Protein detail
DIAP1
Protein diaphanous homolog 1 (Diaphanous-related formin-1) (DRF1)
Entry name DIAP1 | UniProt ID | EVMP confidence score 0.53 |
Supporting publications (n) 2 | Transmembrane count | Protein classification Cancer-related genesDisease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteins |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Protein diaphanous homolog 1 (Diaphanous-related formin-1) (DRF1)
Protein Class (5)
Cancer-related genesDisease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteins
Protein Function (5)
- Human disease related genes:Cardiovascular diseases:Hematologic diseases
- Predicted intracellular proteins
- Cancer-related genes:Mutated cancer genes
- Disease related genes
- Human disease related genes:Nervous system diseases:Ear disease
Ensembl
Entrez Gene Symbol
Gene Synonym (4)
DFNA1hDIA1LFHL1mDia1
Gene Description
Diaphanous related formin 1
Chromosome
5
Position
141515016-141619055
Supporting publications (n)
2
EVMP confidence score
0.53
Fluorescence & Localization
Tissue Specificbone marrowCell SpecificcDCSingle-Nuclei Brain SpecificCGE interneuron
Function & Pathway
Protein Function (5)
- Human disease related genes:Cardiovascular diseases:Hematologic diseases
- Predicted intracellular proteins
- Cancer-related genes:Mutated cancer genes
- Disease related genes
- Human disease related genes:Nervous system diseases:Ear disease
Cellular Component (10)
Molecular Function (6)
Biological Process (3)
KEGG (5)
Reactome (16)
- R-hsa-6785631 erbb2 regulates cell motility
- R-hsa-168249 innate immune system
- R-hsa-9856651 mitf m dependent gene expression
- R-hsa-9730414 mitf m regulated melanocyte development
- R-hsa-6798695 neutrophil degranulation
- R-hsa-8980692 rhoa gtpase cycle
- R-hsa-9013026 rhob gtpase cycle
- R-hsa-9013106 rhoc gtpase cycle
- R-hsa-9013405 rhod gtpase cycle
- R-hsa-9035034 rhof gtpase cycle
Page 1 of 2
Mediation Categories (4)
Fusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence17
Enzyme-Mediated Modification (1)
1 record.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| DIAPH1 | CDK1 | P06493 | T | 768 | phosphorylation | PhosphoSite_MIMPMIMPProtMapperPhosphoSitePhosphoSite_ProtMapper |
Ligand-Receptor Signaling (7)
7 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | |||||
| intracellular | intracellular | ComPPI | |||||
| intracellular | intracellular | GO_Intercell | |||||
| intracellular | intracellular | UniProt_location | |||||
| intracellular | intracellular | OmniPath | |||||
| plasma_membrane | plasma_membrane | UniProt_location | |||||
| plasma_membrane | plasma_membrane | OmniPath |
Regulatory Interaction Network (4)
4 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| RHOA | P61586 | DIAP1 | O60610 | Yes | Yes | WangSIGNORHPRDCui2007HINTIntActSPIKE_LCLit-BM-17SPIKE | SPIKE:16109481IntAct:18218625SPIKE:15864301HINT:12773565SPIKE_LC:16109481HPRD:15864301SIGNOR:22820501HINT:18218625SPIKE_LC:15864301Lit-BM-17:12773565HPRD:16109481 | |
| CDK1 | P06493 | DIAP1 | O60610 | Yes | Yes | PhosphoSite_MIMPMIMPPhosphoSite_norefSIGNORiPTMnetProtMapperPhosphoSite_ProtMapper | SIGNOR:30816115 | |
| CHK1 | O14757 | DIAP1 | O60610 | Yes | Yes | SIGNOR | SIGNOR:28697335 | |
| DIAP1 | O60610 | CADH4 | P55283 | Yes | Yes | SIGNOR | SIGNOR:22820501 |
Protein Complex Composition (4)
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometry | 1 | 31805958 |
Sequence, Structure & Domains
Sequences
Length
1,272
Mass
