Protein detail

CTND1

Catenin delta-1 (Cadherin-associated Src substrate) (CAS) (p120 catenin) (p120(ctn)) (p120(cas))

Entry name CTND1	UniProt ID O60716	EVMP score 0.38
Frequency 2	Transmembrane count	Protein classification Cancer-related genesDisease related genesHuman disease related genesPlasma proteinsPotential drug targetsPredicted intracellular proteinsTransporters

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Catenin delta-1 (Cadherin-associated Src substrate) (CAS) (p120 catenin) (p120(ctn)) (p120(cas))

Protein Class

Cancer-related genesDisease related genesHuman disease related genesPlasma proteinsPotential drug targetsPredicted intracellular proteinsTransporters

Protein Function

Cancer-related genes:Mutational cancer driver genes
Predicted intracellular proteins
Potential drug targets
Human disease related genes:Congenital malformations:Congenital malformations of skin
Transporters:Accessory Factors Involved in Transport
Disease related genes

Ensembl

ENSG00000198561

Entrez Gene Symbol

CTNND1

Gene Synonym

CTNNDKIAA0384p120p120casp120ctn

Gene Description

Catenin delta 1

Chromosome

Position

57753243-57819546

Frequency

EVMP Score

0.38

Fluorescence & Localization

Tissue Specificlymphoid tissueCell SpecificcDCSingle-Nuclei Brain SpecificleukocyteBlood Cell SpecificT-regBlood Lineage SpecificT-cells

Function & Pathway

Protein Function

Cancer-related genes:Mutational cancer driver genes
Predicted intracellular proteins
Potential drug targets
Human disease related genes:Congenital malformations:Congenital malformations of skin
Transporters:Accessory Factors Involved in Transport
Disease related genes

Cellular Component

Molecular Function

Biological Process

KEGG

Reactome

Canonical Pathways

M8626 Sig bcr signaling pathway
M10 Pid bcr 5pathway

Mediation Categories

Clinical-translation mediationFusion and delivery mediationReceptor-signaling mediation

Relations & Evidence

Enzyme-Mediated Modification

48 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
CTNND1	PAK5	Q9P286	S	288	phosphorylation	dbPTMSparser_ProtMapperProtMapper	dbPTM:18669648 ProtMapper:28007610 dbPTM:18220336 dbPTM:20564219
CTNND1	FYN	P06241	Y	112	phosphorylation	NCI-PID_ProtMapperdbPTMREACH_ProtMapperProtMapper	ProtMapper:26477567 ProtMapper:17194753 dbPTM:17194753
CTNND1	FYN	P06241	Y	96	phosphorylation	NCI-PID_ProtMapperProtMapper	ProtMapper:17194753
CTNND1	FYN	P06241	Y	228	phosphorylation	NCI-PID_ProtMapperProtMapper	ProtMapper:17194753
CTNND1	FYN	P06241	Y	217	phosphorylation	NCI-PID_ProtMapperProtMapper	ProtMapper:17194753
CTNND1	SRC	P12931	Y	296	phosphorylation	PhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperHPRDKEASIGNOR_ProtMapper	SIGNOR:11382764 HPRD:20068231 KEA:11382764 HPRD:11382764 ProtMapper:11382764 HPRD:17016520
CTNND1	SRC	P12931	Y	257	phosphorylation	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperHPRDKEASIGNOR_ProtMapper	HPRD:18707149 SIGNOR:11382764 KEA:11382764 HPRD:11382764 ProtMapper:11382764 HPRD:17389395 HPRD:17016520
CTNND1	SRC	P12931	Y	228	phosphorylation	Sparser_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperHPRDRLIMS-P_ProtMapperKEASIGNOR_ProtMapperREACH_ProtMapper	ProtMapper:26477567 SIGNOR:11382764 HPRD:14996911 HPRD:20068231 KEA:11382764 ProtMapper:19138410 ProtMapper:17194753 ProtMapper:23457577 ProtMapper:11382764 HPRD:17389395 HPRD:17016520
CTNND1	SRC	P12931	Y	96	phosphorylation	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperHPRDKEASIGNOR_ProtMapper	SIGNOR:11382764 KEA:11382764 HPRD:11382764 ProtMapper:11382764 HPRD:17016520
CTNND1	SRC	P12931	Y	291	phosphorylation	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperHPRDKEASIGNOR_ProtMapper	SIGNOR:11382764 HPRD:20068231 KEA:11382764 HPRD:18669648 HPRD:11382764 ProtMapper:11382764 HPRD:17016520

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Ligand-Receptor Signaling

11 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
plasma_membrane	plasma_membrane	OmniPath	No	No	No	No	No

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Regulatory Interaction Network

