Protein detail
EXOC3
Exocyst complex component 3 (Exocyst complex component Sec6)
Entry name EXOC3 | UniProt ID | EVMP score 0.38 |
Frequency 2 | Transmembrane count | Protein classification |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Exocyst complex component 3 (Exocyst complex component Sec6)
Protein Function
- Transporters:Transporter channels and pores
- Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Frequency
2
EVMP Score
0.38
Fluorescence & Localization
Cell SpecificChoroid plexus epithelial cells
Function & Pathway
Protein Function
- Transporters:Transporter channels and pores
- Predicted intracellular proteins
Cellular Component
Biological Process
Reactome
- R-hsa-5620920 cargo trafficking to the periciliary membrane
- R-hsa-5617833 cilium assembly
- R-hsa-264876 insulin processing
- R-hsa-199991 membrane trafficking
- R-hsa-1852241 organelle biogenesis and maintenance
- R-hsa-2980736 peptide hormone metabolism
- R-hsa-1445148 translocation of slc2a4 glut4 to the plasma membrane
- R-hsa-5653656 vesicle mediated transport
- R-hsa-5620916 vxpx cargo targeting to cilium
Mediation Categories
Fusion and delivery mediationMetabolism mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
4 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
0 records.
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometry | 1 | 31805958 |
Sequence, Structure & Domains
Sequences
Length
745
Mass
85,567
Sequence
MKETDREAVATAVQRVAGMLQRPDQLDKVEQYRRREARKKASVEARLKAAIQSQLDGVRTGLSQLHNALNDVKDIQQSLADVSKDWRQSINTIESLKDVKDAVVQHSQLAAAVENLKNIFSVPEIVRETQDLIEQGALLQAHRKLMDLECSRDGLMYEQYRMDSGNTRDMTLIHGYFGSTQGLSDELAKQLWMVLQRSLVTVRRDPTLLVSVVRIIEREEKIDRRILDRKKQTGFVPPGRPKNWKEKMFTILERTVTTRIEGTQADTRESDKMWLVRHLEIIRKYVLDDLIVAKNLMVQCFPPHYEIFKNLLNMYHQALSTRMQDLASEDLEANEIVSLLTWVLNTYTSTEMMRNVELAPEVDVGTLEPLLSPHVVSELLDTYMSTLTSNIIAWLRKALETDKKDWVKETEPEADQDGYYQTTLPAIVFQMFEQNLQVAAQISEDLKTKVLVLCLQQMNSFLSRYKDEAQLYKEEHLRNRQHPHCYVQYMIAIINNCQTFKESIVSLKRKYLKNEVEEGVSPSQPSMDGILDAIAKEGCSGLLEEVFLDLEQHLNELMTKKWLLGSNAVDIICVTVEDYFNDFAKIKKPYKKRMTAEAHRRVVVEYLRAVMQKRISFRSPEERKEGAEKMVREAEQLRFLFRKLASGFGEDVDGYCDTIVAVAEVIKLTDPSLLYLEVSTLVSKYPDIRDDHIGALLAVRGDASRDMKQTIMETLEQGPAQASPSYVPLFKDIVVPSLNVAKLLK
3D Structural Models
Domain & Motif Annotations
Protein Families
SEC6 family
Sequence Similarities
Belongs to the SEC6 family.
Clinical Relevance
Interaction Protein
ENSG00000070367ENSG00000090989ENSG00000112685ENSG00000116903ENSG00000131558ENSG00000138190ENSG00000144036ENSG00000182473
Interaction Count
8
Interaction Dataset
intact_biogrid