141,347
Sequence
MEPPGGSLGPGRGTRDKKKGRSPDELPSAGGDGGKSKKFTLKRLMADELERFTSMRIKKEKEKPNSAHRNSSASYGDDPTAQSLQDVSDEQVLVLFEQMLLDMNLNEEKQQPLREKDIIIKREMVSQYLYTSKAGMSQKESSKSAMMYIQELRSGLRDMPLLSCLESLRVSLNNNPVSWVQTFGAEGLASLLDILKRLHDEKEETAGSYDSRNKHEIIRCLKAFMNNKFGIKTMLETEEGILLLVRAMDPAVPNMMIDAAKLLSALCILPQPEDMNERVLEAMTERAEMDEVERFQPLLDGLKSGTTIALKVGCLQLINALITPAEELDFRVHIRSELMRLGLHQVLQDLREIENEDMRVQLNVFDEQGEEDSYDLKGRLDDIRMEMDDFNEVFQILLNTVKDSKAEPHFLSILQHLLLVRNDYEARPQYYKLIEECISQIVLHKNGADPDFKCRHLQIEIEGLIDQMIDKTKVEKSEAKAAELEKKLDSELTARHELQVEMKKMESDFEQKLQDLQGEKDALHSEKQQIATEKQDLEAEVSQLTGEVAKLTKELEDAKKEMASLSAAAITVPPSVPSRAPVPPAPPLPGDSGTIIPPPPAPGDSTTPPPPPPPPPPPPPLPGGVCISSPPSLPGGTAISPPPPLSGDATIPPPPPLPEGVGIPSPSSLPGGTAIPPPPPLPGSARIPPPPPPLPGSAGIPPPPPPLPGEAGMPPPPPPLPGGPGIPPPPPFPGGPGIPPPPPGMGMPPPPPFGFGVPAAPVLPFGLTPKKLYKPEVQLRRPNWSKLVAEDLSQDCFWTKVKEDRFENNELFAKLTLTFSAQTKTSKAKKDQEGGEEKKSVQKKKVKELKVLDSKTAQNLSIFLGSFRMPYQEIKNVILEVNEAVLTESMIQNLIKQMPEPEQLKMLSELKDEYDDLAESEQFGVVMGTVPRLRPRLNAILFKLQFSEQVENIKPEIVSVTAACEELRKSESFSNLLEITLLVGNYMNAGSRNAGAFGFNISFLCKLRDTKSTDQKMTLLHFLAELCENDYPDVLKFPDELAHVEKASRVSAENLQKNLDQMKKQISDVERDVQNFPAATDEKDKFVEKMTSFVKDAQEQYNKLRMMHSNMETLYKELGEYFLFDPKKLSVEEFFMDLHNFRNMFLQAVKENQKRRETEEKMRRAKLAKEKAEKERLEKQQKREQLIDMNAEGDETGVMDSLLEALQSGAAFRRKRGPRQANRKAGCAVTSLLASELTKDDAMAAVPAKVSKNSETFPTILEEAKELVGRAS
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=O60610-1; Sequence=Displayed; Name=2; IsoId=O60610-2; Sequence=VSP_035870, VSP_035871, VSP_035872; Name=3; IsoId=O60610-3; Sequence=VSP_035870
Alternative Sequence
40..48; Missing (in isoform 2 and isoform 3); 621..632; Missing (in isoform 2); 826..828; Missing (in isoform 2)
3D Structural Models
Turn
153..155; 272..274
Helix
145..152; 158..174; 177..200; 203..205; 210..224; 228..235; 240..246; 253..267; 275..289; 296..299; 308..322; 328..340; 343..350; 356..377; 1198..1207; 1210..1212
3D Structure
NMR spectroscopy (1)
Domain & Motif Annotations
Compositional Bias
1..12; Gly residues; 44..65; Basic and acidic residues; 67..84; Polar residues; 574..589; Pro residues; 596..622; Pro residues; 640..658; Pro residues; 659..674; Low complexity; 675..753; Pro residues
Coiled Coil
468..572; 1039..1196
Domain (CC)
The DAD domain regulates activation via by an autoinhibitory interaction with the GBD/FH3 domain (By similarity). This autoinhibition is released upon competitive binding of an activated GTPase (By similarity). The release of DAD allows the FH2 domain to then nucleate and elongate nonbranched actin filaments (By similarity).
Domain (FT)
84..449; GBD/FH3; 583..764; FH1; 769..1171; FH2; 1194..1222; DAD
Region
1..84; Disordered; 573..755; Disordered
Protein Families (2)
- Formin homology family
- Diaphanous subfamily
Sequence Similarities
Belongs to the formin homology family. Diaphanous subfamily.
Clinical Relevance
Disease Involvement (5)
Cancer-related genesDeafnessDisease variantEpilepsyNon-syndromic deafness
Related Diseases (3)
Interaction Protein (4)
ENSG00000067560ENSG00000155366ENSG00000173156ENSG00000198142
Interaction Count
4
Interaction Dataset (2)
intact_biogridbiogrid_opencell
Supporting Publications2
| PMID | Title | Related sentences |
|---|---|---|
| 31753726 | Serum extracellular vesicles contain SPARC and LRG1 as biomarkers of colon cancer and differ by tumour primary location. | No related sentences available |
| 36028467 | Plasma exosomal DOK3 reflects immunological states in lung tumor and predicts prognosis of gefitinib treatment. | No related sentences available |