19 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
KC1A	P48729	CTND1	O60716	Yes	Yes	No	Sparser_ProtMapperPhosphoSite_norefSIGNORProtMapperPhosphoSite	SIGNOR:24412065 PhosphoSite:21670201 ProtMapper:24412065 ProtMapper:31557964
MK01	P28482	CTND1	O60716	Yes	No	Yes	SIGNORPhosphoSite_ProtMapperProtMapper	SIGNOR:32010791
CTND1	O60716	CADH5	P33151	Yes	Yes	No	SIGNORProtMapperHPRDRLIMS-P_ProtMapperBioGRIDWang	BioGRID:11855855 BioGRID:9378757 HPRD:11855855 SIGNOR:14610055 ProtMapper:24590762 HPRD:9378757
KPCA	P17252	CTND1	O60716	Yes	No	Yes	Sparser_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetSIGNORProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper	ProtMapper:26477567 PhosphoSite:22798526 PhosphoSite:31953100 PhosphoSite:18950621 ProtMapper:22798526 SIGNOR:22798526
KAPCA	P17612	CTND1	O60716	Yes	No	Yes	SIGNOR_ProtMapperiPTMnetSIGNORProtMapper	SIGNOR:22798526 ProtMapper:22798526
EGFR	P00533	CTND1	O60716	Yes	No	Yes	HPRD_MIMPSIGNORProtMapperHINTPhosphoSite_KEALit-BM-17HPRDIntActWangBEL-Large-Corpus_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPiPTMnetPhosphoPointKEAHPRD_KEASIGNOR_ProtMapperREACH_ProtMapperSparser_ProtMapperACSNSPIKE_LCHPRD-phos	ProtMapper:20974127 SPIKE_LC:17145710 Lit-BM-17:9535896 HINT:9535896 ProtMapper:15951569 ProtMapper:14996911 ACSN:22558232 ProtMapper:18950621 ACSN:17496910 ProtMapper:26067913 HPRD-phos:14996911 HINT:25402006 IntAct:24658140 ProtMapper:17016520 Lit-BM-17:15657067 HPRD-phos:20068231 Lit-BM-17:24189400 Lit-BM-17:27316454 ACSN:14585353 ACSN:12040186 SIGNOR:14996911 ProtMapper:17389395 Lit-BM-17:24658140 HINT:24658140 HPRD-phos:17389395 IntAct:31980649 KEA:14996911 HPRD:14996911 ACSN:19568798 Lit-BM-17:24797263 ProtMapper:23481205 ProtMapper:20068231 Lit-BM-17:25402006 HINT:15657067 HPRD-phos:17016520
CTND1	O60716	CADH2	P19022	Yes	Yes	No	SIGNORHINTBioGRIDInnateDBWang	InnateDB:8660921 BioGRID:24562000 SIGNOR:14610055 HINT:21357690 HINT:8660921 HINT:33961781
MK03	P27361	CTND1	O60716	Yes	No	Yes	PhosphoSite_norefSIGNORProtMapperPhosphoSitePhosphoSite_ProtMapper	PhosphoSite:30808747 PhosphoSite:26302406 PhosphoSite:32010791 SIGNOR:32010791
CTND1	O60716	RAC1	P63000	Yes	Yes	No	WangSIGNOR	SIGNOR:22946057

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Protein Complex Composition

2 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
CTNND1-GLIS2 complex	CTNND1 GLIS2	O60716 Q9BZE0	0:0	CORUM	CORUM:6599	17344476
	CTNND1 LONP1	O60716 P36776	0:0	hu.MAP2

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationDensity Gradient CentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion Chromatography	Mass spectrometry	12	37786918 32284825 33035814 35611462 29436780 37786918 37702715 34817906 28986585 30646616 33709510 38321535

