Protein detail

FCMR

Immunoglobulin mu Fc receptor (IgM FcR) (Fas apoptotic inhibitory molecule 3) (FAIM3) (Regulator of Fas-induced apoptosis Toso)

Entry name FCMR	UniProt ID O60667	EVMP confidence score 0.38
Supporting publications (n) 2	Transmembrane count 1	Protein classification Predicted intracellular proteinsPredicted membrane proteinsPredicted secreted proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Immunoglobulin mu Fc receptor (IgM FcR) (Fas apoptotic inhibitory molecule 3) (FAIM3) (Regulator of Fas-induced apoptosis Toso)

Protein Class (3)

Predicted intracellular proteinsPredicted membrane proteinsPredicted secreted proteins

Protein Function (2)

Predicted secreted proteins
Predicted intracellular proteins

Transmembrane

252..272; Helical

Transmembrane Count

Ensembl

ENSG00000162894

Entrez Gene Symbol

FCMR

Gene Synonym (3)

FAIM3FcmuRTOSO

Gene Description

Fc mu receptor

Chromosome

Position

206903317-206923247

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization4

Tissue SpecificpancreasCell SpecificLoop of henle epithelial cellsSingle-Nuclei Brain SpecificMGE interneuron

Function & Pathway6

Protein Function (2)

Predicted secreted proteins
Predicted intracellular proteins

Cellular Component (5)

Molecular Function (5)

Biological Process (3)

Canonical Pathways

M83 Pid cdc42 reg pathway

Mediation Categories (3)

Adhesion and uptake mediationFusion and delivery mediationImmune mediation

Relations & Evidence34

Ligand-Receptor Signaling (28)

28 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
secreted	secreted	HPA_secretome	No	No	Yes	Yes	No
secreted	secreted	OmniPath	No	No	Yes	Yes	No
cell_surface	cell_surface	OmniPath	No	No	Yes	Yes	No
receptor	receptor	scConnect	No	Yes	Yes	Yes	No
receptor	receptor	Almen2009	No	Yes	Yes	Yes	No
transmembrane	transmembrane_predicted	Phobius	No	No	Yes	Yes	No
transmembrane_phobius	transmembrane_predicted	Almen2009	No	No	Yes	Yes	No
transmembrane_tmhmm	transmembrane_predicted	Almen2009	No	No	Yes	Yes	No

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Protein Complex Composition (5)

5 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
FCMR	O60667	2	PDB	PDB:7yte
FCMR JCHAIN	O60667 P01591	8:1	PDB	PDB:8bpe
FCMR IGHM JCHAIN PIGR	O60667 P01591 P01833 P01871	4:1:1:10	PDB	PDB:7ysg
FCMR IGHM JCHAIN	O60667 P01591 P01871	1:1:10	PDB	PDB:7ytcPDB:8bpfPDB:7ytd
FCMR IGHM	O60667 P01871	2:4	PDB	PDB:8bpg

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion ChromatographyImmunoaffinity Capture	Western blottingFlow cytometryMORPH	5	38731868 40098346 41216884 30451371 31320591

Sequence, Structure & Domains13

Sequences

Length

390

Mass

43,146

Sequence

MDFWLWPLYFLPVSGALRILPEVKVEGELGGSVTIKCPLPEMHVRIYLCREMAGSGTCGTVVSTTNFIKAEYKGRVTLKQYPRKNLFLVEVTQLTESDSGVYACGAGMNTDRGKTQKVTLNVHSEYEPSWEEQPMPETPKWFHLPYLFQMPAYASSSKFVTRVTTPAQRGKVPPVHHSSPTTQITHRPRVSRASSVAGDKPRTFLPSTTASKISALEGLLKPQTPSYNHHTRLHRQRALDYGSQSGREGQGFHILIPTILGLFLLALLGLVVKRAVERRKALSRRARRLAVRMRALESSQRPRGSPRPRSQNNIYSACPRRARGADAAGTGEAPVPGPGAPLPPAPLQVSESPWLHAPSLKTSCEYVSLYHQPAAMMEDSDSDDYINVPA

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=O60667-1; Sequence=Displayed; Name=2; IsoId=O60667-2; Sequence=VSP_042947; Name=3; IsoId=O60667-3; Sequence=VSP_045188, VSP_045189

Alternative Sequence

13..124; Missing (in isoform 2); 237..245; RALDYGSQS -> SPLQAGPPT (in isoform 3); 249..390; GQGFHILIPTILGLFLLALLGLVVKRAVERRKALSRRARRLAVRMRALESSQRPRGSPRPRSQNNIYSACPRRARGADAAGTGEAPVPGPGAPLPPAPLQVSESPWLHAPSLKTSCEYVSLYHQPAAMMEDSDSDDYINVPA -> DARPGELPEAPRVAATALPKQHLQRLPAARSWSGRCRHRGGPRSRPRSAVAPRPAAGV (in isoform 3)

3D Structural Models

Turn

53..55; 64..66

Helix

70..72; 82..84; 96..98

Beta Strand

22..28; 33..38; 46..51; 57..63; 75..81; 86..91; 100..108; 110..123

3D Structure

Electron microscopy (6); X-ray crystallography (1)

Domain & Motif Annotations

Compositional Bias

293..311; Low complexity; 325..334; Low complexity; 335..346; Pro residues

Domain (CC)

The Ig-like V-set domain comprises three loops analogous to the complementarity-determining regions (CDR) of Ig variable domains, which are responsible for engaging IgM. Mediates multivalent interactions with the CH4 domains of pentameric IgM, facilitating receptor clustering and signaling.

Domain (FT)

23..123; Ig-like

Region

33..115; CDR4; 40..45; CDR1; 59..70; CDR2; 106..115; CDR3; 166..204; Disordered; 293..348; Disordered

Clinical Relevance1

Antibody

HPA003910

Supporting Publications2

PMID	Title	Abstract
33709510	Unbiased proteomic profiling of host cell extracellular vesicle composition and dynamics upon HIV-1 infection.	No abstract available
40748658	Exosomes released from senescent cells and circulatory exosomes isolated from human plasma reveal aging-associated proteomic and lipid signatures.	No abstract available