Protein detail
TSN1
Tetraspanin-1 (Tspan-1) (Tetraspan NET-1) (Tetraspanin TM4-C)
Entry name TSN1 | UniProt ID | EVMP confidence score 0.25 |
Supporting publications (n) 2 | Transmembrane count 4 | Protein classification Predicted membrane proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information12
Protein Names
Tetraspanin-1 (Tspan-1) (Tetraspan NET-1) (Tetraspanin TM4-C)
Protein Class
Predicted membrane proteins
Transmembrane
12..32; Helical; 53..73; Helical; 89..109; Helical; 212..232; Helical
Transmembrane Count
4
Ensembl
Entrez Gene Symbol
Gene Synonym (2)
NET-1TSPAN-1
Gene Description
Tetraspanin 1
Chromosome
1
Position
46175073-46185962
Supporting publications (n)
2
EVMP confidence score
0.25
Fluorescence & Localization2
Tissue SpecificbrainCell SpecificCone photoreceptor cells
Function & Pathway4
Cellular Component (10)
Molecular Function
Biological Process (3)
Mediation Categories
Fusion and delivery mediation
Relations & Evidence50
Ligand-Receptor Signaling (43)
43 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | OmniPath | No | No | No | Yes | No |
| cell_surface | cell_surface | Surfaceome | No | No | No | Yes | No |
| cell_surface | cell_surface | connectomeDB2020 | No | No | No | Yes | No |
| cell_surface | cell_surface | OmniPath | No | No | No | Yes | No |
| ligand | ligand | ICELLNET | Yes | No | No | Yes | No |
| cell_adhesion | ligand | ICELLNET | Yes | No | No | Yes | No |
| ligand | ligand | OmniPath | Yes | No | No | Yes | No |
| receptor | receptor | talklr | No | Yes | No | Yes | No |
| receptor | receptor | Cellinker | No | Yes | No | Yes | No |
| receptor | receptor | connectomeDB2020 | No | Yes | No | Yes | No |
Protein Complex Composition (6)
6 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| SCF E3 ubiquitin ligase complexTSPAN17 variant | CUL1RBX1SKP1TSPAN17 | P62877P63208Q13616Q96FV3 | 1:1:1:1 | ComplexPortal | intact:EBI-46418128PDB:1LDJ | 14755292353012431552027734445249 |
| TSPAN15 | O95858 | 2 | PDB | PDB:7rdbPDB:7rd5 | ||
| FAM241BTSPAN15 | O95858Q96D05 | 0:0 | hu.MAP | |||
| BSCL2CES3GABRETMEM25TSPAN17 | P78334Q6UWW8Q86YD3Q96FV3Q96G97 | 0:0:0:0:0 | hu.MAP2 | |||
| TM2D1TMT1ATSPAN17 | Q96FV3Q9BX74Q9H8H3 | 0:0:0 | hu.MAP2 | |||
| TMT1ATSPAN17 | Q96FV3Q9H8H3 | 0:0 | hu.MAPhu.MAP2 |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion Chromatography | NA | 1 | 37941517 |
Sequence, Structure & Domains5
Sequences
Length
241
Mass
26,301
Sequence
MQCFSFIKTMMILFNLLIFLCGAALLAVGIWVSIDGASFLKIFGPLSSSAMQFVNVGYFLIAAGVVVFALGFLGCYGAKTESKCALVTFFFILLLIFIAEVAAAVVALVYTTMAEHFLTLLVVPAIKKDYGSQEDFTQVWNTTMKGLKCCGFTNYTDFEDSPYFKENSAFPPFCCNDNVTNTANETCTKQKAHDQKVEGCFNQLLYDIRTNAVTVGGVAAGIGGLELAAMIVSMYLYCNLQ
Domain & Motif Annotations
Protein Families
Tetraspanin (TM4SF) family
Sequence Similarities
Belongs to the tetraspanin (TM4SF) family.
Clinical Relevance1
Antibody
Supporting Publications2
| PMID | Title | Abstract |
|---|---|---|
| 30608700 | Quantitative Proteomic Analysis of Small and Large Extracellular Vesicles (EVs) Reveals Enrichment of Adhesion Proteins in Small EVs. | No abstract available |
| 40098346 | Toward Identification of Markers for Brain-Derived Extracellular Vesicles in Cerebrospinal Fluid: A Large-Scale, Unbiased Analysis Using Proximity Extension Assays. | No abstract available |