Sequence, Structure & Domains

Sequences

Length

968

Mass

108,170

Sequence

MDDSEVESTASILASVKEQEAQFEKLTRALEEERRHVSAQLERVRVSPQDANPLMANGTLTRRHQNGRFVGDADLERQKFSDLKLNGPQDHSHLLYSTIPRMQEPGQIVETYTEEDPEGAMSVVSVETSDDGTTRRTETTVKKVVKTVTTRTVQPVAMGPDGLPVDASSVSNNYIQTLGRDFRKNGNGGPGPYVGQAGTATLPRNFHYPPDGYSRHYEDGYPGGSDNYGSLSRVTRIEERYRPSMEGYRAPSRQDVYGPQPQVRVGGSSVDLHRFHPEPYGLEDDQRSMGYDDLDYGMMSDYGTARRTGTPSDPRRRLRSYEDMIGEEVPSDQYYWAPLAQHERGSLASLDSLRKGGPPPPNWRQPELPEVIAMLGFRLDAVKSNAAAYLQHLCYRNDKVKTDVRKLKGIPVLVGLLDHPKKEVHLGACGALKNISFGRDQDNKIAIKNCDGVPALVRLLRKARDMDLTEVITGTLWNLSSHDSIKMEIVDHALHALTDEVIIPHSGWEREPNEDCKPRHIEWESVLTNTAGCLRNVSSERSEARRKLRECDGLVDALIFIVQAEIGQKDSDSKLVENCVCLLRNLSYQVHREIPQAERYQEAAPNVANNTGPHAASCFGAKKGKDEWFSRGKKPIEDPANDTVDFPKRTSPARGYELLFQPEVVRIYISLLKESKTPAILEASAGAIQNLCAGRWTYGRYIRSALRQEKALSAIADLLTNEHERVVKAASGALRNLAVDARNKELIGKHAIPNLVKNLPGGQQNSSWNFSEDTVISILNTINEVIAENLEAAKKLRETQGIEKLVLINKSGNRSEKEVRAAALVLQTIWGYKELRKPLEKEGWKKSDFQVNLNNASRSQSSHSYDDSTLPLIDRNQKSDKKPDREEIQMSNMGSNTKSLDNNYSTPNERGDHNRTLDRSGDLGDMEPLKGTTPLMQDEGQESLEEELDVLVLDDEGGQVSYPSMQKI

Alternative Products

Event=Alternative splicing, Alternative initiation; Named isoforms=32; Comment=Isoforms result of a combination of four transcription start sites and three alternatively spliced exons(A, B and C).; Name=1ABC; IsoId=O60716-1; Sequence=Displayed; Name=1AB; Synonyms=p120-1AB; IsoId=O60716-2; Sequence=VSP_006743; Name=1AC; IsoId=O60716-3; Sequence=VSP_006745; Name=1BC; Synonyms=p120-1A; IsoId=O60716-4; Sequence=VSP_006744; Name=1A; IsoId=O60716-5; Sequence=VSP_006743, VSP_006745; Name=1B; IsoId=O60716-6; Sequence=VSP_006743, VSP_006744; Name=1C; IsoId=O60716-7; Sequence=VSP_006744, VSP_006745; Name=1; IsoId=O60716-8; Sequence=VSP_006743, VSP_006744, VSP_006745; Name=2ABC; IsoId=O60716-9; Sequence=VSP_006740; Name=2AB; IsoId=O60716-10; Sequence=VSP_006740, VSP_006743; Name=2AC; IsoId=O60716-11; Sequence=VSP_006740, VSP_006745; Name=2BC; IsoId=O60716-12; Sequence=VSP_006740, VSP_006744; Name=2A; IsoId=O60716-13; Sequence=VSP_006740, VSP_006743, VSP_006745; Name=2B; IsoId=O60716-14; Sequence=VSP_006740, VSP_006743, VSP_006744; Name=2C; IsoId=O60716-15; Sequence=VSP_006740, VSP_006744, VSP_006745; Name=2; IsoId=O60716-16; Sequence=VSP_006740, VSP_006743, VSP_006744, VSP_006745; Name=3ABC; IsoId=O60716-17; Sequence=VSP_006741; Name=3AB; IsoId=O60716-18; Sequence=VSP_006741, VSP_006743; Name=3AC; IsoId=O60716-19; Sequence=VSP_006741, VSP_006745; Name=3BC; IsoId=O60716-20; Sequence=VSP_006741, VSP_006744; Name=3A; IsoId=O60716-21; Sequence=VSP_006741, VSP_006743, VSP_006745; Name=3B; IsoId=O60716-22; Sequence=VSP_006741, VSP_006743, VSP_006744; Name=3C; IsoId=O60716-23; Sequence=VSP_006741, VSP_006744, VSP_006745; Name=3; IsoId=O60716-24; Sequence=VSP_006741, VSP_006743, VSP_006744, VSP_006745; Name=4ABC; IsoId=O60716-25; Sequence=VSP_006742; Name=4AB; IsoId=O60716-26; Sequence=VSP_006742, VSP_006743; Name=4AC; IsoId=O60716-27; Sequence=VSP_006742, VSP_006745; Name=4BC; IsoId=O60716-28; Sequence=VSP_006742, VSP_006744; Name=4A; IsoId=O60716-29; Sequence=VSP_006742, VSP_006743, VSP_006745; Name=4B; IsoId=O60716-30; Sequence=VSP_006742, VSP_006743, VSP_006744; Name=4C; IsoId=O60716-31; Sequence=VSP_006742, VSP_006744, VSP_006745; Name=4; IsoId=O60716-32; Sequence=VSP_006742, VSP_006743, VSP_006744, VSP_006745

