Protein detail
GFRA3
GDNF family receptor alpha-3 (GDNF receptor alpha-3) (GDNFR-alpha-3) (GFR-alpha-3)
Entry name GFRA3 | UniProt ID | EVMP confidence score 0.50 |
Supporting publications (n) 3 | Transmembrane count | Protein classification Predicted membrane proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information10
Protein Names
GDNF family receptor alpha-3 (GDNF receptor alpha-3) (GDNFR-alpha-3) (GFR-alpha-3)
Protein Class
Predicted membrane proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
GFRa-3
Gene Description
GDNF family receptor alpha 3
Chromosome
5
Position
138252380-138274621
Supporting publications (n)
3
EVMP confidence score
0.50
Fluorescence & Localization3
Tissue Specificskeletal muscleCell SpecificCardiomyocytes
Function & Pathway5
Cellular Component (5)
Molecular Function (5)
Biological Process (3)
Reactome (4)
Mediation Categories (3)
Clinical-translation mediationFusion and delivery mediationReceptor-signaling mediation
Relations & Evidence47
Ligand-Receptor Signaling (44)
44 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| growth_factor | receptor | ICELLNET | No | Yes | No | No | No |
| growth_factor_gdnf_family | receptor | ICELLNET | No | Yes | No | No | No |
| receptor | receptor | OmniPath | No | Yes | No | No | No |
| extracellular | extracellular | HPMR | No | No | No | No | No |
| extracellular | extracellular | DGIdb | No | No | No | No | No |
| extracellular | extracellular | OmniPath | No | No | No | No | No |
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Regulatory Interaction Network (1)
1 record.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| ARTN | Q5T4W7 | GFRA3 | O60609 | Yes | Yes | No | iTALKSIGNORHINTUniProt_LRdbDIPLit-BM-17HPMR_talklrHPMRHPRD_LRdbtalklrHPRDRamilowski2015_Baccin2019IntActWangRamilowski2015HPMR_LRdbReactome_LRdbHPRD_talklrBaccin2019CellinkerSTRING_talklrFantom5_LRdbCellTalkDBHPMR_CellinkerconnectomeDB2020LRdb | HPRD:9883723connectomeDB2020:9883723Cellinker:11544105IntAct:16765900LRdb:9883723HPMR:9883723HINT:9883723Lit-BM-17:16765900Lit-BM-17:9883723HINT:31535977DIP:16765900SIGNOR:9883723Cellinker:9883723Baccin2019:98837239883723HINT:16765900CellTalkDB:9883723 |
Protein Complex Composition (1)
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Ultrafiltration / Tangential Flow FiltrationSize Exclusion Chromatography | Mass spectrometry [MALDI TOF]|Western blottingWestern blotting|Immunoelectron MicroscopyFACSMass spectrometry | 1 | 12519789 |
Sequence, Structure & Domains11
Sequences
Length
400
Mass
44,511
Sequence
MVRPLNPRPLPPVVLMLLLLLPPSPLPLAAGDPLPTESRLMNSCLQARRKCQADPTCSAAYHHLDSCTSSISTPLPSEEPSVPADCLEAAQQLRNSSLIGCMCHRRMKNQVACLDIYWTVHRARSLGNYELDVSPYEDTVTSKPWKMNLSKLNMLKPDSDLCLKFAMLCTLNDKCDRLRKAYGEACSGPHCQRHVCLRQLLTFFEKAAEPHAQGLLLCPCAPNDRGCGERRRNTIAPNCALPPVAPNCLELRRLCFSDPLCRSRLVDFQTHCHPMDILGTCATEQSRCLRAYLGLIGTAMTPNFVSNVNTSVALSCTCRGSGNLQEECEMLEGFFSHNPCLTEAIAAKMRFHSQLFSQDWPHPTFAVMAHQNENPAVRPQPWVPSLFSCTLPLILLLSLW
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O60609-1; Sequence=Displayed; Name=2; IsoId=O60609-2; Sequence=VSP_010942
Alternative Sequence
127..157; Missing (in isoform 2)
3D Structural Models
Turn
188..190; 294..297
Helix
161..170; 173..185; 193..206; 209..216; 225..233; 237..240; 248..256; 259..271; 285..293; 322..324; 325..336; 339..355
Beta Strand
274..276; 281..283; 302..304; 307..309; 312..315
3D Structure
Electron microscopy (1); X-ray crystallography (1)
Domain & Motif Annotations
Protein Families
GDNFR family
Sequence Similarities
Belongs to the GDNFR family.
Supporting Publications3
| PMID | Title | Abstract |
|---|---|---|
| 32384937 | Alzheimer's disease progression characterized by alterations in the molecular profiles and biogenesis of brain extracellular vesicles. | No abstract available |
| 32795414 | Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers. | Among traditional exosome markers, CD9, HSPA8, ALIX, and HSP90AB1 represent pan-EVP markers, while ACTB, MSN, and RAP1B are novel pan-EVP markers. |
| 38321535 | Identification of specific markers for human pluripotent stem cell-derived small extracellular vesicles. | No abstract available |