 | Yes | Yes | No | InnateDBHPRDSIGNOR | SIGNOR:22664090InnateDB:12471095HPRD:12471095 |
Protein Complex Composition
Sequence, Structure & Domains
Sequences
Length
784
Mass
89,838
Sequence
MPHTLWMVWVLGVIISLSKEESSNQASLSCDRNGICKGSSGSLNSIPSGLTEAVKSLDLSNNRITYISNSDLQRCVNLQALVLTSNGINTIEEDSFSSLGSLEHLDLSYNYLSNLSSSWFKPLSSLTFLNLLGNPYKTLGETSLFSHLTKLQILRVGNMDTFTKIQRKDFAGLTFLEELEIDASDLQSYEPKSLKSIQNVSHLILHMKQHILLLEIFVDVTSSVECLELRDTDLDTFHFSELSTGETNSLIKKFTFRNVKITDESLFQVMKLLNQISGLLELEFDDCTLNGVGNFRASDNDRVIDPGKVETLTIRRLHIPRFYLFYDLSTLYSLTERVKRITVENSKVFLVPCLLSQHLKSLEYLDLSENLMVEEYLKNSACEDAWPSLQTLILRQNHLASLEKTGETLLTLKNLTNIDISKNSFHSMPETCQWPEKMKYLNLSSTRIHSVTGCIPKTLEILDVSNNNLNLFSLNLPQLKELYISRNKLMTLPDASLLPMLLVLKISRNAITTFSKEQLDSFHTLKTLEAGGNNFICSCEFLSFTQEQQALAKVLIDWPANYLCDSPSHVRGQQVQDVRLSVSECHRTALVSGMCCALFLLILLTGVLCHRFHGLWYMKMMWAWLQAKRKPRKAPSRNICYDAFVSYSERDAYWVENLMVQELENFNPPFKLCLHKRDFIPGKWIIDNIIDSIEKSHKTVFVLSENFVKSEWCKYELDFSHFRLFDENNDAAILILLEPIEKKAIPQRFCKLRKIMNTKTYLEWPMDEAQREGFWVNLRAAIKS
3D Structural Models
Turn
69..74; 93..98; 167..172; 191..196; 221..223; 300..302; 545..547; 717..719; 723..725; 742..744
Helix
117..120; 213..220; 263..274; 322..324; 329..334; 353..358; 374..380; 402..408; 409..411; 495..497; 518..520; 539..544; 586..611; 613..627; 649..651; 652..656; 658..663; 675..678; 685..695; 705..711; 713..716; 720..722; 726..728; 750..758; 768..770; 771..783
Beta Strand
34..37; 56..58; 80..82; 104..106; 127..130; 137..139; 153..161; 175..183; 198..206; 208..210; 224..231; 253..258; 260..262; 281..283; 288..291; 311..316; 340..346; 364..366; 391..393; 417..419; 440..442; 460..463; 481..483; 503..505; 527..529; 548..550; 641..646; 666..668; 672..674; 681..683; 696..703; 733..738; 761..763
3D Structure
NMR spectroscopy (1); X-ray crystallography (6)
Domain & Motif Annotations
Repeat
54..77; LRR 1; 78..101; LRR 2; 102..125; LRR 3; 126..150; LRR 4; 151..175; LRR 5; 176..199; LRR 6; 200..223; LRR 7; 224..250; LRR 8; 251..278; LRR 9; 279..308; LRR 10; 309..337; LRR 11; 338..361; LRR 12; 362..388; LRR 13; 389..414; LRR 14; 415..437; LRR 15; 438..457; LRR 16; 458..478; LRR 17; 479..500; LRR 18; 501..524; LRR 19
Motif
761..778; ATG16L1-binding motif
Domain (CC)
Ester-bound lipid substrates are bound through a crevice formed between the LRR 11 and LRR 12..; DOMAIN: The ATG16L1-binding motif mediates interaction with ATG16L1..
Domain (FT)
525..579; LRRCT; 639..782; TIR
Protein Families
Toll-like receptor family
Sequence Similarities
Belongs to the Toll-like receptor family.
Clinical Relevance
Related Diseases
Biomarker
Phase 2; Discontinued in Phase 1; Phase 1/2; Phase 3; Investigative
Drug Targets
Clinical trial targetPatented-recorded targetSuccessful target
Drugs
Interaction Protein
ENSG00000146648
Interaction Count
1
Interaction Dataset
intact_biogrid