Alternative Sequence

1..323; Missing (in isoform 4ABC, isoform 4AB, isoform 4AC, isoform 4BC, isoform 4A, isoform 4B, isoform 4C and isoform 4); 1..101; Missing (in isoform 3ABC, isoform 3AB, isoform 3AC, isoform 3BC, isoform 3A, isoform 3B, isoform 3C and isoform 3); 1..54; Missing (in isoform 2ABC, isoform 2AB, isoform 2AC, isoform 2BC, isoform 2A, isoform 2B, isoform 2C and isoform 2); 626..631; Missing (in isoform 1AB, isoform 1A, isoform 1B, isoform 1, isoform 2AB, isoform 2A, isoform 2B, isoform 2, isoform 3AB, isoform 3A, isoform 3B, isoform 3, isoform 4AB, isoform 4A, isoform 4B and isoform 4); 880..900; Missing (in isoform 1BC, isoform 1B, isoform 1C, isoform 1, isoform 2BC, isoform 2B, isoform 2C, isoform 2, isoform 3BC, isoform 3B, isoform 3C, isoform 3, isoform 4BC, isoform 4B, isoform 4C and isoform 4); 937..965; Missing (in isoform 1AC, isoform 1A, isoform 1C, isoform 1, isoform 2AC, isoform 2A, isoform 2C, isoform 2, isoform 3AC, isoform 3A, isoform 3C, isoform 3, isoform 4AC, isoform 4A, isoform 4C and isoform 4)

3D Structural Models

Turn

841..843

Helix

368..374; 380..394; 398..406; 409..415; 416..418; 422..435; 441..449; 452..462; 466..479; 483..485; 486..492; 494..500; 502..506; 524..537; 542..550; 554..567; 574..587; 590..593; 655..660; 662..674; 678..692; 697..706; 709..717; 718..720; 724..738; 744..757; 766..768; 772..786; 790..798; 801..809; 816..830; 833..840; 846..849

Beta Strand

437..439; 759..763; 812..814

3D Structure

X-ray crystallography (2)

Domain & Motif Annotations

Compositional Bias

875..888; Basic and acidic residues; 889..908; Polar residues; 909..922; Basic and acidic residues

Repeat

358..395; ARM 1; 398..437; ARM 2; 441..475; ARM 3; 476..516; ARM 4; 534..573; ARM 5; 583..624; ARM 6; 653..693; ARM 7; 700..739; ARM 8; 740..780; ARM 9; 781..826; ARM 10

Motif

O60716-2:622..629; Nuclear localization signal (NLS); O60716-5:622..629; Nuclear localization signal (NLS); O60716-6:622..629; Nuclear localization signal (NLS); O60716-8:622..629; Nuclear localization signal (NLS); O60716-10:568..575; Nuclear localization signal (NLS); O60716-13:622..629; Nuclear localization signal (NLS); O60716-14:622..629; Nuclear localization signal (NLS); O60716-16:622..629; Nuclear localization signal (NLS); O60716-18:521..528; Nuclear localization signal (NLS); O60716-21:521..528; Nuclear localization signal (NLS); O60716-22:521..528; Nuclear localization signal (NLS); O60716-24:521..528; Nuclear localization signal (NLS); O60716-26:299..306; Nuclear localization signal (NLS); O60716-29:299..306; Nuclear localization signal (NLS); O60716-30:299..306; Nuclear localization signal (NLS); O60716-32:299..306; Nuclear localization signal (NLS)

Coiled Coil

10..46

Domain (CC)

A possible nuclear localization signal exists in all isoforms where Asp-626--631-Arg are deleted.; DOMAIN: ARM repeats 1 to 5 mediate interaction with cadherins.

Region

1..357; Necessary and sufficient for interaction with CCDC85B; 855..944; Disordered

Protein Families

Beta-catenin family

Sequence Similarities

Belongs to the beta-catenin family.

Clinical Relevance

Disease Involvement

Cancer-related genesDisease variantEctodermal dysplasia

Drugs

PEXMETINIB TALMAPIMOD SB203580 PH-797804 TAK-715 COMPOUND 4E [PMID: 35546685]RALIMETINIB DORAMAPIMOD PAMAPIMOD VX-702 NEFLAMAPIMOD

Antibody

CAB003837 HPA015954 HPA015955

Interaction Protein

ENSG00000039068ENSG00000146648ENSG00000149177ENSG00000162407ENSG00000168036ENSG00000170558ENSG00000177485

Interaction Count

Interaction Dataset

intact_biogridbiogrid_opencell