Protein detail

FCMR

Immunoglobulin mu Fc receptor (IgM FcR) (Fas apoptotic inhibitory molecule 3) (FAIM3) (Regulator of Fas-induced apoptosis Toso)

Entry name FCMR	UniProt ID O60667	EVMP score 0.38
Frequency 2	Transmembrane count 1	Protein classification Predicted intracellular proteinsPredicted membrane proteinsPredicted secreted proteins

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Immunoglobulin mu Fc receptor (IgM FcR) (Fas apoptotic inhibitory molecule 3) (FAIM3) (Regulator of Fas-induced apoptosis Toso)

Protein Class

Predicted intracellular proteinsPredicted membrane proteinsPredicted secreted proteins

Protein Function

Predicted secreted proteins
Predicted intracellular proteins

Transmembrane

252..272; Helical

Transmembrane Count

Ensembl

ENSG00000162894

Entrez Gene Symbol

FCMR

Gene Synonym

FAIM3FcmuRTOSO

Gene Description

Fc mu receptor

Chromosome

Position

206903317-206923247

Frequency

EVMP Score

0.38

Fluorescence & Localization

Tissue SpecificpancreasCell SpecificLoop of henle epithelial cellsSingle-Nuclei Brain SpecificMGE interneuron

Function & Pathway

Protein Function

Predicted secreted proteins
Predicted intracellular proteins

Cellular Component

Molecular Function

Biological Process

Canonical Pathways

M83 Pid cdc42 reg pathway

Mediation Categories

Adhesion and uptake mediationFusion and delivery mediationImmune mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

28 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
secreted	secreted	HPA_secretome	No	No	Yes	Yes	No
secreted	secreted	OmniPath	No	No	Yes	Yes	No
cell_surface	cell_surface	OmniPath	No	No	Yes	Yes	No
receptor	receptor	scConnect	No	Yes	Yes	Yes	No
receptor	receptor	Almen2009	No	Yes	Yes	Yes	No
transmembrane	transmembrane_predicted	Phobius	No	No	Yes	Yes	No
transmembrane_phobius	transmembrane_predicted	Almen2009	No	No	Yes	Yes	No
transmembrane_tmhmm	transmembrane_predicted	Almen2009	No	No	Yes	Yes	No

Page 3 of 3Previous

Regulatory Interaction Network

0 records.

Protein Complex Composition

5 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
FCMR	O60667	2	PDB	PDB:7yte
FCMR JCHAIN	O60667 P01591	8:1	PDB	PDB:8bpe
FCMR IGHM JCHAIN PIGR	O60667 P01591 P01833 P01871	4:1:1:10	PDB	PDB:7ysg
FCMR IGHM JCHAIN	O60667 P01591 P01871	1:1:10	PDB	PDB:7ytcPDB:8bpfPDB:7ytd
FCMR IGHM	O60667 P01871	2:4	PDB	PDB:8bpg

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion ChromatographyImmunoaffinity Capture	Western blottingFlow cytometryMORPH	5	38731868 40098346 41216884 30451371 31320591

Sequence, Structure & Domains

Sequences

Length

390

Mass

43,146

Sequence

MDFWLWPLYFLPVSGALRILPEVKVEGELGGSVTIKCPLPEMHVRIYLCREMAGSGTCGTVVSTTNFIKAEYKGRVTLKQYPRKNLFLVEVTQLTESDSGVYACGAGMNTDRGKTQKVTLNVHSEYEPSWEEQPMPETPKWFHLPYLFQMPAYASSSKFVTRVTTPAQRGKVPPVHHSSPTTQITHRPRVSRASSVAGDKPRTFLPSTTASKISALEGLLKPQTPSYNHHTRLHRQRALDYGSQSGREGQGFHILIPTILGLFLLALLGLVVKRAVERRKALSRRARRLAVRMRALESSQRPRGSPRPRSQNNIYSACPRRARGADAAGTGEAPVPGPGAPLPPAPLQVSESPWLHAPSLKTSCEYVSLYHQPAAMMEDSDSDDYINVPA

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=O60667-1; Sequence=Displayed; Name=2; IsoId=O60667-2; Sequence=VSP_042947; Name=3; IsoId=O60667-3; Sequence=VSP_045188, VSP_045189

Alternative Sequence

13..124; Missing (in isoform 2); 237..245; RALDYGSQS -> SPLQAGPPT (in isoform 3); 249..390; GQGFHILIPTILGLFLLALLGLVVKRAVERRKALSRRARRLAVRMRALESSQRPRGSPRPRSQNNIYSACPRRARGADAAGTGEAPVPGPGAPLPPAPLQVSESPWLHAPSLKTSCEYVSLYHQPAAMMEDSDSDDYINVPA -> DARPGELPEAPRVAATALPKQHLQRLPAARSWSGRCRHRGGPRSRPRSAVAPRPAAGV (in isoform 3)

3D Structural Models

Turn

53..55; 64..66

Helix

70..72; 82..84; 96..98

Beta Strand

22..28; 33..38; 46..51; 57..63; 75..81; 86..91; 100..108; 110..123

3D Structure

Electron microscopy (6); X-ray crystallography (1)

Domain & Motif Annotations

Compositional Bias

293..311; Low complexity; 325..334; Low complexity; 335..346; Pro residues

Domain (CC)

The Ig-like V-set domain comprises three loops analogous to the complementarity-determining regions (CDR) of Ig variable domains, which are responsible for engaging IgM. Mediates multivalent interactions with the CH4 domains of pentameric IgM, facilitating receptor clustering and signaling.

Domain (FT)

23..123; Ig-like

Region

33..115; CDR4; 40..45; CDR1; 59..70; CDR2; 106..115; CDR3; 166..204; Disordered; 293..348; Disordered

Clinical Relevance

Antibody

HPA003910