Protein detail
GFRA3
GDNF family receptor alpha-3 (GDNF receptor alpha-3) (GDNFR-alpha-3) (GFR-alpha-3)
Protein symbol GFRA3 | UniProt ID | EVMP score 0.50 |
Frequency 3 | Transmembrane count | Protein classification Predicted membrane proteins |
Basic Information
Protein Names
GDNF family receptor alpha-3 (GDNF receptor alpha-3) (GDNFR-alpha-3) (GFR-alpha-3)
Protein Class
Predicted membrane proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
GFRa-3
Gene Description
GDNF family receptor alpha 3
Chromosome
5
Position
138252380-138274621
Frequency
3
EVMP Score
0.50
Fluorescence & Localization
Tissue Specificskeletal muscleCell SpecificCardiomyocytes
Function & Pathway
Cellular Component
Molecular Function
Biological Process
Reactome
Mediation Categories
Clinical-translation mediationFusion and delivery mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
44 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| growth_factor | receptor | ICELLNET | No | Yes | No | No | No |
| growth_factor_gdnf_family | receptor | ICELLNET | No | Yes | No | No | No |
| receptor | receptor | OmniPath | No | Yes | No | No | No |
| extracellular | extracellular | HPMR | No | No | No | No | No |
| extracellular | extracellular | DGIdb | No | No | No | No | No |
| extracellular | extracellular | OmniPath | No | No | No | No | No |
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
1 record.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| ARTN | Q5T4W7 | GFRA3 | O60609 | Yes | Yes | No | iTALKSIGNORHINTUniProt_LRdbDIPLit-BM-17HPMR_talklrHPMRHPRD_LRdbtalklrHPRDRamilowski2015_Baccin2019IntActWangRamilowski2015HPMR_LRdbReactome_LRdbHPRD_talklrBaccin2019CellinkerSTRING_talklrFantom5_LRdbCellTalkDBHPMR_CellinkerconnectomeDB2020LRdb | HPRD:9883723connectomeDB2020:9883723Cellinker:11544105IntAct:16765900LRdb:9883723HPMR:9883723HINT:9883723Lit-BM-17:16765900Lit-BM-17:9883723HINT:31535977DIP:16765900SIGNOR:9883723Cellinker:9883723Baccin2019:98837239883723HINT:16765900CellTalkDB:9883723 |
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Ultrafiltration / Tangential Flow FiltrationSize Exclusion Chromatography | Mass spectrometry [MALDI TOF]|Western blottingWestern blotting|Immunoelectron MicroscopyFACSMass spectrometry | 1 | 12519789 |
Sequence, Structure & Domains
Sequences
Length
400
Mass
44,511
Sequence
MVRPLNPRPLPPVVLMLLLLLPPSPLPLAAGDPLPTESRLMNSCLQARRKCQADPTCSAAYHHLDSCTSSISTPLPSEEPSVPADCLEAAQQLRNSSLIGCMCHRRMKNQVACLDIYWTVHRARSLGNYELDVSPYEDTVTSKPWKMNLSKLNMLKPDSDLCLKFAMLCTLNDKCDRLRKAYGEACSGPHCQRHVCLRQLLTFFEKAAEPHAQGLLLCPCAPNDRGCGERRRNTIAPNCALPPVAPNCLELRRLCFSDPLCRSRLVDFQTHCHPMDILGTCATEQSRCLRAYLGLIGTAMTPNFVSNVNTSVALSCTCRGSGNLQEECEMLEGFFSHNPCLTEAIAAKMRFHSQLFSQDWPHPTFAVMAHQNENPAVRPQPWVPSLFSCTLPLILLLSLW
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O60609-1; Sequence=Displayed; Name=2; IsoId=O60609-2; Sequence=VSP_010942
Alternative Sequence
127..157; Missing (in isoform 2)
3D Structural Models
Turn
188..190; 294..297
Helix
161..170; 173..185; 193..206; 209..216; 225..233; 237..240; 248..256; 259..271; 285..293; 322..324; 325..336; 339..355
Beta Strand
274..276; 281..283; 302..304; 307..309; 312..315
3D Structure
Electron microscopy (1); X-ray crystallography (1)
Domain & Motif Annotations
Protein Families
GDNFR family
Sequence Similarities
Belongs to the GDNFR family.